Instrument for capturing free thrombi

A device and thrombus technology, which is applied in the field of free thrombus capturing devices, can solve problems such as blood flow obstruction, and achieve the effect of reducing the burden and prolonging the usable time.

Inactive Publication Date: 2014-04-30
井上宽治 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The blood coagulation reaction is an indispensable reaction for leading bleeding caused by injury to hemostasis, but on the other hand, in percutaneous treatment using various devices such as artificial blood vessels, bl

Method used

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  • Instrument for capturing free thrombi
  • Instrument for capturing free thrombi
  • Instrument for capturing free thrombi

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0077] (Example 1: combination of amino-polyether modified silicone and argatroban)

[0078] Take 5 mmol of argatroban and add it to an eggplant-shaped flask, add 10 mL of dehydrated dimethylformamide (hereinafter referred to as "dehydrated DMF") to dissolve, and then ice-cool the eggplant-shaped flask, and simultaneously add 10 mL of 4N hydrochloric acid / 1, 4-Dioxane (Toyo Kasei Co., Ltd.), stirred for 1 hour. Next, the solvent was distilled off with a rotary evaporator, and then dried in a vacuum dryer overnight, and 25 mL of dehydrated DMF was added to the obtained dried product to prepare an argatroban hydrochloride / dehydrated DMF solution.

[0079] According to the portion shown in Table 1, take argatroban hydrochloride / dehydrated DMF solution and join in the two-necked flask, stir under ice-cold, add dicyclohexylcarbodiimide (hereinafter referred to as "DCC") / dehydrated DMF solution and 4-hydroxybenzotriazole (hereinafter referred to as "HOBt") / dehydrated DMF solution, ...

Embodiment 2～13

[0084] In addition to changing the molar ratio of DCC, HOBt and polyether-modified silicone (X-22-3939A) relative to argatroban hydrochloride and the volume ratio of dehydrated DMF and polyether-modified silicone, according to Example 1 The same method was used to obtain the compounds of Examples 2-13 respectively, and their antithrombin ability was determined. See Table 1 for the molar ratios of DCC, HOBt and polyether-modified silicone (X-22-3939A) relative to argatroban hydrochloride and the measurement results of the antithrombin abilities of the compounds of Examples 2-13.

[0085] [Table 1]

[0086]

[0087] It should be noted that for the polyether-modified silicone (X-22-3939A), the antithrombin ability was also measured, but the value was not different from the value of blank distilled water, and it can be confirmed that the polyether-modified silicone itself Does not have antithrombin ability.

[0088] (Measurement of the thrombin inhibition constant of embodime...

Embodiment 14

[0097] (Example 14: Combination of vinyl acetate-vinylpyrrolidone copolymer and argatroban)

[0098] Take 14.9g of tetrahydrofuran, 11.5g of vinyl acetate, 10.8g of N-vinylpyrrolidone, 0.028g of 2-aminoethanethiol and 0.016g of azobisisobutyronitrile into a screw bottle, seal it, and then irradiate with ultrasound for 10 minutes. Open the screw bottle temporarily, blow in argon gas for 10 minutes, seal it again, and then immerse the screw bottle in a hot water bath at 60°C for 1 hour while stirring, and then immerse it in a hot water bath at 70°C for 6 hours to make the acetic acid Copolymerization of vinyl esters and vinylpyrrolidone. 80 mL of methanol was added to the reaction liquid, the resulting solution was added to about 5 times the amount of diethyl ether, and the supernatant was removed. The cleaning operation of adding diethyl ether again and removing the supernatant was repeated three times, followed by drying under reduced pressure to obtain a vinyl acetate-vinylp...

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Abstract

The purpose of the present invention is to provide an instrument for capturing free thrombi, which can inhibit a blood coagulation reaction at a primary hemostasis stage in which platelet is involved or a coagulated thrombi formation stage in which a blood coagulation factor is involved, whereby it becomes possible to secure the capture of free thrombi and to prolong the usable time of the instrument. The present invention provides: an instrument for capturing free thrombi, in which a compound having an anti-thrombin capability is immobilized on the surface thereof; and a method for capturing free thrombi, which comprises capturing free thrombi in blood in vivo using the instrument for capturing free thrombi.

Description

technical field [0001] The present invention relates to a device for capturing free thrombus. Background technique [0002] In recent years, percutaneous treatment has been adopted in the treatment of aortic diseases, that is, various devices such as artificial blood vessels and stents are inserted and indwelled in the lesion site through a catheter introduced into the human body from the incision of the arterial vessel. However, in such a percutaneous treatment, thrombus dissociates from the inner wall of the blood vessel at the brittle lesion, blocks the capillary blood vessel at the peripheral side, and there is a risk of necrosis of the tissue in front of it. And, especially when the clot is clogged in the carotid artery extending to the head, life-threatening conditions can arise. [0003] In order to avoid such dangers, people have developed a free thrombus catcher, which is placed on the more distal side of the diseased part where various devices such as artificial b...

Claims

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Application Information

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IPC IPC(8): A61L31/00A61B17/00
CPCA61L33/064A61L2400/18A61L33/06A61F2/013A61L2300/606A61F2/95A61L33/0041A61L33/068A61L2300/42A61L31/04A61L31/06A61L31/16A61F2230/0006A61L31/10A61B17/00234A61F2002/018A61F2230/0067C08L67/02C08L83/04A61B17/00A61L31/00A61L2420/02
Inventor 井上宽治坂口博一阪口有佳棚桥一裕
Owner 井上宽治
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