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Pelletizing method for preparation of Chinese medicinal composition

A composition and technology of traditional Chinese medicine, applied in the field of traditional Chinese medicine pharmacy, can solve the problems of easily destroying the screen of the swing granulator, adding too much wetting agent, and many coarse particles, etc., and achieves low hygroscopicity, short melting time, and granulation technology. stable effect

Active Publication Date: 2014-03-26
SHIJIAZHUANG YILING PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the production of Jinlida Granules, due to the stickiness of the dry cream powder, it is better to add lactose, dextrin and other auxiliary materials and use 60% ethanol as the wetting agent to make soft materials, but the addition of too little wetting agent results in loose granules , after drying with a fluidized bed, there are more fine particles below 60 mesh; too much wetting agent is added, the soft material is too sticky and hard, and it is easy to damage the screen of the oscillating granulator, and there are more coarse particles, which also affects yield

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] The API formula is:

[0047] Ginseng 102g, Polygonatum 136g, Atractylodes Rhizoma 68g, Sophora flavescens 56g, Poria 83g, Ophiopogon japonicus 136g, Polygonum multiflorum 83g, Rehmannia glutinosa 102g, Cornus officinalis 136g, Coptis chinensis 56g, Perlan 56g, Lychee seed 136g, Epimedium 56g, Anemarrhena 68g, Salvia 89g, Pueraria 136g, Digupi 83g.

[0048] Preparation of active ingredients

[0049] a. Weigh the traditional Chinese medicinal materials according to the weight ratio of the raw materials, cleanly select them, and break them into pieces;

[0050] b. Add 5 times of water to extract volatile oil from Peilan and Atractylodes, extract for 3 hours, collect the volatile oil in another device, and filter the aqueous solution for later use;

[0051] c. Cornus officinalis uses 5 times the amount of 50% ethanol as a solvent, and after dipping for 12 hours, carries out percolation, and collects the percolation liquid for subsequent use;

[0052] d. Ginseng, Ophiopog...

Embodiment 2

[0059] The API formula is:

[0060] Ginseng 42g, Polygonatum 200g, Atractylodes Rhizoma 30g, Sophora flavescens 60g, Poria 35g, Ophiopogon japonicus 200g, Polygonum multiflorum 35g, Rehmannia glutinosa 120g, Cornus japonica 50g, Coptis chinensis 60g, Perrin 30g, Lychee seed 150g, Epimedium 30g, Anemarrhena 100g, Salvia 35g, Pueraria 200g, Digupi 30g.

[0061] Preparation of active ingredients

[0062] a. Weigh the traditional Chinese medicinal materials according to the weight ratio of the raw materials, cleanly select them, and break them into pieces;

[0063] b. Add 9 times of water to extract volatile oil from Pei Lan and Atractylodes Rhizoma, extract for 6 hours, collect the volatile oil in another device, and filter the aqueous solution for later use;

[0064] c. Cornus officinalis uses 9 times the amount of 90% ethanol as a solvent, and after immersion for 48 hours, carries out percolation, and collects the percolation liquid for subsequent use;

[0065] d. Ginseng, O...

Embodiment 3

[0072] The API formula is:

[0073] Ginseng 160g, Polygonatum 50g, Atractylodes Rhizoma 100g, Sophora flavescens 20g, Poria 100g, Ophiopogon japonicus 50g, Polygonum multiflorum 100g, Rehmannia glutinosa 50g, Cornus 200g, Coptis chinensis 20g, Perrin 60g, Lychee seed 75g, Epimedium 60g, Anemarrhena 30g, Salvia 120g, Pueraria lobata 50g, Digupi 100g.

[0074] Preparation of active ingredients

[0075] a. Weigh the traditional Chinese medicinal materials according to the weight ratio of the raw materials, cleanly select them, and break them into pieces;

[0076] b. Add 5 times of water to extract volatile oil from Peilan and Atractylodes, extract for 3 hours, collect the volatile oil in another device, and filter the aqueous solution for later use;

[0077] c, Cornus uses 5 times the amount of 70% ethanol as a solvent, and after dipping for 12 hours, percolates, and collects the percolation liquid for subsequent use;

[0078] d. Ginseng, Ophiopogon japonicus, Epimedium, Anema...

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PUM

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Abstract

The invention discloses a pelletizing method for a Chinese medicinal composition preparation. The Chinese medicinal composition consists of ginseng, sealwort, Chinese atractylodes, lightyellow sophora root, indian buead, dwarf lilyturf root, prepared tuber fleeceflower root, rehmannia, dogwood, coptis root and fortune eupatorium herb, and can effectively treat diabetes. According to the method, granules are prepared by pelletizing with a wet process. The granules are proper in colors and sizes, and are non-hygroscopic. The process is stable and reliable.

Description

technical field [0001] The invention relates to a granulation method of a traditional Chinese medicine composition, in particular to a wet granulation method of a traditional Chinese medicinal composition, and belongs to the field of traditional Chinese medicine pharmacy. Background technique [0002] In the production process of preparations, both traditional Chinese medicine preparations and western medicine preparations inevitably involve the granulation process. The preparation process of traditional Chinese medicine granules is usually as follows: material selection, impurity removal, extraction, concentration and drying, and granulation. The powder or extract is mixed with a certain proportion of excipients, and water and ethanol are used as wetting agents to prepare the required number of granules. The granulation process or granulation process is a very important link. In order to improve the quality of the finished granules and ensure clinical efficacy, pharmaceutic...

Claims

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Application Information

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IPC IPC(8): A61K36/8969A61K9/16
Inventor 韩月芝侯素云王岳冯莎苏平菊粘立军范文成刘素领史冬霞马桂云
Owner SHIJIAZHUANG YILING PHARMA