Vitamin A palmitate eye drop, preparation method and use thereof

A technology of palmitate and eye drops, applied in the directions of pharmaceutical formulations, medical preparations without active ingredients, and medical preparations containing active ingredients, etc.

Active Publication Date: 2014-07-16
SHENYANG XINGQI PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it is very difficult to prepare fat-soluble vitamin A palmitate into eye ...

Method used

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  • Vitamin A palmitate eye drop, preparation method and use thereof
  • Vitamin A palmitate eye drop, preparation method and use thereof
  • Vitamin A palmitate eye drop, preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] Embodiment 1: Preparation of Vitamin A Palmitate Eye Drops 1

[0069] 1) Prescription:

[0070]

[0071] 2) Preparation method:

[0072] (1) Add vitamin A palmitate and BHA to medium-chain fatty acid triglycerides, mix and dissolve for later use;

[0073] (2) Soak and dissolve the poloxamer with an appropriate amount of water, and set aside;

[0074] (3) Add ethyl paraben to an appropriate amount of water and heat to dissolve.

[0075] (4) Add the poloxamer soaking solution to the above solution and mix well;

[0076] (5) Add polyethylene glycol to the above solution, heat to dissolve; add sorbitol and glycerin respectively, stir and dissolve, and mix well;

[0077] (6) Add vitamin A palmitate solution to the above solution,

[0078] (7) Add water to the full amount, mix well and filter.

Embodiment 2

[0079] Embodiment 2: Preparation of Vitamin A Palmitate Eye Drops 2

[0080] 1) Prescription:

[0081]

[0082] 2) Preparation method:

[0083] (1) Add vitamin A palmitate and BHA to medium-chain fatty acid triglyceride and stir to dissolve, set aside;

[0084] (2) Add benzalkonium bromide into an appropriate amount of water and stir to dissolve;

[0085] (3) Add Tween-80, glycerin, and sorbitol to the above solution respectively, and stir to dissolve;

[0086] (4) Add vitamin A palmitate solution to the above solution and mix well;

[0087] (5) Add water to the full amount, mix well and filter.

Embodiment 3

[0088] Embodiment 3: Preparation of Vitamin A Palmitate Eye Drops 3

[0089] 1) Prescription:

[0090]

[0091] 2) Preparation method:

[0092] (1) Add vitamin A palmitate and BHT to medium-chain fatty acid triglycerides, mix and dissolve for later use;

[0093] (2) Soak and dissolve the poloxamer with an appropriate amount of water, and set aside;

[0094] (3) Add cetrimonium bromide into an appropriate amount of water and heat to dissolve;

[0095] (4) Add the poloxamer soaking solution to the above solution and mix well;

[0096] (5) Add propylene glycol to the above solution, heat to dissolve; add mannitol and glycerin respectively, stir and dissolve, and mix well; mix well;

[0097] (6) Add vitamin A palmitate solution to the above solution,

[0098] (7) Add water to the full amount, mix well and filter.

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PUM

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Abstract

The invention belongs to the field of pharmaceutical pharmacy, and relates to a vitamin A palmitate eye drop, a preparation method and a use thereof. Specifically the eye drop contains 0.01-0.2% (w/w) of vitamin A palmitate adopted as a main drug, 0.01-5.0% (w/w) of a solubilizing agent and 0.01-10.0% (w/w) of a co-solvent. According to the present invention, the assisted solubilizing manner is adopted so as to solve problems of solubility and stability of vitamin A palmitate in water; and the eye drop is a light yellow transparent solution, has a characteristic of low eye irritation, and is suitable for eyes.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and relates to a vitamin A palmitate eye drop and a preparation method and application thereof. Background technique [0002] Vitamin A palmitate is a vitamin drug with the molecular formula C 36 h 60 o 2 , the molecular weight is 524.5, and the structural formula is as follows: [0003] [0004] Vitamin A, including its palmitate, can significantly increase the number of conjunctival goblet cells, induce the formation of corneal epithelial cell growth factor receptors and glycoprotein synthesis, stimulate the incorporation of glucose and glucosamine into the corneal epithelium, and promote the healing of corneal dry spots and corneal punctate defects , to smooth the rough, granular corneal surface, for dry eye from various causes (e.g. Sjogren's syndrome, neuroparalytic keratitis, exposure keratitis, etc.) and conjunctiva due to lack of tear film protection Or corneal irritation...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/232A61K47/44A61K47/34A61K47/10A61P27/02
Inventor 刘继东杨宇春唐海艾立诚杨强
Owner SHENYANG XINGQI PHARM CO LTD
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