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Etoricoxib gel preparation and preparation method thereof

A gel preparation and etoricoxib technology, applied in the field of etoricoxib gel and preparation thereof, can solve problems such as poor solubility of etoricoxib, achieve stable and reliable preparation quality, simple production process and improved absorption rate Effect

Inactive Publication Date: 2014-08-20
王俊国
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The present invention provides a new etoricoxib gel, which solves the problem of poor solubility of etoricoxib in water by using tromethamine to dissolve etoricoxib, and improves the penetration of etoricoxib to the skin , so that the absorption rate of etoricoxib through the skin is improved, and the curative effect of treating arthritis or rheumatoid arthritis through topical administration is significantly improved, and at the same time, it provides a new route of administration for patients

Method used

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  • Etoricoxib gel preparation and preparation method thereof
  • Etoricoxib gel preparation and preparation method thereof
  • Etoricoxib gel preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028]

[0029]

[0030] Preparation process

[0031] Put the carbomer in purified water with 50% of the total prescription and soak for 24 hours. The tromethamine is dissolved in water with 10% of the total dosage of the prescription for subsequent use. Put etoricoxib in ethanol and stir to disperse evenly, add tromethamine aqueous solution and stir to dissolve until the solution is completely clear, and set aside. Stir and dissolve edetate disodium and the remaining purified water until there are no visible particles, and set aside; filter the swollen carbomer 940 through 120 mesh, and add the prescribed amount of propylene glycol, polyethylene glycol 400, edetate di Sodium solution and etoricoxib solution are added to Carbomer. Stir for 15 minutes; add triethanolamine into the carbomer matrix, stir for 30 minutes, control the pH at 7.3-8.5, stop stirring, fill, pack, and obtain etoricoxib gel.

Embodiment 2

[0033] The etoricoxib raw material is formulated into etoricoxib gel according to the following prescription:

[0034]

[0035]

[0036]Put the carbomer in purified water with 50% of the total prescription and soak for 24 hours. The tromethamine is dissolved in water with 10% of the total dosage of the prescription for subsequent use. Put etoricoxib in ethanol and stir to disperse evenly, add tromethamine aqueous solution and stir to dissolve until the solution is completely clear, and set aside. Stir and dissolve edetate disodium and the remaining purified water until there are no visible particles, and set aside; filter the swollen carbomer 940 through 120 mesh, and add the prescribed amount of propylene glycol, polyethylene glycol 400, edetate di Sodium solution and etoricoxib solution are added to Carbomer. Stir for 15 minutes; add triethanolamine into the carbomer matrix, stir for 30 minutes, control the pH at 7.3-8.5, stop stirring, fill, pack, and obtain etorico...

Embodiment 3

[0038] The etoricoxib raw material is formulated into etoricoxib gel according to the following prescription:

[0039]

[0040] Put the carbomer in purified water with 50% of the total prescription and soak for 24 hours. The tromethamine is dissolved in water with 10% of the total dosage of the prescription for subsequent use. Put etoricoxib in ethanol and stir to disperse evenly, add tromethamine aqueous solution and stir to dissolve until the solution is completely clear, and set aside. Stir and dissolve edetate disodium and the remaining purified water until there are no visible particles, and set aside; filter the swollen carbomer 940 through 120 mesh, and add the prescribed amount of propylene glycol, polyethylene glycol 400, edetate di Sodium solution and etoricoxib solution are added to Carbomer. Stir for 15 minutes; add triethanolamine into the carbomer matrix, stir for 30 minutes, control the pH at 7.3-8.5, stop stirring, fill, pack, and obtain etoricoxib gel.

...

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Abstract

The invention provides an etoricoxib gel preparation and a preparation method thereof. The gel preparation comprises the following components in percentage by weight: 0.3 to 10% of etoricoxib, 0.3 to 25% of carbomer 940, 0.1 to 30% of tromethamine, 1 to 45% of ethyl alcohol, 5 to 50% of propylene glycol, 0.5 to 5% of polyethylene glycol 400, 0.05 to 0.8% of edetate disodium, 1.0 to 10% of triethanolamine, and the balance of pure water. According to the preparation method, tromethamine is used to dissolve etoricoxib so as to solve the problem that etoricoxib is hardly dissolved in water; the skin penetrability of etoricoxib is improved and the transdermal absorption rate of etoricoxib is increased, and local external application of the gel preparation can obviously improve the treatment effect on arthritis or rheumatoid arthritis; simultaneously, a new administration route is provided for patients. The gel preparation is in a form of semi-solid gel with good transdermal absorption effect etoricoxib is completely dissolved and dispersed in the gel preparation, and thereby the pain of the patient can be relieved favorably. The preparation method is simple in process, and the preparation is stable and reliable in quality.

Description

field of invention [0001] The invention relates to a pharmaceutical preparation for treating arthritis and a preparation method thereof, which belongs to the medicine for orthopedic diseases, and in particular to an etoricoxib gel and a preparation method thereof. Background of the invention [0002] Rheumatoid arthritis can occur at any age, mostly in 30-60 years old, 45 years old is the most common, with age, the incidence rate also increases, the incidence rate of women is significantly higher than that of men, the number of people suffering from different degrees of rheumatoid arthritis in my country at present Already close to 200 million people. According to a survey of people aged 15 and above in Shanghai, if the economic burden of disease caused by DALY losses is not included, the annual economic burden of disease caused by arthritis per capita is 74.59 yuan. The economic burden of disease caused by each major type of arthritis is: 778.63 yuan per capita for osteoart...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K31/444A61K47/18A61P29/00A61P19/02
Inventor 王俊国朱金强邓念万伟
Owner 王俊国
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