Method for raising biocompatibility of polyester fiber artificial ligament by graphene modification

A technology of biocompatibility and artificial ligament, applied in medical science, prosthesis, coating, etc., to achieve good repeatability, accelerate bone healing, and improve biocompatibility

Inactive Publication Date: 2014-08-13
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although there are many patents on graphene and artificial ligaments in China, there are still no literature and patent repor...

Method used

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  • Method for raising biocompatibility of polyester fiber artificial ligament by graphene modification
  • Method for raising biocompatibility of polyester fiber artificial ligament by graphene modification

Examples

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preparation example Construction

[0041] A. Preparation of graphene: (1) Copper foil is placed in a CVD reaction furnace. (2) Under the condition of 3kPa, the reaction furnace is heated to 1000°C, with CH4 as the carbon source, H 2 It is a reducing gas, and Ar is an inert gas, which is passed into the reaction furnace. (3) Return to room temperature after reacting for 10 minutes to obtain uniform single-layer graphene grown on copper foil.

[0042] B. Preparation of graphene transfer film: (1) Spin-coat polymethyl methacrylate PMMA (2) on the graphene copper foil prepared on-site at 3000r / min and put the copper foil on a heating plate at 150°C for baking Bake for 15 minutes to solidify the glue. (3) Dissolve the baked copper foil in ammonium sulfate solution for 24 hours to corrode the Cu substrate. (4) After corroding the copper substrate, obtain a PMMA film floating on the surface of the ammonium sulfate solution and adhered with single-layer graphene. (5) Transfer the obtained PMMA film to deionized wat...

Embodiment 1

[0047] This embodiment proceeds according to the following steps:

[0048] 1. First place 10X10cm25μm thick copper foil (99.9%) into a CVD reaction furnace with a diameter of 8cm by crimping. Then, under the Ar gas atmosphere, the temperature was raised to 1000°C under the condition of 3kPa, the Ar gas flow was maintained at 200sccm (1sccm=1mL / min), and the heating rate was 10°C / min; when the copper foil reached the target temperature, H 2 Gas reduction annealing, the flow rate is 65sccm, the Ar gas flow rate and temperature remain unchanged: after 20min, 50sccm methane, 65sccmH 2 After growing with 200sccm Ar gas for 10min, turn off methane and hydrogen, and lower the furnace to room temperature at 10°C / s under Ar gas atmosphere. Obtain uniform single-layer graphene grown on copper foil.

[0049] 2. Spin-coat 7% polymethyl methacrylate PMMA on the graphene copper foil prepared on site at 3000r / min. After spin-coating, place the copper foil on a 150°C heating plate and bake f...

Embodiment 2

[0052] This embodiment proceeds according to the following steps:

[0053] 1. First place 10X10cm25μm thick copper foil (99.9%) into a CVD reaction furnace with a diameter of 8cm by crimping. Then the temperature was raised to 1000°C under normal pressure under the Ar gas atmosphere, the Ar gas flow was maintained at 200 sccm (1 sccm = 1mL / min), and the heating rate was 10°C / min; when the copper foil reached the target temperature, H 2 Gas reduction annealing, the flow rate is 65sccm, the Ar gas flow rate and temperature remain unchanged: after 20min, 50sccm methane, 65sccmH 2 After growing with 200sccm Ar gas for 10min, turn off methane and hydrogen, and lower the furnace to room temperature at 10°C / s under Ar gas atmosphere. Obtain uniform single-layer graphene grown on copper foil.

[0054] 2. Spin-coat 7% polymethyl methacrylate PMMA on the graphene copper foil prepared on site at 3000r / min. After spin-coating, place the copper foil on a 150°C heating plate and bake for 1...

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Abstract

The invention discloses a method for raising biocompatibility of polyester fiber artificial ligament by graphene modification. According to the method, a large area of single-layer graphene which grows by a CVD method is transferred to polyester fiber-woven artificial ligament by a matrix corrosion method so as to raise biocompatibility of the artificial ligament. A graphene coating is applied on the polyester fiber micropore-woven artificial ligament, thus greatly raising biocompatibility of the artificial ligament material, especially cytocompatibility. Adhesion of cells to the surface of the material and propagation of cells are promoted; BMSC is induced to differentiate into osteoblastic cells; and bone tunnel healing during implantation of the artificial ligament into body is accelerated. In addition, the graphene coating hasn't caused adverse effect on porosity, strength and creep resistance of the material. The method provided by the invention is simple to operate and has good repeatability.

Description

technical field [0001] The invention belongs to the technical field of artificial ligaments, and relates to a surface modification technology of polyester fiber artificial ligaments, in particular to a method for graphene modification to improve the biocompatibility of polyester fiber artificial ligaments. Background technique [0002] Anterior cruciate ligament (ACL) injuries are the most common type of joint ligament injury. Because the ACL has the functions of restricting the excessive anterior movement of the tibia, controlling the rotation of the tibia and proprioceptors, its damage can directly cause knee joint instability and functional decline, and then cause meniscus and cartilage degeneration, leading to early-onset osteoarthritis, which seriously affects the knee joint. Patient quality of life. It has become a consensus to repair and reconstruct damaged ligaments by surgical grafting. However, autologous (patellar tendon or hamstring tendon, etc.) transplantatio...

Claims

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Application Information

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IPC IPC(8): A61L27/30A61L27/18A61L27/56A61L27/50
Inventor 韩一生王春辉毕龙张振宇郭建斌燕明郭忠尚
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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