Use of garlicin in preparation of hyperlipoidemia treatment medicines

A technology for hyperlipidemia and medicine is applied in the application field of allicin in the preparation of medicine for treating hyperlipidemia, and achieves the effects of smooth stool, clear medicine source and obvious therapeutic effect.

Inactive Publication Date: 2014-03-12
上海方远科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] But so far, there is no report about the use of ente

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1 Preparation of enteric-coated garlic tablets

[0026] The enteric-coated garlic tablet is prepared by using freeze-dried garlic powder (alliin content ≥ 30mg / g) as the main raw material and adding suitable pharmaceutical excipients, using existing pharmaceutical technology, and preparing it into tablets, and then coating it with enteric-coated film;

[0027] The tablet weight of described enteric-coated garlic tablet is 500mg, and composition weight percent is:

[0028] (1) Freeze-dried garlic powder (alliin content ≥ 30mg) 70%,

[0029] (2) Pharmaceutical excipients (including coating materials) 30%;

[0030] After the enteric-coated garlic tablets are made, the results of high-performance liquid chromatography show that the content of alliin is 10mg~11mg / tablet, and the potential allicin is greater than 5mg / tablet.

Embodiment 2

[0031] Embodiment 2 pharmacodynamic research

[0032] Animal models of hyperlipidemia and normal animals (SD rats, half male and half female, body weight 200±20g, provided by the Experimental Animal Center of Fudan University) were selected to evaluate the lipid-lowering effect of enteric-coated garlic tablets according to conventional test methods.

[0033] The results showed that the enteric-coated garlic tablets high, medium and low dose groups could significantly reduce the serum triglyceride level of normal rats, and the serum triglyceride level of the high dose group and the medium dose group decreased more significantly; Dosage group can significantly reduce the serum cholesterol level in normal rats;

[0034] The enteric-coated garlic tablet high, medium and low dose groups can significantly reduce the triglyceride level and low-density lipoprotein level in the serum of hyperlipidemia model rats, and wherein the lowering of the triglyceride level is more obvious; The ...

Embodiment 3

[0035] Example 3 Clinical Research

[0036] The present invention carries out clinical observation on the patients with fatty liver combined with hyperlipidemia.

[0037] Research objects: The observed cases were all outpatients, a total of 120 cases were randomly divided into treatment group and control group, including 80 cases in the treatment group (54 males and 26 females), with an average age of 45.4 years and an average course of disease of 3.5 years; the control group There were 40 cases (29 males and 11 females), with an average age of 44.9 years and an average disease duration of 3.6 years.

[0038] Efficacy Judgment Standards:

[0039] (1) Clinical symptoms and signs improve or disappear;

[0040] (2) Refer to the "Guiding Principles for Clinical Research": TC decrease ≥ 20%, or TG decrease ≥ 40%, or HDL increase ≥ 20%;

[0041] (3) The B-ultrasound examination basically returned to normal, and the characteristics of fatty liver decreased;

[0042] (4) ALT retur...

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PUM

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Abstract

The invention belongs to the field of medicines, and relates to a use of an enteric-coated garlic tablet in the preparation of hyperlipoidemia treatment medicines. The weight of the enteric-coated garlic tablet is 500mg, and the enteric-coated garlic tablet comprises 70wt% of lyophiled garlic powder and 30wt% of a pharmaceutical adjuvant, wherein the content of alliin in the lyophiled garlic powder is not lower than 30mg/g, and the pharmaceutical adjuvant contains a coating material. A high performance liquid chromatography result of the enteric-coated garlic tablet shows that the content of alliin in each tablet of the enteric-coated garlic tablet is 10-11mg, and the content of latent allicin in each tablet of the enteric-coated garlic tablet is greater than 5mg. The enteric-coated garlic tablet has the advantages of clear source, wide source, low price, easy obtaining, convenient administration, almost no pharmacological side effects, high bioavailability, safety and effectiveness; and the enteric-coated garlic tablet can avoid the irritation of high-content allicin to the upper gastrointestinal tract, and the garlic flavor does not escape from the oral cavity.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to the new medicinal use of allicin, in particular to the use of allicin, especially the use of enteric-coated garlic tablets in the preparation of medicines for treating hyperlipidemia. Background technique [0002] The chemical name of allicin is: trithiodipropylene. It is known that the enteric-coated garlic tablets made of allicin have inhibitory and bactericidal effects on various cocci, pertussis bacillus, diphtheria bacillus, Shigella bacillus, typhoid and paratyphoid bacillus, Escherichia coli, Mycobacterium tuberculosis, etc. It has an inhibitory effect, and it also shows an inhibitory and killing effect on amoeba, trichomonas vaginalis, and pinworms. [0003] At present, enteric-coated garlic tablets made of allicin as the main component have become a medically acceptable preparation. Usually, the dosage characteristics of this preparation are: the weight of alliin in each 500 mg ta...

Claims

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Application Information

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IPC IPC(8): A61K31/255A61K9/20A61P3/06
Inventor 石倍康尤谊
Owner 上海方远科技发展有限公司
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