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Composition for skin containing silicone base

A composition and skin technology, which can be applied in the directions of medical preparations containing active ingredients, medical preparations without active ingredients, skin diseases, etc., can solve the problems of deterioration, increase, and damage to the feeling of touch and use of the composition, etc., To achieve the effect of excellent touch and use, excellent use, and high mixing ratio

Inactive Publication Date: 2014-08-20
MARUHO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to disperse the aqueous solvent into the silicone agent, it is necessary to use a non-silicone thickener (thickener without silicon), but the addition of the thickener deteriorates the touch when the composition is applied to the skin
[0006] In addition, since the composition of Patent Document 1 contains only about 70% by weight of the silicone agent, the amount of other components increases, so there is a problem that the characteristics of the silicone agent, that is, the excellent touch and feeling of use are impaired.

Method used

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  • Composition for skin containing silicone base
  • Composition for skin containing silicone base

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] [Example 1] Preparation and evaluation of drug-dispersed composition

[0060] Compositions having the compositions shown in Tables 1 and 2 were prepared in the following procedure. In addition, as active ingredients, steroid (betamethasone butyrate propionate) and active VD 3 (Maxacalcitol). In addition, as a mixture of the silicone elastomer (b1) and the cyclic volatile methylsiloxane [decamethylcyclopentasiloxane] (b2), ST-Elastomer 10 (silicone from DOW CORNING) was used. Elastomer: decamethylcyclopentasiloxane = 12:88 [weight ratio]), and as the linear type dimethyl polysiloxane (b3), Q7-9120 Silicone Fluid 100CST of Dow Corning Corporation was used.

[0061] Preparation method of drug dispersion type composition

[0062] (1) Weigh the mixture of (b1) and (b2) in a suitable container.

[0063] (2) Add (b3) to (1) and mix.

[0064] (3) The active ingredient was added to (2), and stirred with a homomixer (6000 rpm, 5 minutes) at room temperature to disperse it. ...

Embodiment 2

[0072] [Example 2] Preparation of drug-dissolving composition

[0073] Compositions having the compositions shown in Tables 3 and 4 were prepared in the following procedure. In addition, the mixture of active ingredient, silicone elastomer (b1) and cyclic volatile methylsiloxane [decamethylcyclopentasiloxane] (b2), linear dimethylpolysiloxane (b3 ) The same thing as in Example 1 was used, and Nikkol DES-SP of Nikko Kagaku was used as diethyl sebacate.

[0074] Preparation method of drug-dissolving composition

[0075] (1) Weigh the mixture of (b1) and (b2) in a suitable container.

[0076] (2) Add (b3) to (1) and mix.

[0077] (3) The active ingredient previously dissolved in the oily solvent was added to (2), and it stirred and mixed with the homomixer (6000 rpm, 5 minutes) at room temperature.

[0078]The composition prepared in the above-mentioned manner is a white translucent gel-liquid composition. When each composition was observed with a microscope, no crystal disp...

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Abstract

The present invention addresses the problem of providing a composition for the skin, which has excellent texture and feeling of use. The present invention provides an anhydrous composition for the skin, which is characterized in that: (A) 80% by weight or more of the composition is composed of a silicone base; (B) the silicone base contains (b1) a silicone elastomer, (b2) a cyclic volatile methyl siloxane that has 3-6 silicon atoms and (b3) a linear dimethyl polysiloxane and / or a linear methylphenyl polysiloxane; (C) the composition contains an active component that is present in a dispersed or dissolved state; and (D) the composition does not contain a non-silicone thickener.

Description

technical field [0001] The present invention relates to dermatological compositions comprising a silicone matrix. More specifically, it relates to an anhydrous skin composition containing a silicone matrix and a main drug dispersed or dissolved therein. Background technique [0002] Compositions in various dosage forms have been conventionally used as external preparations for use on the skin. For skin compositions, high potency of the main ingredient (active ingredient), that is, excellent stability and transdermal absorbability of the main ingredient are required, but as other important characteristics, touch when applied to the skin, Excellent usability. In particular, an ointment is a dosage form with excellent coverage, but it is accompanied by a sticky feeling, so a smooth touch (skin feel) that suppresses the sticky feeling is required. [0003] As a composition excellent in feeling of touch and usability, for example, Patent Document 1 discloses a composition comp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/34A61K8/89A61K8/891A61K9/06A61K9/08A61K47/24A61P17/00A61Q19/00
CPCA61K2800/31A61K2800/5922A61K8/891A61K9/0014A61K9/06A61K47/34A61K31/075A61Q19/00A61K31/573A61K8/585A61P17/00
Inventor 堀泽荣次郎伊原干人
Owner MARUHO
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