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Gadolinium (III)-carbon quantum dot and preparation method thereof, and application thereof in magnetic resonance-fluorescence double-modal imaging probe

A technology of carbon quantum dots and mass concentration, which is applied in the application field of gadolinium-carbon quantum dots and its preparation, magnetic resonance-fluorescence dual-mode imaging probes, can solve the problems of complex preparation process, achieve simple preparation method, The effect of enhancing the magnetic resonance signal and requiring less equipment

Inactive Publication Date: 2014-05-07
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The precursor selected by this technology is an independent carbon source and gadolinium source, and the preparation process is complicated, and the precursor needs to undergo a reaction in an aqueous solution and a post-treatment process involving complex organic reagents before it can be pyrolyzed.

Method used

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  • Gadolinium (III)-carbon quantum dot and preparation method thereof, and application thereof in magnetic resonance-fluorescence double-modal imaging probe
  • Gadolinium (III)-carbon quantum dot and preparation method thereof, and application thereof in magnetic resonance-fluorescence double-modal imaging probe
  • Gadolinium (III)-carbon quantum dot and preparation method thereof, and application thereof in magnetic resonance-fluorescence double-modal imaging probe

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Effect test

Embodiment 1

[0035] 1) Using gadolinium diethylenetriamine pentaacetate as a precursor, heat it in a high-temperature resistance furnace with a preset temperature rise program and continuously feed nitrogen to generate pyrolysis products. The temperature rise program of the high temperature resistance furnace is set as: increase the temperature from room temperature to 200 °C at a rate of 1 °C / min, keep at 200 °C for 5 hours, and finally cool down to room temperature.

[0036] 2) Add 2 parts of the pyrolysis product to 20 parts of 0.01M aqueous sodium hydroxide solution, and then place it in an ultrasonic cleaner (power 300W) for dispersive treatment for 20 minutes to obtain a suspension.

[0037] 3) The suspension is filtered through an aqueous microporous membrane with a pore size of 0.22 μm to obtain a filtrate containing gadolinium (Ш)-carbon quantum dots. During the suction filtration process, the filter cake was continuously washed with a 0.01M aqueous sodium hydroxide solution until...

Embodiment 2

[0040] 1) Using gadolinium diethylenetriamine pentaacetate as a precursor, place it in a high-temperature resistance furnace with a preset temperature rise program and continuously feed a mixed gas of helium and nitrogen for heat treatment to generate pyrolysis products. The temperature rise program of the high temperature resistance furnace is set as follows: increase the temperature from room temperature to 400 °C at a rate of 5 °C / min, keep at 400 °C for 3 hours, and finally cool down to room temperature.

[0041] 2) Add 2 parts of the pyrolysis product to 30 parts of 0.05M sodium hydroxide aqueous solution, and then place it in an ultrasonic cleaner (power 400W) for dispersive treatment for 30 minutes to obtain a suspension.

[0042] 3) The suspension is filtered through an aqueous microporous membrane with a pore size of 0.45 μm to obtain a filtrate containing gadolinium (Ш)-carbon quantum dots. During the suction filtration process, the filter cake was continuously washe...

Embodiment 3

[0045] 1) With 1 part of gadolinium diethylenetriamine pentaacetate, 1 part of gadolinium ethylenediamine tetraacetate and 1 part of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetracarboxylic The mixture of gadolinium acid is the precursor, which is placed in a high-temperature resistance furnace with a preset temperature rise program for heat treatment to generate pyrolysis products. The temperature rise program of the high temperature resistance furnace is set as: increase the temperature from room temperature to 450°C at a rate of 30°C / min, keep at 450°C for 3 hours, and finally cool down to room temperature.

[0046] 2) Add 2 parts of the pyrolysis product to 30 parts of 0.05M potassium hydroxide aqueous solution, and then place it in an ultrasonic cleaner (600W power) for dispersive treatment for 60 minutes to obtain a suspension.

[0047] 3) The suspension is filtered through an aqueous microporous membrane with a pore size of 0.65 μm to obtain a filtrate containing gadolin...

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Abstract

The invention discloses a gadolinium (III)-carbon quantum dot and a preparation method thereof, and application thereof in a magnetic resonance-fluorescence double-modal imaging probe, and belongs to the technical field of preparation of a medical image material. The method comprises the following steps: 1) carrying out thermal treatment on a precursor, and generating a pyrolysis product; 2) adding the pyrolysis product to an alkaline solution to carry out ultrasonic dispersing treatment, so as to obtain turbid liquid; 3) filtering the turbid liquid by a waterborne microporous filter membrane to obtain filtrate containing the gadolinium (III)-carbon quantum dot; (4) dialyzing and drying the filtrate containing the gadolinium (III)-carbon quantum dot to obtain the gadolinium (III)-carbon quantum dot. The method is simple and feasible, low in demands on equipment, easy to control reaction conditions, and free of participation of an organic reagent; the rolled gadolinium (III)-carbon quantum dot can be evenly and stably dispersed into water, has excellent magnetic resonance response and photoluminescence properties, and is applicable to the magnetic resonance-fluorescence double-modal imaging probe.

Description

technical field [0001] The invention belongs to the technical field of preparation of medical imaging materials, and in particular relates to a gadolinium (Ш)-carbon quantum dot and its preparation method and its application in a magnetic resonance-fluorescence dual-mode imaging probe. Background technique [0002] Magnetic resonance-fluorescence dual-modal molecular imaging technology overcomes the limitations of single molecular imaging technology, complements the advantages of different molecular imaging technologies, and greatly broadens the research scope and application prospects of molecular imaging technologies. Magnetic resonance imaging (MRI), which is widely used in clinical practice, can provide high-resolution tissue information and three-dimensional structural imaging without using radioactive substances as contrast agents, but its sensitivity is low, making it difficult to accurately predict early-stage lesions and minor lesions. Fluorescence imaging technique...

Claims

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Application Information

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IPC IPC(8): C09K11/77G01N21/64A61K49/06B82Y20/00
Inventor 井新利任先艳刘丽华李瑜
Owner XI AN JIAOTONG UNIV
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