Calcium phosphate biofilm layer and its pulse electrochemical modification method

A biofilm layer, electrochemical technology, applied in electrolytic inorganic material coating and other directions, can solve the problems of low binding force between calcium and phosphorus salt film layer and metal substrate, difficult to achieve industrial application, etc., to improve comprehensive biological performance, morphology and size Controllable and stable effects

Active Publication Date: 2016-04-06
BEIJING NATON TECH GRP CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] When the calcium phosphate film is prepared on the surface of the metal substrate by the electrochemical deposition method, the binding force between the calcium phosphate film and the metal substrate is low, making it difficult to realize industrial application

Method used

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  • Calcium phosphate biofilm layer and its pulse electrochemical modification method
  • Calcium phosphate biofilm layer and its pulse electrochemical modification method
  • Calcium phosphate biofilm layer and its pulse electrochemical modification method

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Embodiment Construction

[0028] (1) Example of changing Vn:

[0029] In the electrochemical modification method of this embodiment, the effect of Vn on the microstructure of OCP is mainly observed by changing the value of Vn, which specifically includes the following steps: pretreating the implant and putting the implant into a dilute acid solution Vibrate in the medium for 90 seconds, ultrasonically clean in deionized water for 30 seconds, take it out and dry for later use; prepare the electrolyte, the electrolyte concentration is 0.042mol / LCa(NO 3 ) 2 With a concentration of 0.028mol / LNH 4 H 2 PO 4 The pH value of the electrolyte is 4.2; electrochemical deposition is carried out in the electrolyte at a heating temperature of 80℃, the pretreated implant is used as the cathode, and the platinum electrode is used as the anode. Deposition. Among them, V'is -1.1V, T'is 20 seconds; Vn is -2.7V, -2.5V, -2.0V, -1.5V respectively, keep Tn for 15 seconds; potential V1 is -2.4V, keep T1 as 30 seconds; potential ...

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Abstract

The invention provides a calcium and phosphate salt biofilm layer and an electrochemistry modification method thereof. The electrochemistry modification method comprises: carrying out an acid etching treatment, wherein an implant covered with a plasma-coated calcium and phosphate salt biofilm layer is placed into a dilute acid solution, shocking is performed for 1-2 min, ultrasonic cleaning is performed for 1-50 seconds in deionized water, and the obtained implant is taken out and is subjected to air-drying so as to be spare; preparing an electrolyte, wherein the electrolyte is a mixed aqueous solution comprising Ca(NO3)2 with a concentration of 0.001-0.5 mol / L and NH4H2PO4 with a concentration of 0.001-0.5 mol / L, the pH value of the electrolyte is 3-7, and deposition is performed in the electrolyte with a temperature of 50-100 DEG C; and carrying out electrochemical deposition, wherein the time T' is maintained under an electric potential V', the time Tn is maintained under an electric potential Vn, the time T1 is maintained under an electric potential V1, the time T2 is maintained under an electric potential V2, the absolute value of the V' is greater than the open circuit potential, Vn is more than V2, V2 is more than V1, and the sum of the Tn, the T1 and the T2 is 60-180 seconds. The calcium and phosphate salt biofilm layer modified through the method has high bonding strength with the substrate, and has high biological activity.

Description

Technical field [0001] The invention relates to an electrochemical deposition method, in particular to a calcium phosphate salt biofilm layer and a pulse electrochemical modification method thereof. Background technique [0002] Calcium phosphates, including hydroxyapatite (HA), octacalcium phosphate (OCP, HA precursor), etc. are the main inorganic components of human bones and teeth, and have good biocompatibility. The chemical composition and structure of calcium phosphate salt are similar to that of human bone, making it an ideal replacement membrane for human bone. However, due to the brittleness and low strength of calcium phosphate salt, its direct application is restricted. It is usually necessary to coat calcium phosphate salts on the surface of metal alloys with excellent mechanical properties to form a metal / calcium phosphate salt composite film layer, which can maintain the high strength properties of the metal film layer and have the good biological properties of cal...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C25D9/08C25D5/18
Inventor 林昌健林理文段红平王琴琴杨云
Owner BEIJING NATON TECH GRP CO LTD
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