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Method for preparing ibuprofen cream

A technology for preparing cream and oil phase, which is applied in the directions of non-active ingredient medical preparations, medical preparations containing active ingredients, and ointment delivery, etc., can solve the problems of slow onset of pain relief, slow penetration rate, etc. The effect of good pain effect, fast onset of effect and improved drug absorption rate

Active Publication Date: 2014-04-02
郑州大明药物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to overcome the problems of slow penetration rate and slow analgesic onset of existing ibuprofen cream, and provide a new preparation method of ibuprofen cream

Method used

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Examples

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Effect test

Embodiment 1

[0024] The preparation method of ibuprofen cream of the present invention comprises oil phase preparation, water phase preparation, cream preparation, seasoning and filling, and its detailed preparation process is:

[0025] a, the raw material of ibuprofen cream consists of: ibuprofen 1g, white petrolatum 2g, lanolin 1g, beeswax 0.87g, menthol 0.6g, carboxymethyl-ethyl-β-cyclodextrin 3g, ethyl acetate Ester 1g, ethyl p-hydroxybenzoate 0.03g, lavender oil 0.1g, neroli oil 0.1g and water 10.3g;

[0026] b. Preparation of oil phase: prepare various raw materials according to the raw material composition of ibuprofen cream, first mix white petrolatum, lanolin, beeswax and menthol, and heat to 70°C to fully dissolve, and obtain the oil phase after dissolution;

[0027] c. Water phase preparation: dissolve the prepared raw material carboxymethyl-ethyl-β-cyclodextrin in water to obtain carboxymethyl-ethyl-β-cyclodextrin solution; dissolve ibuprofen in ethyl acetate , to obtain ...

Embodiment 2

[0032] The preparation method of ibuprofen cream of the present invention comprises oil phase preparation, water phase preparation, cream preparation, seasoning and filling, and its detailed preparation process is:

[0033] a, the raw material of ibuprofen cream consists of: ibuprofen 1g, white petrolatum 2g, lanolin 1g, beeswax 0.87g, menthol 0.6g, carboxymethyl-ethyl-β-cyclodextrin 3g, ethyl acetate Ester 1g, ethyl p-hydroxybenzoate 0.03g, lavender oil 0.1g, neroli oil 0.1g and water 10.3g;

[0034] b. Oil phase preparation: Prepare various raw materials according to the raw material composition of ibuprofen cream, first mix white petrolatum, lanolin, beeswax and menthol, and heat to 65° C. to fully dissolve, and obtain an oil phase after dissolution;

[0035] c. Water phase preparation: dissolve the prepared raw material carboxymethyl-ethyl-β-cyclodextrin in water to obtain carboxymethyl-ethyl-β-cyclodextrin solution; dissolve ibuprofen in ethyl acetate In , the ethyl...

Embodiment 3

[0040] The preparation method of ibuprofen cream of the present invention comprises oil phase preparation, water phase preparation, cream preparation, seasoning and filling, and its detailed preparation process is:

[0041] a, the raw material of ibuprofen cream consists of: ibuprofen 1g, white petrolatum 2g, lanolin 1g, beeswax 0.87g, menthol 0.6g, carboxymethyl-ethyl-β-cyclodextrin 3g, ethyl acetate Ester 1g, ethyl p-hydroxybenzoate 0.03g, lavender oil 0.1g, neroli oil 0.1g and water 10.3g;

[0042] b. Preparation of oil phase: prepare various raw materials according to the raw material composition of ibuprofen cream, first mix white petrolatum, lanolin, beeswax and menthol, and heat to 70°C to fully dissolve, and obtain the oil phase after dissolution;

[0043] c. Water phase preparation: dissolve the prepared raw material carboxymethyl-ethyl-β-cyclodextrin in water to obtain carboxymethyl-ethyl-β-cyclodextrin solution; dissolve ibuprofen in ethyl acetate , the ethyl ...

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Abstract

The invention discloses a method for preparing ibuprofen cream. The method comprises the following steps: mixing white vaseline, lanolin, beewax and menthol and dissolving to obtain an oil phase; dissolving carboxymethyl-ethyl-beta-cyclodextrin in water to obtain carboxymethyl-ethyl-beta-cyclodextrin solution, dissolving ibuprofen in ethyl acetate to obtain an ibuprofen ethyl acetate solution; adding the ibuprofen ethyl acetate solution into the carboxymethyl-ethyl-beta-cyclodextrin solution to prepare an ibuprofen cyclodextrin inclusion solution, adding ethyl p-hydroxybenzoate into the ibuprofen cyclodextrin inclusion solution to obtain a water phase; adding the oil phase into the water phase, stirring to prepare the ibuprofen cream, and flavoring and filling. By virtue of the ibuprofen cream prepared by the method, the infiltration speed of the ibuprofen cream can be improved, so that the characteristics of quick acting and good pain relieving effect can be achieved.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a preparation method of non-steroidal analgesic and anti-inflammatory drug ibuprofen cream. Background technique [0002] Ibuprofen is a non-steroidal anti-inflammatory analgesic commonly used in clinical practice, and its analgesic effect is remarkable. Ibuprofen cream is used as a non-steroidal analgesic and anti-inflammatory drug for external use, and its therapeutic effect has been fully affirmed clinically. Ibuprofen cream is used to relieve local soft tissue pain, such as muscle pain, joint pain, low back pain, and pain caused by sprains, strains, and strains. It can also be used for symptomatic treatment of osteoarthritis. The drug is a non-steroidal anti-inflammatory analgesic for external use, which can penetrate into deep diseased tissues through the skin and exert analgesic and anti-inflammatory effects by inhibiting the synthesis of pr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K31/192A61K47/48A61P29/00
Inventor 贾晓璐王翠侠蒲薇薇王娜张亚慧
Owner 郑州大明药物科技有限公司
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