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Manufacturing method of antituberculous slow release artificial bone scaffold

An artificial bone and anti-tuberculosis technology, applied in the field of biomedicine, can solve problems such as poor effect of artificial bone scaffolds, achieve good osteogenic performance, promote rehabilitation, and inhibit regeneration.

Inactive Publication Date: 2014-08-27
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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Problems solved by technology

[0006] The technical problem to be solved by the present invention is to provide a preparation method of an anti-tuberculosis slow-release artificial bone support, and the preparation method of this anti-tuberculosis slow-release artificial bone support will solve the problem of treating tuberculosis with the artificial bone support in the prior art Technical Issues That Don't Work Well

Method used

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Embodiment 1

[0023] 1. Preparation of Mesoporous Bioactive Glass

[0024] 4g triblock copolymer surfactant P123 (polyethylene oxide-polypropylene oxide-polyethylene oxide triblock copolymer write specific chemical name) was dissolved in 60ml ethanol, and 6.7g was added under stirring condition Tetraethyl orthosilicate, 1.4g calcium nitrate tetrahydrate, and 0.73g triethyl phosphate were stirred and reacted at room temperature for one day, then transferred into a watch glass and volatilized and dried in a fume hood for 1 week, and the obtained dry glue was calcined at 650 degrees for 6 Hours to remove P123, to obtain mesoporous bioactive glass (MBG).

[0025] 2. Preparation of Carboxyl- and Methyl-Modified Mesoporous Bioactive Glasses

[0026] Add 0.5g of MBG powder into 50ml of pre-dried toluene, heat to 80°C and reflux. Add 0.1g of silane coupling agent methyltriethoxysilane to it to prepare methyl-modified MBG solution, after the solution fully reacts for 16h, centrifuge to separate MB...

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Abstract

A manufacturing method of an antituberculous slow release artificial bone scaffold comprises the step for manufacturing mesoporous biological activity glass, the step for manufacturing methyl modified mesoporous biological activity glass, the step for manufacturing carboxyl modified mesoporous biological activity glass, the step for carrying antituberculosis drug rifampicin, the step for carrying antituberculosis drug isoniazide, the step for allocating printing slurry and the step for 3D printing manufacturing of the artificial bone scaffold. The method includes the specific steps that CAD software is used for manufacturing a cylinder of a 3D model first, the mixed slurry is used as printing ink, the printing ink is filled into a print needle cylindrical silo, a plastic needle is used for printing in an X-Y direction alternating mode according to the 3D model, and finally the novel antituberculous slow release artificial bone scaffold is obtained. By the adoption of the method, the manufactured antituberculous bone scaffold can continuously release antituberculosis drugs in a human body, meanwhile, good osteogenesis performance can be achieved, and an obvious function can be achieved on treatment and repair of bone tuberculosis focus defects.

Description

[0001] Technical field: [0002] The invention belongs to the field of biomedicine, and in particular relates to an artificial bone support, in particular to a preparation method of an anti-tuberculosis slow-release artificial bone support. Background technique: [0003] Epidemiological surveys in recent years have shown that the incidence of tuberculosis in the world is on the rise. According to survey estimates, there are about 20 million tuberculosis patients in the world, and the number of tuberculosis patients in my country ranks second in the world, with about 5 million tuberculosis patients. Among all tuberculosis patients, patients suffering from bone and joint tuberculosis account for about 1% to 2%. With the increasing prevalence of AIDS and the increasing use of various immunosuppressants, the number of patients is also increasing year by year. Bone and joint tuberculosis is the most common type of extrapulmonary tuberculosis, and its incidence has shown a ...

Claims

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Application Information

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IPC IPC(8): A61L27/54A61L27/10A61L27/18
Inventor 李坤叶晓健余将明
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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