Polymer composition and polymer material
A polymer and composition technology, applied in the field of a polymer composition, can solve the problems of action time and efficacy limitation
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Embodiment 1
[0053] Synthesis of Polyvinyl Alcohol Grafted Histidine Derivative "PVA-g-BocHis"
[0054] The structure of polyvinyl alcohol grafted histidine derivative "PVA-g-BocHis" is shown in the following mode (I):
[0055] Formula (I).
[0056] Boc-His-OH (4.48g, 17.57mmol) and DMAP (1.95g, 15.97mmol) were placed in a two-neck bottle equipped with a magnet. The two-necked flask was evacuated for 3 minutes to remove the air inside the flask and then filled with dry nitrogen. Then DMAc (35ml) was added to the two-neck flask and stirred for 10 minutes to suspend the contents evenly. The EDC solid (3.06g, 15.97mmol) was quickly poured into a double-necked flask, and reacted in a 30°C water bath for 3 hours to activate Boc-His-OH. will PVA 10k (Molecular weight 10000) (2.79g, 53.24mmol, 80% hydrolyzed) was added to DMAc (28ml) and stirred at 80°C until completely dissolved to form a PVA solution, and then cooled to 45°C for later use. The activated Boc-His-LG solution (LG=Leaving Gr...
Embodiment 2
[0062] Synthesis of Polyvinyl Vinyl Alcohol Grafted Histidine Derivative "EVOH-g-BocHis"
[0063] The structure of polyethylene vinyl alcohol grafted histidine derivative "EVOH-g-BocHis" is shown in the following way (II):
[0064] Formula (II).
[0065]Boc-His-OH (11.46g, 44.88mmol) and DMAP (4.98g, 40.8mmol) were placed in a two-neck bottle equipped with a magnet. The two-necked flask was evacuated for 3 minutes to remove the air inside the flask and then filled with dry nitrogen. Then DMAc (90ml) was added to the two-neck flask and stirred for 10 minutes to suspend the contents evenly. The EDC solid (7.82g, 40.8mmol) was quickly poured into a double-necked flask, and reacted in a 30°C water bath for 3 hours to activate Boc-His-OH. EVOH (5.84g, 150mmol, 32mol%ethyleneunit) was added into DMAc (58ml) and stirred at 80°C until completely dissolved to form an EVOH solution, and then cooled to 45°C for use. The activated Boc-His-LG solution (LG=Leaving Group (leaving group...
Embodiment 3
[0070] Synthesis of Hydroxypropylmethylcellulose Grafted Histidine Derivative "HPMC-g-BocHis"
[0071] The structure of the hydroxypropyl methylcellulose grafted histidine derivative "HPMC-g-BocHis" is shown in the following mode (III):
[0072] Formula (III).
[0073] Boc-His-OH (2.92g, 11.44mmol) and DMAP (1.27g, 10.4mmol) were placed in a two-neck bottle equipped with a magnet. The two-necked flask was evacuated for 3 minutes to remove the air inside the flask and then filled with dry nitrogen. Then DMAc (22.9ml) was added to the two-neck flask and stirred for 10 minutes to suspend the contents evenly. The EDC solid (1.99g, 10.4mmol) was quickly poured into a double-necked flask, and reacted in a 30°C water bath for 3 hours to activate Boc-His-OH. HPMC (2.0g, 10.4mmol, Mn120,000, degree of substitution (DS) of methoxy: 1.1-1.6mol, molar degree of substitution of propylene oxide , MS): 0.1-0.3mol) into DMAc (40ml) and stirred at 80°C until completely dissolved to form ...
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