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Application of sodium pyruvate in preparation of drug for relieving high-chlorine acidosis

A technology of sodium pyruvate and acidosis, applied in the field of medicine, can solve the problems of hypercapnia, metabolic acidosis that sodium lactate is not suitable for, intracellular acidosis and the like

Active Publication Date: 2014-06-04
ACADEMY OF MILITARY MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, sodium bicarbonate is the most commonly used clinically. However, studies have shown that infusion of sodium bicarbonate can cause side effects such as hypercapnia, intracellular acidosis, and increased sodium load; sodium lactate is not suitable for hypoxia, liver function damage, etc. Treatment of metabolic acidosis caused by
Many types of alkaline agents have their application limitations, so an ideal alkaline agent that can relieve hyperchloric acidosis and is non-toxic and has no side effects is a problem that needs to be broken through in this field

Method used

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  • Application of sodium pyruvate in preparation of drug for relieving high-chlorine acidosis
  • Application of sodium pyruvate in preparation of drug for relieving high-chlorine acidosis
  • Application of sodium pyruvate in preparation of drug for relieving high-chlorine acidosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment 1, establish the animal model of hyperchloric acidosis induced by ammonium chloride

[0026] Experimental animals: Clean grade Wistar rats, male, 6-7 weeks old, weighing 210g-230g, purchased from Weitong Lihua. They were kept in isolation for 24 hours, fed special feed, drank tap water, and were allowed to eat and drink freely.

[0027]Ammonium chloride (containing 0.5% sucrose) solution: experimental grade, prepared with 0.5% sucrose solution, ready for use.

[0028] Animal model establishment: Rats were fed 0.28M ammonium chloride (containing 0.5% sucrose) solution as daily water, free to eat and drink, and fed for six consecutive days. On the sixth day, blood was taken from the orbit to measure the pH value, and the pH value was less than 7.28. It shows that the model of hyperchloric acidosis was established successfully. The reason why ammonium chloride induces this animal model is that ammonium chloride is metabolized and decomposed into ammonia and hy...

Embodiment 2

[0029] Embodiment 2, the use and effect analysis of sodium pyruvate in the above-mentioned hyperchloric acidosis model

[0030] Sodium pyruvate: pharmaceutical grade, soluble in medical sterile water for injection, ready-to-use.

[0031] Administration method: the rats with hyperchloric acidosis were randomly divided into five groups, and three doses of sodium pyruvate (SP 1 、SP 2 、SP 3 ) group and control group were sodium bicarbonate solution (SB) group and normal saline (NS) group, and the tail vein injection (2mL / K g ), so that the final doses of each group were: SP 1 Group 2mmol / Kg, SP 2 Group 4mmol / Kg, SP 3 Group 6mmol / Kg, SB group 2mmol / Kg, NS group 2mmol / Kg, respectively at 15min, 30min, 60min, 120min, 240min after injection, blood was taken from the orbit for blood gas analysis.

[0032] 1. The effect of sodium pyruvate on blood pH, base excess (Base Excess, BE) value and bicarbonate concentration (cHCO 3 - )Impact

[0033] For pH changes before and after mod...

Embodiment 3

[0046] Embodiment 3, prepare the medicine-injection of alleviating hyperchloric acidosis with sodium pyruvate

[0047] The active ingredient of the drug in this example is sodium pyruvate, and the administration method is a small-volume intravenous injection of high-concentration sodium pyruvate injection, which is different from the application of sodium pyruvate in hemorrhagic shock resuscitation fluid and ischemia-reperfusion injury. Large volume infusion for a long time. This medicine is available as an injection and a powder for injection.

[0048] Drug use:

[0049] Method 1: directly dissolve pharmaceutical grade sodium pyruvate powder in medical sterile water for injection to form an injection, wherein the concentration of sodium pyruvate is 110.4-331.2 mg / mL.

[0050]Method 2: Take 2-10 parts (mass parts) of sodium pyruvate powder, and the rest are sterile excipients (such as mannitol, glycine or alanine, etc.), a total of 10 parts (mass parts), mix the two Mix to ...

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Abstract

The invention discloses a new application of sodium pyruvate, namely an application in preparation of a drug for reliving high-chlorine acidosis. Sodium pyruvate is taken as an active component to prepare the drug for reliving the high-chlorine acidosis, and the drug can be used for regulating the pH value of the blood to be normal and regulating the concentration of sodium ions, potassium ions and calcium ions in the blood so that the aim of reliving the high-chlorine acidosis is fulfilled. The drug disclosed by the invention has the following advantages: (1) the drug is obvious in curative effect and becomes effective rapidly; (2) the drug is free of toxic and side effects and high in safety; (3) sodium pyruvate is low in price; (4) the drug is convenient to carry and take.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the application of sodium pyruvate in the preparation of medicines for alleviating hyperchloric acidosis. Background technique [0002] Metabolic acidosis is the most common acid-base balance disorder, and it is a common clinical complication, and it is called the "triangle of death" together with hypotension and coagulation disorders. It is the extracellular fluid H + increase or HCO 3 - loss due to primary HCO 3 - Decreased (<21mmol / L) and decreased pH (<7.35) are characteristic. In the clinical judgment of metabolic acidosis, it can be divided into high AG type according to different anion gap (AG) values, including lactic acidosis, ketoacidosis, metabolic acidosis caused by drugs or poisons, and renal tubular acidosis. Acidosis; and normal AG-type metabolic acidosis, mainly hyperchloremic metabolic acidosis, referred to as hyperchloric acidosis. Clinically, hyperchloric a...

Claims

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Application Information

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IPC IPC(8): A61K31/19A61P7/08
Inventor 周虹赵莲王瑛杨晶陈赣赵敬湘王波尤国兴尹玉静刘庆军李鹏龙
Owner ACADEMY OF MILITARY MEDICAL SCI
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