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Preparation method for magnetic nanoparticles with surface aldehyde group functionalization

A magnetic nanoparticle and functionalized technology, applied in the field of nanomaterials, can solve the problems of easy destruction of magnetic nanoparticle structure, low chemical stability, easy oxidation, etc., and achieve rapid separation and enrichment, simple preparation method, specific surface area. big effect

Active Publication Date: 2014-04-09
XI AN JIAOTONG UNIV
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  • Abstract
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Problems solved by technology

However, there are the following problems in the practical application of magnetic nanoparticles: (1) There is a strong magnetic dipole attraction between the magnetic nanoparticles, which makes it easy to agglomerate to form larger aggregates
(2) Magnetic nanoparticles contain Fe 2+ , low chemical stability, easily oxidized
(3) Under acidic conditions, the structure of magnetic nanoparticles is easily destroyed

Method used

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  • Preparation method for magnetic nanoparticles with surface aldehyde group functionalization
  • Preparation method for magnetic nanoparticles with surface aldehyde group functionalization
  • Preparation method for magnetic nanoparticles with surface aldehyde group functionalization

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preparation example Construction

[0026] A preparation method of surface aldehyde functionalized magnetic nanoparticles, comprising the following steps:

[0027] 1) FeCl 3 ·6H 2 O and anhydrous sodium acetate are dissolved in ethylene glycol to obtain a uniform and transparent mixed solution;

[0028] 2) Add the surface modifier glutaraldehyde into the prepared mixed solution, stir and sonicate to obtain a homogeneous mixed solution;

[0029] 3) The mixed liquid prepared in step 2) is subjected to solvothermal reaction in an autoclave, the reaction temperature is 150-220°C, the reaction time is 6-38 hours, the reaction pressure is 1-6Mpa, and naturally cooled to room temperature after the reaction;

[0030] 4) In the presence of an external magnetic field, the solid compounds in the reaction product were separated, washed with deionized water and absolute ethanol, and vacuum-dried to obtain magnetic nanoparticles modified by surface aldehyde groups.

Embodiment 1

[0032] A preparation method of surface aldehyde functionalized magnetic nanoparticles, comprising the following steps:

[0033] (a) Weigh FeCl respectively 3 ·6H 2 O0.5g and 1.8g of anhydrous sodium acetate are placed in a 50mL beaker, add 15mL of ethylene glycol, and stir to obtain a uniform and transparent mixed solution.

[0034] (b) Measure 1.71 mL of glutaraldehyde, a surface modifier having a characteristic functional group aldehyde group, and add it to the solution obtained in step (a), stir and sonicate to obtain a homogeneous mixed solution.

[0035] (c) Transfer the solution obtained in step (b) to a sealed 30mL stainless steel autoclave with tetrafluoroethylene lining for solvothermal reaction. The reaction temperature is 200°C, the reaction time is 12h, and the reaction pressure is 1-6Mpa. End naturally cooled to room temperature.

[0036] (d) After the solution is cooled to room temperature, in the presence of an external magnetic field, separate the solid comp...

Embodiment 2

[0038] A preparation method of surface aldehyde functionalized magnetic nanoparticles is as follows:

[0039] (a) Weigh FeCl respectively 3 ·6H 2 O0.5g and 1.8g of anhydrous sodium acetate were placed in a 50mL beaker, and 30mL of ethylene glycol was added, and stirred to obtain a uniform and transparent mixed solution.

[0040] (b) Measure 3.43 mL of glutaraldehyde, a surface modifier with characteristic functional group aldehyde groups, and add it to the solution obtained in step (a), stir and sonicate to obtain a uniform turbid solution.

[0041] (c) Transfer the solution obtained in step (b) to a sealed 30mL stainless steel autoclave with tetrafluoroethylene lining for solvothermal reaction. The reaction temperature is 220°C, the reaction time is 6h, and the reaction pressure is 1-6Mpa. End naturally cooled to room temperature.

[0042] (d) After the solution is cooled to room temperature, in the presence of an external magnetic field, separate the solid compound in (c)...

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Abstract

The invention discloses a preparation method for magnetic nanoparticles with surface aldehyde group functionalization. FeCl3.6H2O and anhydrous sodium acetate are dissolved in ethylene glycol, and a uniform and transparent mixed solution is prepared; The surface modification agent glutaraldehyde is added in the prepared mixed solution, after stirring and ultrasonic treatment, a uniform mixed solution is prepared; the prepared mixed solution is subjected to a solvothermal reaction in a high pressure reactor, after the reaction is over, the above mixture is cooled naturally to room temperature; In presence of an applied magnetic field, solid-state compounds are separated from the reaction products. The magnetic nanoparticles with surface aldehyde group functionalization have superparamagnetism, and can be dispersed in a solution steadily. Rapid separation and enrichment can be achieved by utilization of an applied magnetic field. The magnetic nanoparticles can be regenerated and used repeatedly, and has strong magnetism. Because of large specific surface area and surfaces with aldehyde group active groups, the magnetic nanoparticles can be used for separation of biomacromolecules and drug targeting delivery and adsorption.

Description

technical field [0001] The invention belongs to the technical field of nanometer materials, and relates to a preparation method of magnetic nanoparticles whose surface is functionalized with aldehyde groups. Background technique [0002] In recent years, magnetic nanomaterials have received great attention from scientists. Because of their nano-size effect, biocompatibility, magnetic responsiveness and other characteristics, they can be easily guided or separated under the action of an external magnetic field, so they are It is widely used in magnetic targeted drug delivery, immunoassay, immobilized enzyme, separation of cells or DNA, environmental monitoring and other fields. However, there are the following problems in the practical application of magnetic nanoparticles: (1) There is a strong magnetic dipole attraction between the magnetic nanoparticles, which makes it easy to agglomerate to form larger aggregates. (2) Magnetic nanoparticles contain Fe 2+ , low chemical ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J20/02B01J20/30H01F1/00
Inventor 高瑞霞郝旖张军杰唐玉海
Owner XI AN JIAOTONG UNIV
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