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Method for preparing enteromorpha extract solution for inhibiting prorocentrum micans and phaeodactylum tricornutum bohlin

A technology of Proto dinoflagellate and Phaeodactylum sp., which is applied in the field of medicine, can solve the problems of large amount of impurities in products, long extraction process, unclean removal, etc., and achieves the effects of high purity, high content of active ingredients and no waste water discharge.

Inactive Publication Date: 2014-02-05
WEIHAI JINLIN AQUATIC PROD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of the current domestic extraction processes use 85% acetic acid percolation method to extract belladonna extract. However, the disadvantages of the current process are that the extraction process is long, the chlorophyll is much, and the removal is not clean, and the product has a large amount of impurities

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] 1. Take 100kg of belladonna raw material and crush it into 10--20 mesh;

[0019] 2. Add 0.5% hydrochloric acid solution to the pulverized belladonna raw material and stir twice, each time for 3 hours. Add hydrochloric acid aqueous solution for the first time to be 10 times of raw material weight, add hydrochloric acid aqueous solution for the second time to be 6 times of raw material weight, combine and stir liquid, filter;

[0020] 3. Adsorb and separate the filtrate through D101 resin in the pores, the adsorption flow rate is 3BV / H, and then wash with 6BV of water until PH=6--7;

[0021] 4. Elute with 4BV75% ethanol solution, the elution flow rate is 3BV / H, collect the eluate

[0022] 5. Concentrate the eluent to an alcohol content of about 30%, to obtain 13.6kg of belladonna extract with a content of 1.61%, and the yield is 89.4% based on the raw material content.

Embodiment 2

[0024] 1. Take 100kg of belladonna raw material and crush it into 10--20 mesh;

[0025] 2. Add 0.1% sulfuric acid solution to the pulverized belladonna raw material and stir twice, each time for 3 hours. Add sulfuric acid aqueous solution for the first time to be 12 times of raw material weight, add sulfuric acid aqueous solution for the second time to be 8 times of raw material weight, combine and stir liquid, filter;

[0026] 3. Adsorb and separate the filtrate through D101 resin in the pores, the adsorption flow rate is 3BV / H, and then wash with 6BV of water until PH=6--7;

[0027] 4. Elute with 4BV80% ethanol solution, the elution flow rate is 3BV / H, and collect the eluate;

[0028] 5. Concentrate the eluent to an alcohol content of about 30%, to obtain 14.9kg of belladonna extract with a content of 1.53%, and the yield is 93.1% based on the raw material content.

[0029] The BV mentioned in the present invention is the unit of double column volume.

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Abstract

The invention discloses a method for preparing an enteromorpha extract solution for inhibiting prorocentrum micans and phaeodactylum tricornutum bohlin, belongs to the technical field of medicines, in particular relates to a method for preparing an atropa belladonna extract and provides a method for preparing the atropa belladonna extract, wherein the method is short in process flow, high in product purity, sewage-free, environment-friendly and pollution-free. The preparation method comprises the following steps: by taking herba belladonnae as a raw material, crushing the raw material, adding a sulfuric acid or hydrochloric acid solution for stirring, filtering the stirred solution, adsorbing and separating the filtered solution by using resin, eluting by using an ethanol solution, and concentrating the eluate to obtain the atropa belladonna extract. Because a normal-temperature acid solution extraction method is adopted, the dissolution of chlorophyll and impurities is small, and the atropa belladonna alkaloid is easily extracted from the acid solution, so that the active ingredient content in the extracted solution is high, and fewer impurities are contained in the extracted solution.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a preparation method of an enteromorpha extract that inhibits marine Prorocentrum and Phaeodactylum tricornutum. Background technique [0002] Belladonna is a herb of the Solanaceae family. The active ingredient is hyoscyamine, which has the same effect as atropine. It is mainly used for stomach cramps, stomach and duodenal ulcers, abdominal pain caused by biliary colic, ureteral stones, gastritis and stomach cramps. cause vomiting and diarrhea. Most of the current domestic extraction processes use 85% acetic acid percolation method to extract belladonna extract. However, the disadvantages of the current process are that the extraction process is long, the chlorophyll is much, and the removal is not clean, and the product has a large amount of impurities. Contents of the invention [0003] The technical problem to be solved by the present invention is to provide a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/81A61P1/04A61P1/06A61P1/16A61P13/04A01N65/03A01P13/02
Inventor 李柏省
Owner WEIHAI JINLIN AQUATIC PROD
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