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Medicinal composition for treating pelvic inflammation and application thereof

A composition and technology for pelvic inflammatory disease, applied in the field of pharmaceutical compositions for the treatment of pelvic inflammatory disease, can solve problems such as no compounding, and achieve the effects of reduced daily dosage, low ointment rate, and ease of use

Active Publication Date: 2014-07-02
广州市私域生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there are no related reports on the polysaccharide components of King Kongteng, and there is no report on the compounding of the polysaccharides and total flavonoids.

Method used

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  • Medicinal composition for treating pelvic inflammation and application thereof
  • Medicinal composition for treating pelvic inflammation and application thereof
  • Medicinal composition for treating pelvic inflammation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] The preparation of embodiment 1 King Kong vine polysaccharide extract

[0046] Weigh 100g of the medicinal material of King Kongteng, put it in a 2000ml round bottom flask, add 8 times the amount of 75% ethanol solution, soak overnight, heat and reflux in a water bath for extraction for 2 hours, filter, then add 8 times the amount of 75% ethanol for reflux extraction for 2 hours, filter Then add 8 times the amount of 75% ethanol for reflux extraction for 1 hour, filter, evaporate the residue to dry the solvent, then add 12 times the amount of water, heat and reflux in a water bath at 80°C for 2 hours, filter, and then add 12 times the amount of water , heat and reflux for extraction for 2 hours, repeat again, filter, combine the extracts, centrifuge, and concentrate the supernatant to 250ml under reduced pressure (that is, the concentration of the medicinal solution is 0.4g raw medicinal materials / ml).

[0047] Add 4 times the amount of 95% ethanol to the concentrated s...

Embodiment 2

[0048] The preparation of embodiment 2 King Kong vine polysaccharide extract

[0049]Weigh the medicinal material of King Kongteng, crush it to get 40-80 mesh King Kongteng coarse powder, soak it in deionized water, the mass ratio of King Kongteng coarse powder to deionized water is 1:10-30, add alkali to adjust the pH value to 7-10 , and then extracted under microwave conditions for 3-10min, microwave power 300-800W, filtered to collect the filtrate, and the filter cake was repeatedly extracted for a total of 2-5 times, and the combined filtrate was collected as the extract; the obtained extract was added with acid Adjust the pH value to 2-5, then add 1:2-4 ethyl acetate for extraction, after stirring, stand still and separate layers, keep and collect the lower layer, repeat the extraction with ethyl acetate for 2-5 times, combine all the lower layers, and collect as Retention solution; the retention solution is adjusted to pH 2-3 with trichloroacetic acid solution, lowered t...

Embodiment 3

[0050] The preparation of the total flavonoids extract of embodiment 3 King Kong vines

[0051] Weigh 100g of King Kongteng medicinal material, add 8 times the amount of 75% ethanol to soak overnight, heat and reflux in a water bath for 3 times, the time is 2h, 2h, 1h, combine the extracts, filter, and recover ethanol under reduced pressure until there is no alcohol smell, use pure Dilute the water to 250ml (that is, 0.4g raw medicinal materials / ml); apply D101 macroporous adsorption resin, and the column volume is 250cm 3 , the diameter-to-height ratio is 1:3, first eluted with 2BV of distilled water, then eluted with 3BV of 70% ethanol solution, collected the 70% ethanol eluate, recovered ethanol under reduced pressure at 50°C, and transferred to In an evaporating dish, the solution is evaporated to nearly dryness on a water bath, and then transferred to a 50° C. decompression drying oven for drying. After drying, the total flavonoids extract of King Kongteng can be obtained...

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Abstract

The invention provides a medicinal composition for treating pelvic inflammation, which is a preparation prepared from the following active pharmaceutical ingredients in parts by weight: 10-20 parts of bock greenbrier rhizome total flavone extract and 1-5 parts of bock greenbrier rhizome polysaccharide extract, wherein the polysaccharide content of the bock greenbrier rhizome polysaccharide extract is greater than 20%w / w.The invention also provides a preparation method and application of the extract. The invention also provides a composition for treating pelvic inflammation based on the extract and the like. The research of the invention discovers that after the bock greenbrier rhizome polysaccharide and the bock greenbrier rhizome total flavone extract are used together, the composition has stronger pharmacological activities of resisting inflammation, enhancing immunity, activating blood circulation to dissipate blood stasis and the like, and has better therapeutic action on pelvic inflammation, thus providing a new choice for clinical medication.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating pelvic inflammatory disease and its application. Background technique [0002] With the acceleration of people's life rhythm and the improvement of economic level, people's requirements for quality of life are also getting higher and higher. Some chronic diseases will not directly lead to life-threatening, but due to the long-term lingering and repeated attacks of the disease, it will also bring inconvenience and discomfort to people's lives. Chronic pelvic inflammatory disease is one of these diseases. Chronic pelvic inflammatory disease ( Chronic pelvic inflammatory disease (CPID) refers to the chronic inflammation of female reproductive organs, surrounding connective tissue and pelvic peritoneum. It is one of the most common genital uterine inflammations in women of childbearing age. Chronic pelvic inflammatory disease can lead to infertility, ectopic pregnancy, ectopic pregnancy, o...

Claims

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Application Information

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IPC IPC(8): A61K36/896A61K36/90A61P15/00A61P29/00A61P37/04A61K31/715
Inventor 谭周菊
Owner 广州市私域生物科技有限公司
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