Compound glycyrrhizin tablet and preparation method thereof

A glycyrrhizin tablet and the technology of glycyrrhizin, which are applied in the field of compound glycyrrhizin tablet and its preparation, can solve the problems of poor medication compliance of patients, inconvenient use and carrying, and reduced therapeutic effect.

Inactive Publication Date: 2014-06-11
BEIJING INCREASEPHARM CORP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the compound glycyrrhizinate injection is mainly on the market. The existing problems are that it is inconvenient to use and carry, and the patient’s medication compliance is poor. It is difficult for chronic patients, especially hepatitis patients, to adhere to long-term injection medication, which leads to a decrease in the therapeutic effect.

Method used

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  • Compound glycyrrhizin tablet and preparation method thereof
  • Compound glycyrrhizin tablet and preparation method thereof
  • Compound glycyrrhizin tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064]

[0065] The preparation method is:

[0066] (1) Glycyrrhizin, glycine, and DL-methionine are pulverized, passed through an 80-mesh sieve, and set aside; lactose, calcium carbonate, microcrystalline cellulose, and sodium carboxymethyl starch are passed through an 80-mesh sieve, set aside;

[0067] (2) Weigh an appropriate amount of povidone-K30, add 75% ethanol, place and soak until completely dissolved, and prepare a 6% povidone-K30 ethanol solution for later use;

[0068] (3) Mix glycyrrhizin, glycine, DL-methionine, lactose, calcium carbonate, microcrystalline cellulose, and 50% sodium carboxymethyl starch in a container for 30 minutes, then add 6% povidone-K30 ethanol The solution is made into a soft material;

[0069] (4) Granulate through a 20-mesh sieve, dry at 55°C, pass through a 18-mesh sieve for granulation, add magnesium stearate and 50% sodium carboxymethyl starch, mix well, compress into tablets, and set aside;

[0070] (5) Dissolve 15g of medicinal f...

Embodiment 2

[0072]

[0073] The preparation method is:

[0074] (1) Glycyrrhizin, glycine, and DL-methionine are pulverized, passed through an 80-mesh sieve, and set aside; lactose, calcium carbonate, microcrystalline cellulose, and sodium carboxymethyl starch are passed through an 80-mesh sieve, set aside;

[0075] (2) Weigh an appropriate amount of povidone-K30, add 75% ethanol, place and soak until completely dissolved, and prepare a 6% povidone-K30 ethanol solution for later use;

[0076] (3) Mix glycyrrhizin, glycine, DL-methionine, lactose, calcium carbonate, microcrystalline cellulose, and 50% sodium carboxymethyl starch in a container for 30 minutes, then add 6% povidone-K30 ethanol The solution is made into a soft material;

[0077] (4) Granulate through a 20-mesh sieve, dry at 55°C, pass through a 18-mesh sieve for granulation, add magnesium stearate and 50% sodium carboxymethyl starch, mix well, compress into tablets, and set aside;

[0078] (5) Dissolve 15g of medicinal f...

Embodiment 3

[0080]

[0081] The preparation method is:

[0082] (1) Glycyrrhizin, glycine, and DL-methionine are pulverized, passed through an 80-mesh sieve, and set aside; lactose, calcium carbonate, microcrystalline cellulose, and sodium carboxymethyl starch are passed through an 80-mesh sieve, set aside;

[0083] (2) Weigh an appropriate amount of povidone-K30, add 75% ethanol, place and soak until completely dissolved, and prepare a 6% povidone-K30 ethanol solution for later use;

[0084] (3) Mix glycyrrhizin, glycine, DL-methionine, lactose, calcium carbonate, microcrystalline cellulose, and 50% sodium carboxymethyl starch in a container for 30 minutes, then add 6% povidone-K30 ethanol The solution is made into a soft material;

[0085] (4) Granulate through a 20-mesh sieve, dry at 55°C, pass through a 18-mesh sieve for granulation, add magnesium stearate and 50% sodium carboxymethyl starch, mix well, compress into tablets, and set aside;

[0086] (5) Dissolve 15g of medicinal f...

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PUM

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Abstract

The invention belongs to the field of medicines, and provides a compound glycyrrhizin tablet and a preparation method thereof. The compound glycyrrhizin tablet is composed of the following raw materials in parts by weight: 10-50 parts of glycyrrhizin, 10-50 parts of glycine, 10-50 parts of DL-methionine, 30-90 parts of a diluent, 1-20 parts of a disintegrating agent and 0.5-5 parts of a lubricant. The provided compound glycyrrhizin tablet has the advantages of good absorption, beautiful appearance, convenience in administration and carrying around, suitability for long-term administration, simple preparation method, industrial production applicability, and the like.

Description

technical field [0001] The invention relates to a compound glycyrrhizin tablet and a preparation method thereof, belonging to the technical field of oral solid preparations. Background technique [0002] Compound Glycyrrhizin was first widely used in Japan as a standard treatment drug for chronic hepatitis. As early as 1958, Yuuo Yamamoto of Japan applied it to treat patients with chronic hepatitis B, and believed that it had a significant effect on improving transaminase. In 1986, Japanese scholar Kunihiko Hino and others applied compound glycyrrhizin to conduct clinical research on chronic hepatitis B. The results confirmed that more than 90% of patients had improved liver function, and 75% had improved liver tissue morphology. Chronic hepatitis B is one of the common diseases in our country, which poses a great threat to human health. So far, there are not many drugs with definite curative effects. In 2002, Hiromitsu Kumata reported the long-term curative effect of comp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704A61K31/198A61K9/20A61P1/16
Inventor 谭剑平张卫华张永丽
Owner BEIJING INCREASEPHARM CORP LTD
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