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Chitosan-nano-silver wound dressing and preparation method thereof

A technology of wound dressing and chitosan, which is applied in the field of chitosan-nano silver wound dressing and its preparation, can solve the problems of affecting wound healing, stimulating wound, liquid penetration, etc., and achieve excellent wound repair ability, growth promotion, size uniform effect

Inactive Publication Date: 2014-08-06
WUHAN INSTITUTE OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these dressings are usually exposed to the air. While exchanging gas with the outside world, some unclean liquid may also penetrate into the wound, thereby irritating the wound and affecting wound healing.
This is also a deficiency in the current clinical application of wound dressings.

Method used

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  • Chitosan-nano-silver wound dressing and preparation method thereof
  • Chitosan-nano-silver wound dressing and preparation method thereof
  • Chitosan-nano-silver wound dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Preparation of spongy chitosan: Weigh 0.8g chitosan (deacetylation degree is 70%, viscosity is 100cPa s), dissolve it in 50mL acetic acid solution with a concentration of 0.5wt%, and the obtained shell The polysaccharide acetic acid solution was poured into a glass petri dish and placed in a refrigerator for pre-freezing at -20°C for 12h. Then place it in a vacuum freeze dryer for freeze-drying treatment, wherein the parameters of the freeze dryer are: the cold trap temperature is -40°C, the vacuum degree is 10Pa, and the freezing time is 18 hours. Subsequent soaking treatment with 1.0 mol / L sodium hydroxide solution for 2 hours, and repeated washing with deionized water until neutral spongy chitosan was obtained.

[0039] Preparation of nano-silver sol: Weigh 1.2g polyvinylpyrrolidone (PVP, weight-average molecular weight Mw=55,000), dissolve it in 60mL deionized water, add dropwise 6mL silver nitrate aqueous solution with a concentration of 0.1mol / L, stir for 30 minut...

Embodiment 2

[0047] Preparation of spongy chitosan: Weigh 1.0g chitosan (deacetylation degree is 95%, viscosity is 100cPa s), dissolve in 50mL acetic acid solution with a concentration of 1wt%, and dissolve the obtained chitosan The sugar-acetic acid solution was poured into a glass petri dish and placed in a refrigerator for pre-freezing at -18°C for 12 hours. Then place it in a vacuum freeze dryer for freeze-drying treatment, wherein the parameters of the freeze dryer are: cold trap temperature-55°C, vacuum degree 4Pa, and freezing time of 24 hours. Subsequent soaking treatment with 2.0 mol / L sodium hydroxide solution for 2 hours, and repeated washing with deionized water until neutral spongy chitosan is obtained.

[0048] Preparation of nano-silver sol: Weigh 0.05g polyvinylpyrrolidone (PVP, weight average molecular weight Mw=55,000), dissolve it in 50mL deionized water, add dropwise 2.5mL silver nitrate aqueous solution with a concentration of 0.1mol / L, and stir for 30 minutes Slowly ...

Embodiment 3

[0055] Preparation of spongy chitosan: weigh 1.5g chitosan (deacetylation degree is 100%, viscosity is 200cPa s), dissolve in 50mL acetic acid solution with a concentration of 1.5wt%, and the obtained shell The polysaccharide acetic acid solution was poured into a glass petri dish and placed in a refrigerator for pre-freezing at -22°C for 8 hours. Then place it in a vacuum freeze dryer for freeze-drying treatment, wherein the parameters of the freeze dryer are: cold trap temperature-58°C, vacuum degree 8Pa, and freezing time 16h. Subsequent soaking treatment with 1.2 mol / L ammonia solution for 2 hours, and repeated washing with deionized water until neutral spongy chitosan was obtained.

[0056] Preparation of nano-silver sol: Weigh 0.5g polyvinylpyrrolidone (PVP, weight-average molecular weight Mw=55,000), dissolve it in 45mL deionized water, add dropwise 2.5mL silver nitrate aqueous solution with a concentration of 0.2mol / L, and stir for 30 minutes Slowly add 0.1mol / L sodiu...

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Abstract

The invention provides a chitosan-nano-silver wound dressing which comprises a water absorption antibiosis layer and a hydrophobic layer for gluding a wound, wherein the water absorption antibiosis layer comprises chitosan and nano-silver; according to the water absorption antibiosis layer, spongy chitosan is soaked in sol contained nano-silver, and the nano-silver is uniformly compounded on the spongy chitosan through freeze drying; the other side adopts the hydrophobic layer. A preparation method of the chitosan-nano-silver wound dressing comprises the following steps: (1) preparing chitosan-nano-silver sponge; (2) uniformly spraying an ethanol solution on one surface of the chitosan-nano-silver sponge prepared in step (1), prefreezing under minus 18 DEG C, and then performing freeze drying to obtain the chitosan-nano-silver wound dressing. According to the invention, the chitosan, the nano-silver, fatty acid and other hydrophobic modifiers for preparing the chitosan-nano-silver wound dressing have high biosecurity and have no toxic or side effects on human cells; in addition, the chitosan is of a sponge structure, excellent in softness and high in breathability.

Description

technical field [0001] The invention belongs to the technical field of preparation of medical dressing biological materials, and in particular relates to a chitosan-nanometer silver wound dressing and a preparation method thereof. Background technique [0002] The skin is an important organ of the human body, a natural barrier and a bridge of communication between the body and the outside world. Loss of skin tissue due to burns, trauma, and skin ulcers can lead to wound infection. Currently, one effective method of dealing with skin wounds is the use of wound dressings. [0003] Traditional wound dressings include gauze, absorbent cotton, bandages, etc. However, from a medical point of view, these traditional wound dressings have limited clinical application because they do not have the properties of treating and repairing wounds, nor do they have antibacterial activity. Therefore, new medical dressings that can promote wound healing, have high antibacterial properties an...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/18A61L15/42A61L15/44A61F13/02
Inventor 陈嵘梁冬晖杨浩吕中
Owner WUHAN INSTITUTE OF TECHNOLOGY
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