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Stellera chameajasme extract enteric-coated tablet

A technology of Ruixiang lupus poison and extract, which is applied in the directions of drug combinations, plant raw materials, plant/algae/fungus/moss components, etc., can solve the problems of preparations with large side effects, insoluble in water, difficult to prepare preparations, etc.

Inactive Publication Date: 2014-07-02
NANTONG CAMBRIDGE OLEIN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] The existing Rhizoma chamaejasma preparations include chamaejasma injection, chamaejasma solution (external use), chamaejasma ointment, etc. The main active ingredient is ethanol extract or water extract. Due to the simple extraction process, it contains a large number of mixed ingredients, causing side effects of the preparation Large, poor preparation stability, poor curative effect
[0014] Using high-purity extracts, some are difficult to make suitable preparations, some have poor stability, some are difficult to dissolve in water, and have low bioavailability, etc.

Method used

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  • Stellera chameajasme extract enteric-coated tablet
  • Stellera chameajasme extract enteric-coated tablet
  • Stellera chameajasme extract enteric-coated tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0077] Preparation of Daphne chamaejasme extract 1:

[0078] A Daphne chamaejasme extract is characterized in that it is prepared by the following method:

[0079] Step 1. After crushing 1kg of Rhizoma chamaejasma, add 10L of acetone:ethanol=2:1(v:v) mixed solution, heat and reflux for 1 hour, filter out the extract, and add 10L of acetone:ethanol=2:1( v: the mixed solution of v), heated to reflux for 1 hour, filtered out the extract, and combined the filtrate to obtain the extract;

[0080] Step 2, recover the solvent from the combined extract under reduced pressure, concentrate and dry to obtain 85g of dry extract, take 2kg of HPD100 macroporous resin, mix with the dry extract and mix the sample; first, use ethanol:ethyl acetate=1: 1 (v:v) 5L was used as mobile phase for elution, and then 95% ethanol (v:v) 5L was used as mobile phase for elution to obtain an eluent. After recovering ethanol from the eluent, it was concentrated and dried to obtain a 15g sample;

[0081] Ste...

Embodiment 2

[0085] Tablet preparation

[0086] The extract obtained in Example 1 is used as a pharmaceutical active ingredient, added to a pharmaceutical carrier, and prepared according to the conventional technology of pharmacy, such as the following preparation method:

[0087] 10mg of extract 1, 200mg of starch, 100mg of powdered sugar, appropriate amount of magnesium stearate, using starch paste as a binder, mixing, granulating, air-drying, sizing, and tableting to obtain tablets.

[0088] Tablet stability test:

[0089] 10) 0mg of extract 1 and the tablet prepared by the above method were placed in a 40°C incubator, and observed after 3 months, the appearance and color did not change in any way.

Embodiment 3

[0091] Preparation of sugar-coated tablets

[0092] The extract obtained in Example 1 is used as a pharmaceutical active ingredient, added to a pharmaceutical carrier, and prepared according to the conventional technology of pharmacy, such as the following preparation method:

[0093]10mg of extract 1, 200mg of starch, 100mg of powdered sugar, appropriate amount of magnesium stearate, using starch paste as a binder, mixing, granulating, air-drying, sizing, tableting, to obtain tablets, and coating with syrup to obtain sugar coating piece.

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Abstract

The invention relates to a stellera chameajasme extract enteric-coated tablet, wherein the extract is prepared by the following steps: extracting stellera chameajasme by an acetone-ethanol mixed solution; filtering the extract through macroporous resin and carrying out gradient eluting by preparative chromatography, wherein the moving phase A is water and the moving phase B is acetonitrile; and collecting the eluant within 10-15 minutes, and concentrating and drying to obtain the extract.

Description

Technical field: [0001] The invention relates to an anti-tumor traditional Chinese medicine extract, in particular to an anti-tumor extract extracted from the traditional Chinese medicine Daphne chamaejasme and its extraction method and application. Background technique: [0002] Chinese herbal medicine Stellera chamaejasme, English name: RADIX STELLERAE CHAMAEJASMES, is the dry root of Stellera chamaejasme. Excavated in autumn, removed impurities and dried in the sun, the medicinal materials are spindle-shaped, conical or long cylindrical, slightly curved, single or branched, varying in length, with remnants of aboveground stems at the root, brown to tan surface, and twisted Longitudinal grooves and raised lenticels and lateral root scars, and white soft fibers are exposed at the cork peeling off. Light in body, tough in quality, not easy to break, and the section is fibrous. The bark is white, and the wood is light yellow. Slight gas, slightly pungent taste, slightly lo...

Claims

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Application Information

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IPC IPC(8): A61K36/83A61K9/20A61K45/00A61P35/00A61P19/02A61P29/00A61K125/00
Inventor 陆建军钱国栋
Owner NANTONG CAMBRIDGE OLEIN
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