Preparation method of konjac glucomannan fiber scaffold material

A technology of konjac glucomannan and fiber scaffold, which is applied in the field of biomedical materials, can solve the problems of insufficient mechanical properties and poor degradation of KGM, and achieve the effects of good gelation, good cartilage defects, and controllable degradation rate

Active Publication Date: 2014-02-05
KUNMING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, acetic acid, nitric acid, benzoic acid, xanthan gum, methyl ester, gallic acid, staghorn alginate, starch, soybean protein isolate, etc. are used as modifiers to modify KGM, but the modified KGM has Poor degradability, insufficient mechanical properties and other shortcomings, and the use of strong acid sulfuric acid as a modifier to modify KGM and prepare fiber scaffold materials has not yet been found

Method used

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  • Preparation method of konjac glucomannan fiber scaffold material
  • Preparation method of konjac glucomannan fiber scaffold material
  • Preparation method of konjac glucomannan fiber scaffold material

Examples

Experimental program
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Effect test

Embodiment 1

[0028] Such as figure 1 As shown, the preparation method of the konjac glucomannan fiber scaffold material described in this embodiment specifically includes the following steps:

[0029] (1) Dilute concentrated sulfuric acid with distilled water, then add glycerin, and stir evenly to obtain a mixed solution A, wherein the volume ratio of concentrated sulfuric acid to water is 1:200, and the volume ratio of glycerol to water is 1:100;

[0030] (2) Add konjac glucomannan to the mixed solution A, and stir to dissolve it completely to obtain the mixed glue B. The mass ratio of konjac glucomannan to the water added in step (1) is 1:70;

[0031] (3) Microwave the mixed glue B for 10 minutes, stir it at room temperature to cool it, filter it through 400 mesh, and then place it under a negative pressure of 500 mmHg for defoaming to obtain a modified composite glue C, which is sealed for later use ;

[0032] (4) Add glycerol to absolute ethanol, and stir evenly to obtain a mixture D...

Embodiment 2

[0037] Such as figure 1 As shown, the preparation method of the konjac glucomannan fiber scaffold material described in this embodiment specifically includes the following steps:

[0038] (1) Dilute concentrated sulfuric acid with distilled water, then add glycerin, and stir evenly to obtain a mixed solution A, wherein the volume ratio of concentrated sulfuric acid to water is 1:1000, and the volume ratio of glycerol to water is 1:500;

[0039] (2) Add konjac glucomannan to mixed solution A, and stir to completely dissolve to obtain mixed glue B. The mass ratio of konjac glucomannan to water added in step (1) is 1:90;

[0040] (3) Microwave the mixed glue B for 5 minutes, stir it at room temperature to cool it, filter it through 400 mesh, and then place it under a negative pressure of 450 mm Hg to degas to obtain the modified composite glue C, seal it for later use ;

[0041] (4) Add glycerol to absolute ethanol, and stir evenly to obtain a mixture D, wherein the volume ratio ...

Embodiment 3

[0046] Such as figure 1 As shown, the preparation method of the konjac glucomannan fiber scaffold material described in this embodiment specifically includes the following steps:

[0047] (1) Dilute concentrated sulfuric acid with distilled water, then add glycerin, and stir evenly to obtain a mixed solution A, wherein the volume ratio of concentrated sulfuric acid to water is 1:2000, and the volume ratio of glycerol to water is 1:1000;

[0048] (2) Add konjac glucomannan to the mixed solution A, and stir to dissolve it completely to obtain the mixed glue B. The mass ratio of konjac glucomannan to the water added in step (1) is 1:120;

[0049] (3) Microwave the mixed glue B for 1 min, stir it at room temperature to cool it, filter it through 200 mesh, and then place it under a negative pressure of 400 mmHg for defoaming to obtain a modified composite glue C, seal it for later use ;

[0050] (4) Add glycerol to absolute ethanol, and stir evenly to obtain a mixture D, wherein ...

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Abstract

The invention discloses a preparation method of a konjac glucomannan fiber scaffold material, belonging to the field of biomedical materials. The main component of the konjac glucomannan fiber scaffold material is konjac glucomannan, wherein the mass ratio of konjac glucomannan to water is (1:120)-(1:70), the volume ratio of sulfuric acid to water is (1:2,000)-(1:200), the mass percentage of calcium hydroxide in a calcium hydroxide solution is 0.05-2%, and the volume percentage ratio of a calcium hydroxide aqueous solution to absolute ethyl alcohol in crosslinking liquid is (1:2)-(1:0.5). According to the preparation method disclosed by the invention, through sulfuric acid modification and calcium hydroxide aqueous solution crosslinking, calcium sulfate can be generated while chondroitin sulfate is released so that the scaffold material can be better applied to articular cartilage repair.

Description

technical field [0001] The invention relates to a preparation method of a konjac glucomannan fiber scaffold material, which can be applied to articular cartilage repair and belongs to the field of biomedical materials. Background technique [0002] High-energy violent trauma, intra-articular infection, and other diseases can cause severe bone defects, as well as damage to articular cartilage. Once the articular cartilage is damaged or damaged, it can lead to swelling, effusion, pain, and locking of the affected joints. patient joint function. In addition, the self-healing ability of cartilage tissue is very limited. Once damaged, permanent lesions will remain, and treatment is also quite difficult, mainly because: there are no blood vessels in cartilage tissue, and chondrocytes lack the ability to migrate and cannot quickly gather to the trauma site; The content of fibers in articular cartilage is low, only a small amount of collagen fibers, and the main chemical compositio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J7/12C08J3/28C08L5/00A61L27/20
Inventor 陈庆华朱维波颜廷亭
Owner KUNMING UNIV OF SCI & TECH
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