Method for preparing furoic acid by cell catalysis of furfural

A technology for furfural and furoic acid, which is applied in the field of cell catalysis of furfural to prepare furoic acid, can solve the problems of furoic acid product separation or wastewater treatment difficulties, inability to fully meet usage requirements, consumption of metal catalysts, etc., and achieves good practicability and easy industrialization. , The effect of wastewater treatment is simple

Active Publication Date: 2014-07-09
易高卓新节能技术(上海)有限公司
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  • Application Information

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Problems solved by technology

The above-mentioned method has the difficulties of incomplete conversion of furfural, consumption of met

Method used

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  • Method for preparing furoic acid by cell catalysis of furfural

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Experimental program
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Effect test

Embodiment 1

[0021] In a 250mL Erlenmeyer flask with a stopper, add 50mL furfural aqueous solution, the initial concentration of furfural is 6.5g / L, add 10g / L calcium carbonate to control the pH of the reaction system from 4.0 to 7.0, and transfer the shaker flask to a constant temperature shaking culture at 30°C ± 5 bed, adjust the shaking and stirring speed to 220r / min, insert the activated Gluconobacter oxydans to a cell concentration of 1.0 g / L to carry out the cell catalytic reaction.

[0022] The operation method of semi-continuous addition was adopted, adding 6.5 g / L furfural (based on the volume of the reaction solution) every 24 hours, and adding calcium carbonate to control the pH of the reaction system from 4.0 to 7.0. Stop feeding after the 6th day, and add 39g / L furfural in total. Continue to react until the 10th day, stop the reaction, and the reaction process diagram is as follows: figure 1 Shown; in the figure, the abscissa represents the reaction time (d), the main ordin...

Embodiment 2

[0024] In a 3 L mechanically ventilated reaction tank, add 1.5 L of furfural solution to an initial furfural concentration of 7.0 g / L, add 20 g / L of calcium carbonate to adjust the pH of the reaction system to 4.0~7.0, and maintain the temperature of the reaction system at 30°C ± 5. Stirring speed 350~500r / min and ventilation rate 3~5vvm, keep the tank pressure at 0.01~0.02MPa, insert activated Gluconobacter oxydans to a cell concentration of 1.0g / L for cell catalysis.

[0025] The concentration of substrate furfural and product furoic acid in the reaction system is detected in real time. When the concentration of furfural is lower than 2g / L, furfural (purity higher than 97%) is automatically added to the concentration not higher than 10g / L. When adding total consumption to furfural and reaching 40g / L, stop feeding furfural to continue reaction. After reacting to 92 hours, furfural is completely consumed, and product furoic acid concentration reaches 41.5g / L, and termination r...

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Abstract

The invention discloses a method for preparing furoic acid by cell catalysis of furfural. The method comprises the following steps: (1) in an oscillating or stirring ventilated reaction system, inoculating gluconobacter oxydans which is 1.0g/L in cell concentration to implement a reaction by taking furfural liquid which is not more than 10g/L in initial substrate concentration as a reaction matrix; (2) adding furfural to the reaction system in a way of semi-continuously or continuously adding materials in batches, controlling furfural concentration in the reaction system within 10g/L until total amount of the added furfural is 39-40g/L, monitoring and regulating a pH value to be not more than 10g/L in real time; (3) and ending the reaction until the furfural in the reaction system is completely consumed to obtain furoic acid liquid. The method disclosed by the invention is free from a metal catalyst or severe acid and alkali conditions; moreover, the furfural as a substrate is completely consumed and is high in conversion rate; a furoic acid product is high in purity, easy to separate and refine, and wastewater treatment is simple; the concentration of the furoic acid product exceeds 40g/L under the conditions that a consumption rate of the substrate furfural is 100% and the conversion rate of the furoic acid product exceeds 96%.

Description

technical field [0001] The invention relates to the technical field of furoic acid preparation, in particular to a method for preparing furoic acid from furfural by cell catalysis. Background technique [0002] Furoic acid, also known as α-furan carboxylic acid, 2-furan carboxylic acid or furan carboxylic acid, is an intermediate in organic synthesis, which can be converted into esters, acid chlorides, acid anhydrides, amides and other derivatives for the production of 2-methylfuran, Furamide, furoate (salt), plasticizers, thermosetting resins, food industry preservatives, coating additives, spices, and synthetic medicines such as fururonium penicillin and ceftiofur. [0003] The currently reported methods for preparing furoic acid mainly use furfural as raw material, using Cannizzaro reaction, metal catalysis or electrolysis of furfural. For example, Chinese patent application 200910112526.8 adopts "a method for simultaneous preparation of sugar alcohol and furoic acid bas...

Claims

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Application Information

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IPC IPC(8): C12P17/04C12R1/01
Inventor 徐勇瑞切尔·陈
Owner 易高卓新节能技术(上海)有限公司
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