A liraglutide in-situ gel preparation and a preparing method thereof

A technology of in-situ gel and liraglutide, which is applied in the fields of pharmaceutical formulation, aerosol delivery, peptide/protein composition, etc., can solve problems such as poor patient compliance, short drug action time, peak and valley phenomenon of blood drug concentration, etc. , achieve pain relief, clear skin and connective tissue structure, and reduce the number of medications

Inactive Publication Date: 2014-10-01
HYBIO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Since diabetes is a chronic disease that requires long-term treatment, the existing liraglutide preparation is a common injection, which is prone to peak and valley phenomena in blood concentration, and the drug has a short action time, requiri

Method used

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  • A liraglutide in-situ gel preparation and a preparing method thereof
  • A liraglutide in-situ gel preparation and a preparing method thereof
  • A liraglutide in-situ gel preparation and a preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Example 1 Preparation of liraglutide in situ gel preparation

[0055] Weigh 25g of PLGA (Mn=10000, LA:GA=75:25), add it into 100mL NMP solvent, mix well, and prepare a polymer solution, then add 7.0g of liraglutide raw material, heat and stir at constant temperature (temperature 30 ℃, 200rpm) for 30 minutes to form a translucent drug-loaded sol system, which is sterilized by γ-ray radiation.

Embodiment 2

[0056] Example 2 Preparation of liraglutide in situ gel preparation

[0057] Weigh 30g of PLGA (Mn=15000, LA:GA=50:50), add it into 100mL NMP solvent, mix well, and prepare a polymer solution, then add 7.5g of liraglutide raw material, heat and stir at constant temperature (temperature 30 ℃, 250rpm) for 30 minutes to form a translucent drug-loaded sol system, which is sterilized by γ-ray radiation.

Embodiment 3

[0058] Example 3 Preparation of liraglutide in situ gel preparation

[0059] Weigh 25g PLGA (Mn=20000, LA:GA=50:50) and 4g poloxamer 407, dissolve in 110mL NMP, mix well, and prepare a polymer solution, then add 6.5g liraglutide, keep the temperature Heat and stir (temperature 30°C, 150rpm) for 35 minutes to form a translucent drug-loaded sol system, which is sterilized by gamma-ray radiation.

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Abstract

The invention relates to the field of medicine preparations, in particular, the invention relates to a liraglutide in-situ gel preparation and a preparing method thereof. The liraglutide in-situ gel preparation comprises liraglutide, an in-situ gel material and an organic solvent. Based on g/g/mL, the mass volume ratio of the liraglutide, the in-situ gel material and the organic solvent is (0.5-1.5):(2-6):(14-30). The liraglutide in-situ gel preparation has a function of sustained release and avoids peak and valley phenomena of plasma concentrations. The medicine function time is long and the number of times of taking the medicine is reduced, thus largely alleviating pain of patients and improving compliance of patients. The liraglutide in-situ gel preparation is nonirritant to skin and connective tissues. The preparing method is simple, suitable for large-scale production, high in medicine loading capacity and low in cost.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a liraglutide in-situ gel preparation and a preparation method thereof. Background technique [0002] Due to many factors such as the improvement of living standards, changes in dietary structure, increasingly tense pace of life, and a less active and more sedentary lifestyle, the incidence of diabetes worldwide is increasing rapidly. Diabetes has become the third serious threat after tumors and cardiovascular diseases. Chronic diseases of human health. At present, there are more than 120 million people with diabetes in the world, and the number of patients in China ranks second in the world. The incidence of diabetes in China is as high as 9.6%. Diabetes will remain a serious public health problem in China in the next 50 years. Diabetes is divided into gestational diabetes, specific diabetes, type I diabetes and type II diabetes. Among them, type II diabetes, also kn...

Claims

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Application Information

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IPC IPC(8): A61K38/26A61K9/06A61K47/38A61K47/36A61K47/34A61P3/10
Inventor 颜携国陶安进马亚平袁建成
Owner HYBIO PHARMA
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