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Preparation method of biological glass mat and application of biological glass mat

A bio-glass, biological technology, applied in medical science, bandages, absorbent pads, etc., can solve the problem of no antibacterial properties, and achieve the effects of reducing pain, preventing wound infection, and excellent antibacterial properties

Inactive Publication Date: 2014-07-02
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, medical dressing products also need to consider the cost of preparation to save care costs for patients, and these products have no obvious antibacterial properties

Method used

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  • Preparation method of biological glass mat and application of biological glass mat
  • Preparation method of biological glass mat and application of biological glass mat
  • Preparation method of biological glass mat and application of biological glass mat

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] 1) Preparation of borate bioglass fiber by blowing method:

[0051] According to the composition of the borate bioglass in Table 1, the oxides, chlorides, carbonates, sulfates and phosphates corresponding to the metal oxides were weighed as glass batch materials. The purity of the raw materials was analytically pure. After grinding, fully Mix to get the original ingredients. Put the original ingredients in a platinum crucible and melt them in a silicon-molybdenum furnace at 1050°C for 0.5h. In the molten state, after the molten glass flows out, use 25°C cold air with an air pressure of 2.0MPa. Blowing, blowing the molten glass into fibers (glass wool) in the state of cotton wool, with a diameter of 50 nanometers to 2 microns, and collecting them for later use.

[0052] Table 1

[0053]

[0054] 2) Preparation of modified chitosan liquid phase:

[0055] Prepare the modified chitosan liquid phase with the following mass percentages of components: 2% acetic acid, 1%...

Embodiment 2

[0060] 1) Preparation of borate bioglass fiber by plugging method

[0061] According to the composition of the borate bioglass in Table 2, the oxides, chlorides, carbonates, sulfates and phosphates corresponding to the metal oxides were weighed as glass batch materials. The purity of the raw materials was analytically pure. After grinding, fully Mix to get the original ingredients. Put the original ingredients in a platinum crucible, melt in a silicon-molybdenum furnace at 1200°C for 4 hours, and flow the molten glass into a platinum crucible with a leaky plate (the hole diameter of the leaky plate is 0.5mm) at the bottom. The glass liquid flows down from the hole of the leak plate to form a glass rod. When it is not completely cooled, it is drawn into a glass filament with a diameter of 30-50 microns by using a wire drawing device (the linear speed of the wire drawing machine is 0.5m / s). Then cut into short fibers (25-30 mm in length) for later use.

[0062] Table 2

[00...

Embodiment 3

[0070] 1) Preparation of borate bioglass fiber by plugging plate method:

[0071] According to the borate bioglass composition of table 3, take by weighing oxide compound, chloride, carbonate, sulfate and phosphate corresponding to metal oxide as glass batch material, the purity of raw material is analytical pure, after grinding, fully Mix to get the original ingredients. Put the original ingredients in a platinum crucible, melt in a silicon-molybdenum furnace at 1250°C for 4 hours, and flow the molten glass into a platinum crucible with a drain plate (the hole diameter of the leak plate is 0.5mm) at the bottom. The glass liquid flows down from the hole of the leak plate to form a glass rod. When it is not completely cooled, it is drawn into a glass filament with a diameter of 10-20 microns by using a wire drawing device (the linear speed of the wire drawing machine is 10m / s). Cut into short fibers (25-30 mm in length) for later use.

[0072] table 3

[0073]

[0074] 2...

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Abstract

The invention discloses a preparation method of a biological glass mat. The preparation method comprises the following steps of processing borate biological glass fibers into chopped fibers which are 5-30 millimeters long, paving the chopped fibers in a mold, adding a modified chitosan liquid phase so that a ratio of the modified chitosan liquid phase to the borate biological glass fibers is 1.0-15ml / g, reacting for 0.5-4 hours and dipping the compound in a diluted acid of which the pH value ranges from 5.5 to 6.5, washing and then heating at 80 DEG C and drying to obtain the porous biological glass mat. The invention also discloses use of the biological glass mat prepared by the method in treating skin injuries. The biological glass mat prepared by the method is a wound skin regeneration / repair biological material which has a series of characteristics such as biocompatibility, bioactivity, biodegradability, biological antibacterial activity, antibacterial agent slow-release property and tissue regeneration property.

Description

technical field [0001] The invention belongs to the technical field of biomaterials, and in particular relates to a preparation method of a bioglass mat that can be used for treating skin wounds and an application of the product. Background technique [0002] Skin trauma has been an unavoidable medical problem in the course of human development. Care of chronic wounds such as decubitus ulcers, which are closely related to this, is a growing hygiene problem as the world population ages and the consequent increase in the prevalence of diabetic and varicose ulcers. Therefore, medical dressings, as a class of important sanitary materials and medical supplies, are more and more concerned by everyone. The world's medical and health fields are also paying more and more attention to the research and development of high-tech medical dressings, and the market demand for new medical dressings will continue to expand. From a global perspective, traditional medical dressings still acco...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/18A61L15/28A61L15/58A61L15/42
Inventor 黄文旵李乐周萘王德平崔旭周杰
Owner TONGJI UNIV
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