Medical composition for treating bile related diseases, and preparation method and application thereof

The technology of a composition and medicine is applied in the pharmaceutical composition for the treatment of gallbladder-related diseases, the botanical composition for the treatment of digestive system diseases, and the preparation field, which can solve the problems of patient death and the like, and achieve pain relief, inhibition of normal bile secretion, The effect of suppressing abnormal bile secretion

Active Publication Date: 2014-10-15
SICHUAN RES INST OF NATURE DRUGS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Improper handling can cause death of the patient (Qin Changchun, Wu Xinmin, Report of Six Cases of Hypersecretion of Bile, Journal of Clinical Surgery, September 2001, Volume 9, No. 5, Pages 338-339). Hypersecretion of bile generally has no clinical symptoms. But it can cause serious consequences when doing external drainage of bile

Method used

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  • Medical composition for treating bile related diseases, and preparation method and application thereof
  • Medical composition for treating bile related diseases, and preparation method and application thereof
  • Medical composition for treating bile related diseases, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0078] The steps of the preparation method of the oral liquid of the present invention are as follows:

[0079] Take 4.0-2.0 parts by weight of Phyllanthus emblica, 3.2-0.5 parts by weight of Myrobalan, and 2.8-0.4 parts by weight of Myrobalan, which are cleanly selected, free of impurities, insects, and mildew, and are used after passing the inspection.

[0080] Mix the above components, add 6-20 times the weight of water and decoct 2 times for 1 hour each time, filter, combine the filtrate, and place in a vacuum concentration tank at 60°C and 0.02mpa under reduced pressure and concentrate to a relative density of 1.10- 1.25(20℃) extract, add appropriate amount of agar and honey, mix well, place at 4°C for 48 hours, filter, add appropriate amount of flavoring to the filtrate, mix well, add appropriate amount of Pengrun soil, mix well, place at 4°C for 48 hours, filter repeatedly , The filtrate is sent to the 100,000 clean-level automatic bottling workshop for filling, and each bot...

Embodiment 2

[0100] The steps of the preparation process of the capsule of the present invention are as follows:

[0101] Take 4.0-2.0 parts by weight of Phyllanthus emblica, 3.2-0.5 parts by weight of Myrobalan, and 2.8-0.4 parts by weight of Myrobalan, which are cleanly selected, free of impurities, insects, and mildew, and are used after passing the inspection.

[0102] Mix the above components, add 6-20 times the amount of water and decoct 2 times for 1 hour each time, filter, combine the filtrate, and place in a vacuum concentration tank at 60°C and 0.02mpa under reduced pressure and concentrate to a relative density of 1.10- Add ethanol to the extract at 1.25 (20℃) until the ethanol content reaches 70%, mix well, let stand overnight, filter, and after the filtrate recovers ethanol, place it in a vacuum concentration tank, and concentrate at 60℃ and 0.02mpa under reduced pressure. Thick paste with a density of 1.28-1.40 (20°C). Take starch, dextrin, and powdered sugar (7:1:1) as auxiliary...

Embodiment 3

[0115] Example 3. Study on the pharmacological effectiveness of the combination of the present invention

[0116] Experiment 1. The effect of the combination of the present invention on normal bile secretion:

[0117] The guinea pigs were randomly grouped according to their body weight, 10 in each group. Before the experiment, the animals were fasted for 12 hours without water, and the animals in each group were anesthetized by intraperitoneal injection of 20% uracil 1mL / 100g.bw, and then the common bile duct was inserted into the silicone tube. After the operation was completed, the bile was collected and the bile volume was measured to observe the stability of bile secretion. The test substance is based on the clinical dose. The equivalent dose of guinea pigs converted to body surface area is 1.17g crude drug / kg. Take 0.52g crude drug / mL of SLJ oral liquid and administer 1mL / 100g, which is 5.2g crude drug / kg. After the bile secretion stabilized (90 minutes), the test substance...

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Abstract

The invention discloses a medical composition for treating bile related diseases, and a preparation method and application thereof. The medical composition comprises emblic leafflower fruits, medicine terminalia fruits and belleric terminalia fruits, and is prepared into pills or oral liquids through the steps of mixing, decocting in water, compressing and the like. The medical composition shows obvious effect on inhibiting normal biliation in animal experiments, can remarkably inhibit excessive abnormal biliation, alters dynamic parameters in a biliary tract, lowers internal pressure of a gallbladder and a biliary duct, reduces resistance of Oddi sphincter muscle, reduces stimulation of bile on a wound surface of a biliary surgery and harms of bile on gastrointestinal mucosa, achieves the effects of relieving pain and promoting functional restoration, is suitable for the treatment of biliary dyskinesia which includes the biliary dyskinesia after a gallbladder resection and the biliary dyskinesia outside the chole, can remarkably relieve recurrent right upper quadrant pain, right upper quadrant pressing pain, continuous epigastric burning sensation, substernal pain and other associated symptoms, such as eructation, sour regurgitation, nausea vomit, anorexia and emaciation.

Description

Technical field [0001] The invention relates to a pharmaceutical composition, a preparation method and its use, in particular to a botanical composition for the treatment of digestive system diseases, a preparation method and its use, in particular to a pharmaceutical composition for the treatment of bile-related diseases, a preparation method and its use. Background technique [0002] Biliary dyskinesia (Biliary dyskinesia) refers to the symptoms of suspected biliary dysfunction, but through various imaging examinations, no organic changes in any part of the biliary system, such as gallstones, inflammation, tumors, are found [James Toouli Current Treatment Options in Gastroenterology 09 / 2002; 5(4):285-291. DOI: 10.1007 / s11938-002-0051-9]. The process of bile discharge is completed by the ingenious movement regulation of the gallbladder, duct and Oddi's sphincter. The occurrence of biliary dyskinesia is a disorder of normal movement regulation. Its clinical manifestations are v...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/47A61P1/16A61P1/04
Inventor 李星炜莫太刚刘小军樊三虎兰明邓雪梅
Owner SICHUAN RES INST OF NATURE DRUGS
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