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Method for preparing polyethylene glycol network hydrogel

A polyethylene glycol and hydrogel technology, which is used in the field of preparing high-strength polymer networks, can solve the problems of being unable to withstand such a large extrusion impact, and achieve the effects of uniform length distribution and simple operation.

Inactive Publication Date: 2014-06-18
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The fracture energy of conventional hydrogels is about 10 -1 -100J / m -2 , much smaller than vascular tissue (10 2 -10 3 J / m -2 ) and rubber (~10 3 J / m -2 ), the development and application of hydrogels in bionic organs, especially bionic devices with membrane functions, are limited due to the inability to withstand such a large extrusion impact.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] a) Synthesis of azido compounds: Accurately weigh 10 g of polyethylene glycol (M n =1000) was dissolved in 50ml of anhydrous dichloromethane, ice-bathed, and the temperature of the system was lowered to 0°C. After stirring for 3 hours, freshly distilled thionyl chloride (2ml) was weighed and dissolved in 20ml of anhydrous dichloromethane. Slowly drop the thionyl chloride and dichloromethane solution into the polyethylene glycol dichloromethane solution for about 20 minutes at 0°C using a constant-pressure floor liquid funnel. Add 0.2ml neopyridine to the system. Slowly warm up to room temperature, and react for 24 hours under magnetic stirring. After the reaction was completed, the pyridine hydrochloride generated during the system reaction was filtered off, and dichloromethane and excess thionyl chloride were removed by distillation under reduced pressure. The product obtained is precipitated in a large amount of ether, and filtered to obtain polyethylene glycol (M ...

Embodiment 2

[0034] The basic process is the same as in Example 1, the difference is that:

[0035] In step 1), the azide-terminated polyethylene glycol (M n =1000) is 0.15g (0.15mmol), 0.48g (0.024mmol) polyalkyne polyethylene glycol derivative (M n =20000), ultrasonically oscillate at 50°C until completely dissolved, add catalyst-grade cuprous chloride (1.25mg, 0.125mmol), ligand N, N, N', N'', N''-pentamethyl Diethylenetriamine ligand (1.25mmol).

[0036] In step 2), the reaction temperature is 50° C., and the reaction time is 4 hours to form a polymer gel network compound.

[0037] The rest are completely consistent with Example 1.

Embodiment 3

[0039] The basic process is the same as in Example 1, the difference is that:

[0040] In step 1), the azide-terminated polyethylene glycol (M n =1000) is 0.15g (0.15mmol), 0.72g (0.036mmol) polyalkyne polyethylene glycol derivative (M n =20000), ultrasonically oscillate at 50°C until completely dissolved, add catalyst-grade cuprous chloride (1.25mg, 0.125mmol), ligand N, N, N', N'', N''-pentamethyl Diethylenetriamine ligand (1.25mmol).

[0041] In step 2), the reaction temperature is 70° C., and the reaction time is 3 hours to form a polymer gel network compound.

[0042] The rest are completely consistent with Example 1.

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PUM

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Abstract

The invention discloses a method for preparing polyethylene glycol network hydrogel. A polyethylene glycol derivative containing three or more multi-terminal alkynyls and a polyethylene glycol derivative at least containing two terminal overlapped nitrogenous bases are subjected to click reaction, so that the polyethylene glycol network hydrogel is generated. According to the method disclosed by the invention, the position and the number of polymer chain join points are controlled by utilizing amino-epoxy polymerization reaction; then, a required design type polymer network structure is obtained by utilizing click chemical reaction. The method disclosed by the invention is simple for operation, moderate in condition and rapid in reaction; the polymer network prepared by using the method disclosed by the invention has the advantages of being degradable, good in biocompatibility, regular in structure, high in mechanical strength and the like.

Description

technical field [0001] The invention belongs to the field of polymer synthesis methods, and relates to a method for preparing a high-strength polymer network by using click chemistry and amine-epoxy polymerization reaction. Background technique [0002] The polymer gel network structure, especially hydrogel, has a high degree of similarity to human tissue, biocompatibility and high permeability to nutrients and metabolites. In recent years, it has achieved great development in the fields of drug controlled release, material separation, tissue engineering scaffolds, light-adjusting materials, and medical transplant organs. Hydrogel is a three-dimensional network structure of hydrophilic polymers cross-linked, which can quickly absorb and retain most of the water and is insoluble in water. Some small molecular substances can move in the gap of the polymer three-dimensional network, similar to the biomembrane in the organism for the transmission of information and substances. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G81/00C08G65/00
Inventor 付国东钱珊珊姚芳
Owner SOUTHEAST UNIV
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