Fluorocarbon surfactant and preparation method thereof
A technology of fluorocarbon surfactants and active agents, which is applied in the field of fluorocarbon surfactants and their preparation, and can solve the problems of application limitations and low surface activity of branched chain products.
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Embodiment 1
[0070] Embodiment 1: the synthesis of fluorine-containing intermediate organic acid compound 3
[0071]
[0072] 2.14g of p-bromomethylbenzoic acid, 0.61g of DMAP and 4.12g of DCC were sequentially added into a 100mL jacketed reaction tube. After three times of ventilation, 50mL of anhydrous dichloromethane was added in an ice-water bath, and stirred for a while. Excess methanol was added to the system, and the system was moved to room temperature for reaction after the drop was completed, and the reaction was monitored by TLC. After 5 hours the reaction was complete. System filtration, filtrate successively with KHSO 4 solution, deionized water and saturated brine. The organic phase was dried over anhydrous sodium sulfate, filtered, and the solvent was removed. Finally, the mixture was passed through a silica gel column with an eluent of EA:PE=1:20 to obtain 1.942g of compound 1.
[0073] 1 HNMR (CDCl 3 ,300MHz): δ(ppm)3.92(s,CH 3 ,3H),4.50(s,CH 2 ,2H),7.44-7.48(d,...
Embodiment 2
[0079]Example 2: Synthesis of anionic fluorocarbon surfactants containing branched fluorocarbon chains
[0080]
[0081] 3.6 g of compound 3 was dissolved in 20 mL of tetrahydrofuran, and lithium hydroxide aqueous solution was slowly added dropwise until the system pH=7-8. After dropping, the mixed system was spin-dried to obtain a viscous solid. The solid was washed and filtered with acetone, the filter cake was dissolved with methanol, and the solvent was removed to obtain 3.1 g of white powdery anionic fluorocarbon surfactant.
[0082] 1 HNMR (CD 3 OD,300MHz):δ(ppm)3.71(s,CH 2 ,2H),7.30-7.37(d,J=8.4Hz,Ar-H,2H),7.86-7.93(d,J=8.4Hz,Ar-H,2H); 19 FNMR (CD 3 OD,282MHz,):δ(ppm)-63.68~-63.90(m,6F),-81.98~-82.14(t,3F),-106.90~-107.20(m,2F),-124.05~-124.40(m ,2F). 13 CNMR (CD 3 OD,100MHz,):δ(ppm)33.32,110~127,130.12,132.18,134.28,139.15,174.80;LRMS(EI):454,437.Anal.CalcdforC 14 h 6 f 13 LiO 2 :Li,1.51.Found:Li,1.48.
Embodiment 3
[0083] Example 3: Synthesis of quaternary ammonium salt cationic fluorocarbon surfactants containing branched fluorocarbon chains
[0084]
[0085] Add 5 g of compound 3, 0.675 g of DMAP and 4.2 g of EDCI in sequence in a 100 mL jacketed reaction tube,
[0086] After pumping and exchanging air three times, add 50 mL of dichloromethane under an ice-water bath, and stir for a while. Add excess N,N-dimethylethylenediamine to the system, and after the drop is complete, the system is moved to room temperature for reaction. The reaction was monitored by TLC, and the reaction was completed after 5 hours.
[0087] The system was washed successively with deionized water and saturated brine. The organic phase was dried over anhydrous sodium sulfate, filtered, and the solvent was removed. Finally, the mixture was passed through a silica gel column with dichloromethane:methanol:triethylamine=20:1:a small amount of eluent to obtain 5.126g of compound 7.
[0088] 1 HNMR (DMSO-d 6 ,...
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