Anti gram-positive bacterium composition of anglerfish skin collagen peptide

A peptide anti-Gram, antibacterial composition technology, applied in the field of antibacterial compositions, can solve the problem of no anglerfish peptides and antibiotics antibacterial and bacteriostatic activity, etc., to avoid or reduce the generation of drug-resistant strains, high biological titer and Nutritional value and the effect of increasing economic added value

Active Publication Date: 2014-03-19
中华人民共和国舟山出入境检验检疫局
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there is no research report on the synergistic antibacterial and antibacterial activities of anglerfish peptides and antibiotics

Method used

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  • Anti gram-positive bacterium composition of anglerfish skin collagen peptide
  • Anti gram-positive bacterium composition of anglerfish skin collagen peptide
  • Anti gram-positive bacterium composition of anglerfish skin collagen peptide

Examples

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Effect test

Embodiment 1

[0032] An anglerfish skin collagen peptide anti-Gram-positive bacteria composition, the anglerfish skin collagen peptide antibacterial composition is composed of a concentration of 100 mg / mL anglerfish skin collagen peptide solution and a concentration of 20 μg / mL cephalosporin Thiofur sodium solution is compounded according to the volume ratio of 3:1 to form a compound solution.

Embodiment 2

[0034] An anglerfish skin collagen peptide anti-Gram-positive bacteria composition, the anglerfish skin collagen peptide antibacterial composition is composed of a concentration of 200 mg / mL anglerfish skin collagen peptide solution and a concentration of 20 μg / mL cephalosporin Thiofur sodium solution is compounded according to the volume ratio of 4:1 to form a compound solution. The molecular weight of anglerfish skin collagen peptide is below 2000D.

[0035]

[0036] The preparation method of anglerfish skin collagen peptide is as follows:

[0037] method 1:

[0038] Take 1000 g of washed anglerfish skin and use scissors to cut it into pieces with a length and width of 2 cm×2 cm (the fish skin can fully contact the solution and ensure that the pieces are not too small to cause loss).

[0039] Add 25 L of 0.45% NaOH solution to the anglerfish skin fragments, soak for 24 h, wash with water until the pH is neutral, then add 35 L of n-butanol solution with a volume percen...

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Abstract

The invention discloses an anti gram-positive bacterium composition of anglerfish skin collagen peptide, and the anti gram-positive bacterium composition is prepared by compounding an anglerfish skin collagen peptide solution with a concentration of 100-200 mg / ml and a ceftiofur sodium solution with a concentration of 20 mug / mL according to a volume ratio of 3- 4:1. By combination use and collaborative effects of anglerfish skin collagen peptide and antibiotic ceftiofur sodium, the anti gram-positive bacterium composition has a better bacteria resistance and bacteriostasis activity on gram-positive bacterium, reduces the antibiotic dose, reduces drug residues, avoids or reduces the production of drug resistant strains, and improves the economic added value of anglerfish skin.

Description

technical field [0001] The invention relates to an antibacterial composition, in particular to an anglerfish skin collagen peptide anti-gram-positive bacteria composition. Background technique [0002] In the process of aquatic product processing, the leftovers account for about 30% to 55% of the raw fish, and the collagen content in the leftovers such as fish heads, fish skins, fish bones and residual fish meat ranges from 20% to 50%. Preliminary research results show that aquatic collagen and peptides have the functions of protecting gastric mucosa, anti-ulcer effect, anti-allergic, lowering blood pressure, lowering cholesterol, anti-aging, promoting wound healing, enhancing bone strength and preventing osteoporosis, preventing arthritis, promoting corneal Various physiological functions such as repairing epithelial wounds and promoting growth of corneal epithelial cells (Xu Haiju, Cai Jian, Chen Jiangping. The basic characteristics of aquatic collagen and its application ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/39A61P31/04C12P21/06A61K31/546
Inventor 万婧周向阳相兴伟江玲丽刘颖邵宏宏周秀锦
Owner 中华人民共和国舟山出入境检验检疫局
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