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Pre-filled syringe filling syringe having resin barrel with aqueous solution containing hyaluronic acid or salt thereof

A pre-filled syringe and hyaluronic acid technology, applied in the directions of syringes, ampoule syringes, hypodermic injection devices, etc., can solve the problems of high cost, easy breakage of glass barrels, and inability to burn together.

Inactive Publication Date: 2014-01-29
DENKA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, the glass cylinder is relatively easy to break, and it needs to be separated from other parts when it is discarded. It cannot be burned and disposed of together, and the cost is also high. Therefore, it is desirable to use a resin cylinder.

Method used

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  • Pre-filled syringe filling syringe having resin barrel with aqueous solution containing hyaluronic acid or salt thereof
  • Pre-filled syringe filling syringe having resin barrel with aqueous solution containing hyaluronic acid or salt thereof
  • Pre-filled syringe filling syringe having resin barrel with aqueous solution containing hyaluronic acid or salt thereof

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Experimental program
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Effect test

Embodiment 1

[0060] The sodium hyaluronate aqueous solution was adjusted in the following order. First, after heat-sterilizing 1 liter of a medium consisting of 5% glucose, 0.2% potassium primary phosphate, 1.0% polypeptone, and 0.5% yeast extract, Streptococcus equi ( Streptococcus equi) FM-100 (Wei Gong Yan Tiao No. 9027) for inoculation. While blowing air at 1vvm, stir at 200 rpm, and cultivate for 20 hours at a temperature of 33°C and a pH of 8.5 (controlled by automatic dropwise addition of 20% sodium hydroxide). After this solution was filtered with a bacterial filter, it was dialyzed against water for 12 hours to recover the hyaluronic acid solution in the dialysis membrane. In order to prevent the incorporation of iron, the collection container uses a container made of glass on the inner surface. Sodium chloride was added thereto so as to be 2.5%, and ethanol was added in an amount twice that of the hyaluronic acid solution to precipitate sodium hyaluronate. Wash the precipitate...

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Abstract

Provided is a pre-filled syringe that can stably store a highly-pure sodium hyaluronate aqueous solution that fills the inside of a resin barrel. Provided is a pre-filled syringe that fills a syringe having a resin barrel with an aqueous solution containing hyaluronic acid or a salt thereof. Moreover, the aqueous solution containing hyaluronic acid or a salt thereof contains a divalent soluble iron content of no greater than 5 ppb, and contains at least one additive selected from the group consisting of a metal thiosulfate, a metal thiocyanate, a thiourea, a thiosemicarbazide, a thioketone, and a sulfide.

Description

technical field [0001] The present invention relates to a prefilled syringe in which an aqueous solution containing hyaluronic acid or hyaluronate is injected into a syringe having a resin barrel. Background technique [0002] It is known that hyaluronic acid refers to a polysaccharide formed by combining N-acetylglucosamine and glucuronic acid disaccharide units. Hyaluronic acid is generally used as a raw material for pharmaceuticals, cosmetics, foods, and the like. As a method for producing hyaluronic acid, there is a method of producing hyaluronic acid using extracts derived from chicken combs, etc., or a method of producing hyaluronic acid using a fermentation method using microorganisms. [0003] For example, Patent Document 1 describes production of hyaluronic acid by a fermentation method using Streptococcus zooepidemicus. In addition, Patent Document 2 describes that hyaluronic acid powder is produced by a fermentation method using Streptococcus equi (ATCC9527). ...

Claims

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Application Information

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IPC IPC(8): A61K31/728A61K9/08A61K47/16A61K47/20A61M5/28A61P19/02
CPCA61K9/0019A61M5/3129A61K31/728A61K47/20A61P19/02A61K9/08A61M5/24
Inventor 能见健司岛田贤太郎守川忠志
Owner DENKA CO LTD
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