A liraglutide in-situ gel preparation and a preparing method thereof

Abstract

The invention relates to the field of medicine preparations, in particular, the invention relates to a liraglutide in-situ gel preparation and a preparing method thereof. The liraglutide in-situ gel preparation comprises liraglutide, an in-situ gel material and an organic solvent. Based on g / g / mL, the mass volume ratio of the liraglutide, the in-situ gel material and the organic solvent is (0.5-1.5):(2-6):(14-30). The liraglutide in-situ gel preparation has a function of sustained release and avoids peak and valley phenomena of plasma concentrations. The medicine function time is long and the number of times of taking the medicine is reduced, thus largely alleviating pain of patients and improving compliance of patients. The liraglutide in-situ gel preparation is nonirritant to skin and connective tissues. The preparing method is simple, suitable for large-scale production, high in medicine loading capacity and low in cost.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a liraglutide in-situ gel preparation and a preparation method thereof. Background technique [0002] Due to many factors such as the improvement of living standards, changes in dietary structure, increasingly tense pace of life, and a less active and more sedentary lifestyle, the incidence of diabetes worldwide is increasing rapidly. Diabetes has become the third serious threat after tumors and cardiovascular diseases. Chronic diseases of human health. At present, there are more than 120 million people with diabetes in the world, and the number of patients in China ranks second in the world. The incidence of diabetes in China is as high as 9.6%. Diabetes will remain a serious public health problem in China in the next 50 years. Diabetes is divided into gestational diabetes, specific diabetes, type I diabetes and type II diabetes. Among them, type II diabetes, also kn...

AI Technical Summary

Problems solved by technology

[0008] Since diabetes is a chronic disease that requires long-term treatment, the existing liraglutide preparation is a common injection, which is prone to peak and valley phenomena in blood concentration, and the drug has a short action time, requiring daily injections. It caused a lot of pain and inconvenience, resulting in poor patient compliance, and there is an urgent need for a long-acting and sustained-release liraglutide preparation to relieve patients’ pain and improve patient compliance.

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