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Preparation method of dual-template molecular imprinting adsorption and extraction stirring rod

A technology of molecular imprinting and template molecules, applied in selective adsorption, chemical instruments and methods, ion exchange, etc., can solve the problem of molecular imprinting polymers limited to a single template molecule, and achieve the effect of enriching types

Inactive Publication Date: 2014-04-23
KUNMING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] The purpose of the present invention is to provide a preparation method of a double-template molecularly imprinted adsorption extraction stirring rod, which is used for the selective extraction of two template molecules and their structural analogues, and solves the application problem of common molecularly imprinted polymers limited to a single template molecule , including the following steps:

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  • Preparation method of dual-template molecular imprinting adsorption and extraction stirring rod
  • Preparation method of dual-template molecular imprinting adsorption and extraction stirring rod
  • Preparation method of dual-template molecular imprinting adsorption and extraction stirring rod

Examples

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Embodiment 1

[0034] The preparation method of the double-template molecularly imprinted adsorption extraction stirring rod described in this example is as follows: figure 1 shown, including the following steps:

[0035] (1) Clean the sampling capillary with an inner diameter of 0.9 mm with distilled water, dry it at 100 °C, and sinter one end of the sampling capillary on the flame of an alcohol lamp;

[0036] (2) Dissolve the mixed template molecules of bisphenol A and estradiol and methacrylic acid in a methanol-acetonitrile mixed solution for pre-assembly to obtain a pre-assembly solution. The pre-assembly time is 11 hours. The schematic diagram of the pre-assembly is as follows figure 1 As shown, the molar concentration of bisphenol A is 0.05 mol / L, the molar concentration of estradiol is 0.05 mol / L, the molar concentration of functional monomer is 0.30 mol / L, and the volume ratio of methanol and acetonitrile is 1:1;

[0037](3) Add ethylene glycol dimethacrylate and azobisisobutyroni...

Embodiment 2

[0049] The preparation method of the dual-template molecularly imprinted adsorption extraction stirring rod described in this example comprises the following steps:

[0050] (1) Clean the spotting capillary with an inner diameter of 0.9 mm with distilled water, dry it at 100 °C, and sinter one end of the spotting capillary on the flame of an alcohol lamp;

[0051] (2) Dissolve the mixed template molecules of bisphenol A and estradiol and methacrylic acid in a methanol-acetonitrile mixed solution for pre-assembly to obtain a pre-assembly solution. The pre-assembly time is 12 hours, and the molar concentration of bisphenol A is 1 mol / L, the molar concentration of estradiol is 1 mol / L, the molar concentration of functional monomer is 0.60 mol / L, and the volume ratio of methanol and acetonitrile is 1:1;

[0052] (3) Add ethylene glycol dimethacrylate and azobisisobutyronitrile to the pre-assembly solution obtained in step (2) to obtain a polymerization solution, and the molar conc...

Embodiment 3

[0060] The preparation method of the dual-template molecularly imprinted adsorption extraction stirring rod described in this example comprises the following steps:

[0061] (1) Clean the spotting capillary with an inner diameter of 1.1mm with distilled water, dry it at 150°C, and sinter one end of the spotting capillary on the flame of an alcohol lamp;

[0062] (2) Dissolve the mixed template molecules of bisphenol A and estradiol and methacrylic acid in a methanol-acetonitrile mixed solution for pre-assembly to obtain a pre-assembly solution. The pre-assembly time is 10 hours, and the molar concentration of bisphenol A is 0.025 mol / L, the molar concentration of estradiol is 0.025 mol / L, the molar concentration of functional monomer is 0.15 mol / L, and the volume ratio of methanol and acetonitrile is 1:1;

[0063] (3) Add ethylene glycol dimethacrylate and azobisisobutyronitrile to the pre-assembly solution obtained in step (2) to obtain a polymerization solution, and the mola...

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Abstract

The invention discloses a preparation method of a dual-template molecular imprinting adsorption and extraction stirring rod and belongs to the technical field of adsorbing and separating materials and sample pretreatment. The preparation method comprises the following steps: with a sample-application capillary tube as a base body of the dual-template molecular imprinting adsorption and extraction stirring rod, activating the outer surface of the sample-application capillary tube by a silylating reagent; performing polymerization reaction on molecularly imprinted polymers with the capillary tube, and coating the molecularly imprinted polymers for multiple times till the thickness is proper; arranging a magnetic core inside the capillary tube, cutting the capillary tube to proper length, and then sealing the ends of the capillary tube; and eluting template molecules, thus obtaining the dual-template molecular imprinting adsorption and extraction stirring rod. The prepared dual-template molecular imprinting adsorption and extraction stirring rod can be used for selectively separating and enriching bisphenol A and estradiol simultaneously and also can be used for selectively extracting other phenolic estrogens with similar structures.

Description

technical field [0001] The invention relates to a preparation method of a double-template molecularly imprinted adsorption extraction stirring rod, which belongs to the technical field of adsorption separation materials and sample pretreatment methods. Background technique [0002] Adsorption extraction stirring rod is a novel form of sample pretreatment microextraction. Its extraction principle is similar to solid phase microextraction. Adsorption extraction stirring rod can immobilize a thicker coating, and its adsorption extraction capacity is much higher than that of solid phase microextraction. In addition, the adsorption extraction stirring bar can also extract the target substance while stirring, which can avoid the competitive adsorption of the external stirring bar. [0003] The core of the adsorption extraction stirring rod is the extraction coating. At present, there are only a few commercial coatings such as polydimethylsiloxane, ethylene glycol siloxane and poly...

Claims

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Application Information

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IPC IPC(8): B01J20/26B01J20/28B01J20/32B01D15/08
Inventor 许志刚杨再磊刘智敏何素琼
Owner KUNMING UNIV OF SCI & TECH
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