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Method and special mold for constructing multi-channel cavernous nerve conduit by two-time molding

A technology for forming molds and sponge nerves, which can be used in home appliances, other home appliances, applications, etc. It can solve problems such as difficult to accurately control the size of the inner and outer diameters, and wrong guidance, so as to improve the efficiency and accuracy of insertion, and solve the problem of shrinkage Problems, size controllable effects

Active Publication Date: 2014-04-02
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The traditional catheter is a hollow single-channel catheter. Although it has a positive effect on nerve regeneration and functional reconstruction, it still has some obvious shortcomings such as excessive diameter and easy to cause misguidance.
[0005] The polymer solution will expand during the freezing process and often shrink during the freeze-drying process. If the multi-channel sponge nerve conduit is prepared by one-time molding method, it is difficult to accurately control its inner and outer diameters due to the shrinkage of the catheter material.

Method used

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  • Method and special mold for constructing multi-channel cavernous nerve conduit by two-time molding
  • Method and special mold for constructing multi-channel cavernous nerve conduit by two-time molding
  • Method and special mold for constructing multi-channel cavernous nerve conduit by two-time molding

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] (1) Solution preparation and first molding

[0059] ① Dissolve cellulose and soybean protein in sodium hydroxide / urea solution respectively to prepare a polymer solution with a mass concentration of 2-10%;

[0060] ② Assemble the mold (single channel) ( figure 1 ), placed in a room temperature environment, so that there is no temperature difference between parts of the mold;

[0061] ③ Inject the polymer solution into the mold, cool down to -20°C (10h), and freeze the polymer solution in the mold cavity;

[0062] ④ Place the frozen polymer mixture and the mold in ③ quickly in a freeze dryer, and freeze-dry at about -50°C to obtain a single mold with an inner diameter of 1.5-2.0mm, an outer diameter of 2.5-3.0mm, and a length of 40mm. Channeled cavernous nerve conduits.

[0063] (2) Second forming

[0064] ① Dissolve cellulose and soybean protein in sodium hydroxide / urea solution respectively to prepare a polymer solution with a mass concentration of 2-10%;

[0065]...

Embodiment 2

[0069] (1) Preparation and first molding of 7-channel sponge nerve conduit solution

[0070] ① Dissolve 7g of cellulose and 3g of soybean protein in 190g of sodium hydroxide / urea solution (13.3g of sodium hydroxide, 22.8g of urea, and 153.9g of water) to prepare cellulose and soybean protein with concentrations of 3.5% and 3.5% respectively. 1.5% polymer solution;

[0071] ② Assemble the mold (single channel) ( figure 1 ), placed in a room temperature environment, so that there is no temperature difference between parts of the mold;

[0072] ③ Inject the polymer solution into the mold, cool down to -20°C (10h), and freeze the polymer solution in the mold cavity;

[0073] ④ Quickly place the frozen polymer mixture and mold in ③ into a freeze dryer, freeze-dry at about -50°C, and obtain a single-channel sponge nerve conduit with an inner diameter of 2.0 mm, an outer diameter of 3.0 mm, and a length of 40 mm. .

[0074] (2) Second forming

[0075] ① Dissolve 7g of cellulose ...

Embodiment 3

[0082] (1) Solution preparation and first molding

[0083] ① Dissolving chitosan in acetic acid with a mass concentration of 2% is prepared into a chitosan solution with a chitosan mass concentration of 3%;

[0084] ② Assemble the mold (single channel) ( figure 1 ), placed in a room temperature environment, so that there is no temperature difference between parts of the mold;

[0085] ③ Inject the polymer solution into the mold, cool down to -20°C (10h), and freeze the polymer solution in the mold cavity;

[0086] ④ Place the frozen polymer mixture and the mold in ③ quickly in a freeze dryer, and freeze-dry at about -50°C to obtain a single mold with an inner diameter of 1.5-2.0mm, an outer diameter of 2.5-3.0mm, and a length of 40mm. Channeled cavernous nerve conduits.

[0087] (2) Second forming

[0088] ① Dissolving chitosan in acetic acid with a mass concentration of 2% is prepared into a chitosan solution with a mass concentration of 3%;

[0089] ② Put the mold (3 to 2...

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Abstract

The invention discloses a method and a special mold for constructing a multi-channel cavernous nerve conduit by two-time molding. The mold comprises a single-channel molding mold and a multi-channel molding mold, wherein the single-channel molding mold and the multi-channel molding mold have the same main body structure and respectively comprise a mold body and an outer mold; each mold body is provided with a tubular mold cavity; each outer mold is provided with a cavity which is completely matched with the corresponding mold body; fixed holes are formed in the two sides of each outer mold or pore plates are arranged on the two sides of each outer mold (fixed holes are formed in each pore plate); when a single fixed hole or a plurality of fixed holes are formed, to the corresponding molding mold is a single-channel molding mold or a multi-channel molding mold; a material injection hole and an exhaust hole are formed in the two top ends of each outer mold. A biodegradable polymer solution is injected into the assembled single-channel molding mold and the assembled multi-channel molding mold, and the single-channel cavernous nerve conduit is obtained after freeze drying; the single-channel cavernous nerve conduit is inserted into the assembled multi-channel molding mold, the polymer solution is injected into the multi-channel molding mold, and the multi-channel cavernous nerve conduit is obtained after freeze drying. According to the method for constructing the multi-channel cavernous nerve conduit by two-time molding, which is disclosed by the invention, the problem of contraction when the multi-channel cavernous nerve conduit is molded is solved.

Description

[0001] technical field [0002] The invention relates to a cavernous nerve guide, in particular to a method for constructing a multi-channel cavernous nerve guide through double molding and a special mold. Background technique [0003] Peripheral nerve injury is a common clinical disease, about 2.8% of trauma patients injured peripheral nerves. There are 2 million cases of peripheral nerve injury in my country every year, and there are nearly 200,000 and 300,000 cases in the United States and Europe each year, respectively. The most common method for repairing peripheral nerve defects clinically is autologous nerve transplantation. However, the source of autologous nerves is limited, often accompanied by functional impairment of the donor site, and is also limited by problems such as repairable length and scars; allogeneic nerve transplantation also has strong immune rejection. With the rapid development of materials science, tissue engineering and regenerative medicine, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B29C33/00B29L23/00
Inventor 陈云赵雷甘丽童攒李银萍
Owner WUHAN UNIV
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