Method for preparing acrylonitrile-based saccharide-containing copolymer by free radical polymerization
An acrylonitrile-based and copolymer technology is applied in the field of preparation of sugar-containing polymers, which can solve the problems of poor hydrophilicity and biocompatibility, low flexibility, low mechanical strength, etc., and achieves wide application fields and mild reaction conditions. , avoid the effect of reaction conditions
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Embodiment 1
[0025] Different initiator contents trigger the synthesis of Poly(AN-co-OVSEG), the specific steps are as follows:
[0026] (1) First use Molecular sieve dehydration of pyridine for 48 hours, then respectively take vinyl sebacate and glucose at a molar ratio of 1:1 and add them to the organic solvent pyridine, place on a shaker at 50°C until the substrate is completely dissolved;
[0027] (2) Add alkaline protease at 10mg / mL, add molecular sieve at 0.2g / mL solvent, seal and start reaction, the reaction conditions are shaker at 30-50°C, 150-220r / min for 4-5d. After the reaction, remove the enzyme by filtering with filter paper, remove the organic solvent from the filtrate through a rotary evaporator, and then extract pure OVSEG with a silica gel column.
[0028] (3) Weigh the mass of OVSEG according to the molar ratio of 1:10, pipette the AN, use azobisisobutyronitrile (AIBN) as the initiator, and the amount of the initiator is 1 / 500- 1 / 800, dimethylformamide (DMF) as a solv...
Embodiment 2
[0030] The synthesis reaction of Poly(AN-co-OVESEG) at different reaction temperatures, the specific steps are as follows:
[0031] (1) First use Molecular sieve dehydration of pyridine for 48 hours, then respectively take vinyl sebacate and glucose at a molar ratio of 2:1 and add them to the organic solvent pyridine, place on a shaker at 50°C until the substrate is completely dissolved;
[0032] (2) Add alkaline protease at 20 mg / mL, add molecular sieve at 0.2 g / mL solvent, seal and start reaction, the reaction conditions are shaker at 30-50 °C, 150-220 r / min for 4-5 days. After the reaction, remove the enzyme by filtering with filter paper, remove the organic solvent from the filtrate through a rotary evaporator, and then extract pure OVSEG with a silica gel column.
[0033] (3) Weigh the mass of OVSEG according to the molar ratio of 1:20, pipette the AN, use azobisisobutyronitrile (AIBN) as the initiator, and the amount of the initiator is 1 / 600 of the total molar weight ...
Embodiment 3
[0035] The synthesis reaction of Poly(AN-co-OVSEG) under different reaction times, the specific steps are as follows:
[0036] (1) First use Molecular sieve dehydration of pyridine for 48 hours, then respectively take vinyl sebacate and glucose at a molar ratio of 4:1 and add them to the organic solvent pyridine, and place on a shaker at 50°C until the substrate is completely dissolved;
[0037] (2) Add alkaline protease at 30 mg / mL, add molecular sieve at 0.2 g / mL solvent, seal and start reaction, the reaction conditions are shaker at 30-50 °C, 150-220 r / min for 4-5 days. After the reaction, remove the enzyme by filtering with filter paper, remove the organic solvent from the filtrate through a rotary evaporator, and then extract pure OVSEG with a silica gel column.
[0038] (3) Weigh the mass of OVSEG according to the molar ratio of 1:30, pipette the AN, use azobisisobutyronitrile (AIBN) as the initiator, and the amount of the initiator is 1 / 800 of the total molar weight o...
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