44 results about "Resonance fluorescence" patented technology

Methods and systems for detecting potential items of interest in target samples, using nuclear resonance fluorescence, utilize incident photon spectra that are narrower than traditional bremsstrahlung spectra but overlap nuclear resonances in elements of interest for purposes of detection, such as but not limited to the detection of threats in luggage or containers being scanned.

Quantum resonance fluorescent microscope systems for detecting component substances in a specimen are described. The systems are based on exciting the sample containing the material with a femtosecond to nanosecond probe pulse of collimated light, which is tailored to optimize detection of a given material by separating the probe pulse into component features of frequency, polarization, phase and / or amplitude. The component features are independently shaped and formed into a composite pulse selected to optimize a signature response pulse received from the material. In some cases, two independently re-shaped pulses are combined, where one re-shaped pulse has two mixed polarization states and the other re-shaped pulse is linearly polarized. These two pulses are made to intersect at an angle of 90 degrees so that the combined pulse has electric field in each of the XYZ axes. Selection of the appropriate shapes for the component features of the pulses for a given material is accomplished by testing variations in the features on the material, assigning a fitness value to variants that tend to optimize a distinctive spectral response from the material, and using a genetic algorithm to select the combination of component features that enhances the distinctiveness of the response received over a typical background.

A grating-based sensor is disclosed that has a grating structure constructed and designed for both evanescent resonance (ER) fluorescence detection and label-free detection applications. One and two-dimensional gratings are also disclosed, including gratings characterized by unit cells with central posts, central holes, and two-level, two-dimensional gratings. A readout system for such sensors is also disclosed. Various applications for the biosensors are described, including cell-based assays for assessing the effect of drug compounds, proteins, peptides and other materials on cell function. A biosensor embodiment optimized for a luminescent response at two different wavelengths is also described. Such luminescent response could be produced by fluorescence (either native or from an attached fluorophore), phosphorescence, chemi-luminescence, or other luminescence technology. Two different luminescence technologies could be combined on the same biosensor chip.

The invention discloses a gadolinium (III)-carbon quantum dot and a preparation method thereof, and application thereof in a magnetic resonance-fluorescence double-modal imaging probe, and belongs to the technical field of preparation of a medical image material. The method comprises the following steps: 1) carrying out thermal treatment on a precursor, and generating a pyrolysis product; 2) adding the pyrolysis product to an alkaline solution to carry out ultrasonic dispersing treatment, so as to obtain turbid liquid; 3) filtering the turbid liquid by a waterborne microporous filter membrane to obtain filtrate containing the gadolinium (III)-carbon quantum dot; (4) dialyzing and drying the filtrate containing the gadolinium (III)-carbon quantum dot to obtain the gadolinium (III)-carbon quantum dot. The method is simple and feasible, low in demands on equipment, easy to control reaction conditions, and free of participation of an organic reagent; the rolled gadolinium (III)-carbon quantum dot can be evenly and stably dispersed into water, has excellent magnetic resonance response and photoluminescence properties, and is applicable to the magnetic resonance-fluorescence double-modal imaging probe.

The invention relates to a whole day photon counting laser radar device and a method, which comprises an emission system consisting of a laser, an expander and a reflector, a receiving system consisting of a telescope, an optics filter and a photoelectric detector, and a central control device connected with the photoelectric detector with a software. The invention is characterized in that the wavelength of the laser and the optics filter are chosen to match with the fraunhofer absorption line wavelength of the solar spectrum; the intense absorption is adopted to reduce the intensity of a solar back light by 80 to 90 percent and to lead the laser radar to have good photon counting ability under the back light condition in days. The invention is characterized in that the day detection signal-noise ratio and the detection distance are greatly improved, which effectively improves the whole day high-performance working ability. Besides, the invention is widely suitable for the laser radarof detecting weak signal such as Mie dispersion, Rayleigh dispersion, Raman dispersion and atom resonance fluorescence, etc.

The invention discloses an excited state atom filter receiving device for pumping laser atom frequency stabilization. The device consists of a receiving telescope (1), an atom filter unit (2), a first photoelectric detector (3) and an atom frequency stabilization pumping laser unit (4). Resonance fluorescence generated by atoms is used for carrying out feedback frequency stabilization on a pumping laser, the work frequency of the pumping laser is stable without drifting, and further, low excited state atom number density and super-fine energy level distribution is stable, so the transmission spectrum type stability and the transmittance of an excited state atom filter are improved.

A method for classifying a sample based upon a complete spectral analysis. The sample is illuminated with penetrating radiation and an initial complete spectral analysis is performed based on spectral resolution of resonant fluorescence lines emitted at the surface, or within the volume, of the sample. If the initial complete spectral analysis yields the composition of the sample to within acceptable limits, analysis values are output to the user. Otherwise, further analysis, informed by the results if the initial complete spectral analysis, is performed.

A method for classifying a sample based upon a complete spectral analysis. The sample is illuminated with penetrating radiation and an initial complete spectral analysis is performed based on spectral resolution of resonant fluorescence lines emitted at the surface, or within the volume, of the sample. If the initial complete spectral analysis yields the composition of the sample to within acceptable limits, analysis values are output to the user. Otherwise, further analysis, informed by the results if the initial complete spectral analysis, is performed.

The invention discloses a magnetic resonance, a fluorescent double-developing nanometer gel, a probe and a preparation method of the gel. The method comprises the following steps: preparing a magnetic resonance developing functional nanometer gel by coupling a nanometer gel with the nuclear magnetic developing molecules to prepare a magnetic resonance and fluorescent double-developing functional nanometer gel by coupling with the fluorescent molecules. According to the invention, the double-developing of infrared developing and magnetic resonance developing is realized and complementary high-resolution magnetic resonance developing and high-sensitivity fluorescent developing are combined with each other. Besides, the nanometer gel has response to reducing matters and a weak acid environment, can be decomposed in a tumor environment so as to promote the mutation of fluorescent and magnetic resonance developing signals and has an excellent application prospect in high-sensitivity diagnosis for tumors.

The invention discloses an adaptive narrow-linewidth semiconductor laser frequency stabilization device comprising a semiconductor laser, a beam collimating system, volume gratings, a heating device, an atomic gas chamber, a fluorescence measurement device and a signal processing and control system. The semiconductor laser, the beam collimating system and the volume gratings form an external chamber. The external chamber emergent laser spectrum is narrowed in comparison with that of the freely operating semiconductor laser 1 under the volume grating narrowband backward diffraction feedback effect. A part of emergent laser is incident to the atomic gas chamber to excite alkali metal atoms to generate resonance fluorescence. The fluorescence measurement system detects a fluorescence signal and inputs the fluorescence signal to the signal processing and control system. The signal processing and control system changes the grating temperature by regulating the heating power of the heating device in the volume gratings so as to change the emergent laser central wavelength. The adaptive narrow-linewidth semiconductor laser frequency stabilization device has the advantages of effectively enhancing pumping system spectrum stability, use convenience and environment adaptability.

The invention relates to an on-line in-water heavy metal monitor based on atomic fluorescence spectroscopy. The monitor comprises a feeding-reacting system, an atomization system and an optical system, wherein the feeding-reacting system is used for quantitatively introducing a water sample or a standard solution into an instrument to be reacted with a reducing agent so as to generate heavy metal hydride in a gas state; the heavy metal hydride is carried by a carrier gas and enters the automation system after being subjected to water-gas separation; the hydride in the gas state is decomposed into metal atoms at appropriate temperature; under the triggering action of a specific wavelength triggering light of the optical system, the metal atoms in the gas state generate resonance or non-resonance fluorescence; and by measuring the fluorescence intensity, the quantitative result of the heavy metal element is obtained. The advantages of the atomic fluorescence spectroscopy analysis principle is sufficiently utilized, the rapid high-sensitivity on-line monitoring on the in-water heavy metal elements is realized, and the problem of analysis interference is avoided to the maximum extent.

The invention discloses a resonance fluorescence scattering laser radar laser emission power optimization control device and control method. The method comprises the following steps: acquiring a resonance fluorescence excitation saturation laser power threshold P0 of a detected metal layer, acquiring an echo signal corresponding to a clear sky time laser radar when the output power is P0, and acquiring a monopulse photon counting signal critical value PC0 at a low-altitude reference height Z0; comparing the monopulse photon counting signal PC1 on the reference height Z0 acquired in real time with a critical value PC0, and judging whether the current laser emission power can cause a metal layer fluorescence excitation saturation effect or low-efficiency excitation or not; and outputting a laser emission power control signal according to a judgment result of whether the laser emission power causes a metal layer fluorescence excitation saturation effect or low-efficiency excitation. According to the invention, the laser emission power can be optimized according to different attenuation degrees of the low-altitude atmosphere to the emitted laser under the real-time weather condition, and efficient and accurate metal layer detection can be realized.

The invention discloses a nondestructive container detection method based on the Compton gamma light-nuclear resonance fluorescence. The method comprises the following steps: (1) putting a Compton gamma light source on one side of a container to supply gamma light beams, and putting energy spectrometers on the two sides of the container, wherein included angles of 90 degrees and -90 degrees are formed between the energy spectrometers in the horizontal plane and the direction of an incident gamma beam respectively for performing energy spectrum measurement; (2) identifying nuclear resonance fluorescence characteristic peaks of various nuclides according to the distribution of measured energy spectra so as to further obtain possible nuclide type information in the container; (3) putting a flow intensity detector on the other side, opposite to the side in which the light source is arranged, of the container, and measuring the number of rays passing through different container positions by horizontally and vertically scanning the container to obtain position information and ray intensity information; and (4) putting nuclide evidential foils with different thicknesses between the container and the flow intensity detector, repeatedly executing the step (3), and comparing the ray intensity value with the ray intensity value measured in the step (3). According to the method, the various nuclides can be identified quickly and accurately, the signal to noise ratio is improved, the photographic reproduction dosage is reduced, and the scanning time is shortened.

The broadening of the lines in NRF from an isotope that is part of a material may be due to several causes: the temperature of the material, the molecular structure of the material and the crystalline structure of the material. By measuring the broadening caused by the molecular structure and the crystalline structure the material itself can be identified. The exact energy of the lines in NRF may also depend on the nature of the crystalline and molecular structure of the material. By measuring the changes in the energy of the NRF lines caused by the structure of the material the material itself may be identified. These techniques provide a “fingerprint” of the molecule or crystal that is involved. The fingerprint information may be used to determine a potential threat.

The invention discloses a nanometer probe for testing DNA through combination of fluorescence intensity and fluorescence polarization, and belongs to the technical field of nucleic acid detection. The nanometer probe comprises fluorescent protein, a capturing probe, a reporting probe, and nanometer gold particles. The fluorescent protein is taken as a donor and connected with the capturing probe; the nanometer gold particles are taken as a receptor and connected with the reporting probe; the capturing probe and the reporting probe form an energy transfer donor and receptor pair through complementary pairing of parts of basic groups; and the capturing probe and target DNA are in complete complementary pairing. The nanometer probe is combined with fluorescence intensity parameters and fluorescence polarization parameters with high sensitivity, thereby achieving non-amplification DNA high-sensitivity detection; and through utilization of opposite variation tendencies of fluorescence intensity and fluorescence polarization in a process of forming and vanishing resonance fluorescence energy transfer, a specific value of fluorescence intensity to fluorescence polarization is introduced, and a detection signal of DNA is amplified.

The invention provides an intermediate layer magnetic field remote sensing device based on gated photon counting, and relates to the field of intermediate layer magnetic field laser remote sensing. The device comprises a continuous wave laser (1), an acoustic-optical modulation unit (2), an emission telescope (3), a reception telescope (4), a detection unit (5), an FPGA gated photon counting unit(6) and a computer (7). A pulse signal modulated by laser intensity is generated by employing an FPGA, and the function of gated photon counting is realized. Gated time delay is adjusted, resonance fluorescence emitted by a neutral atom layer of an intermediate layer is received, the repetition frequency of a pulse is scanned, and a magnetic resonance signal is obtained. The magnetic field of theintermediate layer is remotely detected to provide a new tool for drawing of a magnetic field structure of an earth lithosphere and long-term monitoring of the ionosphere current of a polar region. The intermediate layer magnetic field measuring scheme based on gated photon counting can only receive echo waves from the neutral atom layer at the specific height, and the measurement of the magneticfield of the intermediate layer with distinguishable height can be realized.

The present invention dislcoses a kind of double wavelength laser radar capable of detecting high altidude atmosphere in wide 30-110 Km range. In the hardware configuration basically the same as that in a common sodium layer fluorescent laser radar, the laser radar combines the two operating mechanism of Rayleigh scattering and sodium layer resonance fluorescence. By means of double wavelength emission and spitted spectroscopic double fiber reception, one laser radar can be used to detect the atmosphere in both middle altitude and high altitude of wide 20-110 Km range simultaneously and complete all the functions of both Rayleigh scattering laser radar and sodium layer resonance fluorescence laser radar.

The invention relates to a compound, a preparation method thereof and application of the compound in uranium analysis. A structural formula of the compound is shown as a formula I. The preparation method of the compound includes the steps of adding benzodipyrrole carboxaldehyde and o-phenylenediamine into a dichloromethane / methanol solution, dropwise adding trifluoroacetic acid, and then obtainingthe compound, wherein the equivalence ratio of benzodipyrrole carboxaldehyde to o-phenylenediamine is 1:(0.8-1.5). The compound can be combined with uranyl and europium to form a dinuclear complex with strong resonance fluorescence. Since the strong resonance fluorescence can be generated due to positive ion-positive ion interaction when uranyl gets close to europium, the compound can be used forquantitative detection analysis of uranium. The formula I is shown in the description.

The invention discloses a spectral measurement method based on a wide-spectrum light source and spectral scanning laser radar. The measurement method comprises the following steps: adjusting the transmission wavelength of the adjustable filter in a time-sharing manner; under a specific transmission wavelength, filtering laser pulses from the wide-spectrum pulse laser through an adjustable filter,emitting the wide-spectrum pulse laser to a detection target after being subjected to pulse excitation amplification, filtering echo signals through the same adjustable filter to obtain signals to bedetected, and measuring echo intensity of the signals to be detected; and measuring echo intensities under different transmission wavelengths to obtain a detection target spectrum. The related spectrum scanning laser radar adopts a time division multiplexing technology and an optical switch gating technology to support the implementation of the method. According to the invention, the solar and skybackground noise can be filtered to the greatest extent, the Brillouin signal, the Raman signal and the resonance fluorescence signal are isolated, the detection spectrum purity and the signal-to-noise ratio are improved, and the system integration and stability are improved by adopting an all-fiber structure. Spectral signals of an underwater profile can be extracted, and the method is an important supplement based on passive water color remote sensing at present.

The invention discloses an excited state atom filter receiving device for pumping laser atom frequency stabilization. The device consists of a receiving telescope (1), an atom filter unit (2), a first photoelectric detector (3) and an atom frequency stabilization pumping laser unit (4). Resonance fluorescence generated by atoms is used for carrying out feedback frequency stabilization on a pumping laser, the work frequency of the pumping laser is stable without drifting, and further, low excited state atom number density and super-fine energy level distribution is stable, so the transmission spectrum type stability and the transmittance of an excited state atom filter are improved.

The invention provides a novel laser sodium guide star system. The novel laser sodium guide star system comprises a laser transmitting module, a signal receiving module, a system control module and a near space vehicle platform. The near space vehicle platform is arranged in the airspace which is 20km above the ground and below the sodium layer in the upper atmosphere. The laser transmitting module is arranged on the near space vehicle platform. Lasers transmitted by the laser transmitting module irradiate sodium atoms in the sodium layer in the upper atmosphere to generate resonance fluorescence, a sodium guide star is obtained, and the lasers are then received by the signal receiving module. The laser sodium guide star system is constructed on the basis of the near space vehicle platform, the luminance of the laser sodium guide star is greatly improved on the basis of existing laser source power, the influences of atmosphere turbulences on light beam transmission are effectively avoided, the obtained laser sodium guide star is higher in position stability and small in error, the correction effect and work performance of a self-adaption system can be improved, and the novel laser sodium guide star system has great market popularization value.

The invention belongs to the technical field of spectral analysis, and particularly relates to a chromatic dispersion type AFS light source scattering interference deduction method based on a DMD. Themethod comprises the steps of determining a light source characteristic spectral line of an excitable relatively strong non-resonance fluorescence line of a to-be-measured element; selecting a narrow-band pass filter corresponding to the central wavelength according to the determined light source characteristic spectral line, placing the narrow-band pass filter in front of an atomizer to ensure that only the wavelength in a band-pass range of the narrow-band filter in an excitation light source can penetrate through the filter, and generating corresponding resonance fluorescence and non-resonance fluorescence through the atomizer; controlling a digital micromirror to perform full spectrum measurement, and confirming a range of corresponding pixels of non-resonance fluorescence line information which participates in detection on the digital micromirror; and measuring all non-resonance fluorescence intensities according to the range, and performing summation to obtain a fluorescence intensity value of the to-be-measured element. According to the method, the scattering interference of the light source can be effectively avoided, so that the accuracy of a quantitative detection resultof the to-be-measured element is improved.

The invention relates to a nuclear resonance fluorescence-based pulse gamma ray energy spectrum measuring system and method. The device comprises lead collimators, a HPGe detector and a specific target sheet; the lead collimators and the specific target sheet are sequentially disposed in the beam direction of pulse gamma rays to be measured; the HPGe detector is located to one side of the pulse gamma rays to be measured; and an included angle between the HPGe detector and the beam direction ranges from 90 degrees to 120 degrees; a plurality of target materials are stacked so as to form the specific target sheet; and the energy level of each target material is within the energy range of the pulse gamma rays to be measured. The method includes the following steps that: 1) a HPGe detector isadopted to detect the number R of photons emitted by the pulse gamma rays to be measured during nuclear resonance fluorescence; 2) photon density is calculated; and 3) and Gaussian fitting is performed on the basis of the photon density, so that the energy spectrum distribution diagram of the pulse gamma rays to be measured is obtained. With the method of the invention adopted, a pulse gamma ray energy spectrum measurement experiment is simple to set, later-stage calculation is simple, and measurement accuracy is high.

The invention relates to a heterogeneous photocatalysis resonance fluorescence method for accurately detecting trace uranium in an environmental water sample. The method mainly comprises the following steps: quantitatively separating the trace uranyl in a complex environmental water sample by using solid phase extraction particles UMIP having a specific recognition and adsorptive action on UO2<2+>, and adsorbing the trace uranyl to the surface of the UMIP to form a uranium-containing molecularly imprinted polymer; then accurately detecting the content of the uranium by the heterogeneous photocatalysis resonance fluorescence method. The method has the characteristics of high sensitivity, high specificity, high matrix interference resistance, simplicity, quickness and low cost. The invention also discloses a heterogeneous photocatalysis kinetic analysis and detection device which comprises a photocatalytic reaction system, a low-heat high light source, an air-cooled constant temperature system and an electromagnetic-stirring system.

The invention relates to a complex taking amide-amine as a side chain, and a preparation method and application thereof, belongs to the technical field of magnetic resonance imaging contrast agents, and solves the technical problem about how to provide a metal complex which is high in relaxivity and has a novel skeleton structure, and the preparation method and the application thereof. The structural formula of the complex provided by the invention is shown in a formula I or a formula II, wherein R1, R2, R3 and R4 are all substituent groups and are respectively hydrogen, hydroxyl, amino, carboxyl or alkyl; Mn<+> is a paramagnetic ion of a transition metal or a lanthanide-series metal. The complex which is applied as a contrast agent is low in toxicity; the toxicity of the complex which isrepresented by IC50 is 2.1 mmol / L; the relaxivity reaches 18.57 Mm<-1>s<-1>, and is about three times that of nuclear magnetic resonance contrast agent in clinical use; the complex has a fluorescenceeffect, has strong fluorescence when the complex is excited at 328 nm, and has a potential advantage of serving as a magnetic resonance-fluorescence dual functional contrast agent.