Unlock instant, AI-driven research and patent intelligence for your innovation.

Avermectin auxiliary agent and preparation method thereof

Active Publication Date: 2014-11-05
威尔(福建)生物有限公司
View PDF3 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After it forms a drug film in the environment, sunlight will accelerate its decomposition, resulting in a half-life of only 4h
It can be seen that abamectin is easily oxidized and decomposed when exposed to light, resulting in poor photostability and short duration of field use, which virtually increases the frequency of farmers' application and the cost of pest control, thus making it difficult to promote in the field
At present, the antioxidants used to improve the photostability of abamectin mainly include BHT, BHA, PG, TBHQ and ultraviolet absorbers UV-9, NBC, etc., but these monomers or compounds are not enough to fundamentally Solve the overall use effect of Abamectin

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Avermectin auxiliary agent and preparation method thereof
  • Avermectin auxiliary agent and preparation method thereof
  • Avermectin auxiliary agent and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0031] (1) The preparation method of abamectin auxiliary agent of the present invention, because 6-heptynol raw material is easy to obtain, has high boiling point, the character that lipophilic group is moderate, chooses 6-heptynol as initiator, in Under certain conditions, ethylene oxide and propylene oxide are introduced, and the prepared polymeric reactant has a main chain, which has a strong emulsifying property and can be "anchored" on the pesticide particles;

[0032] (2) The abamectin adjuvant prepared by the preparation method of the abamectin adjuvant of the present invention has extremely strong permeability, can accelerate the original drug to pass through the stratum corneum of the target, improve the pesticide absorption rate, and has ultra-high The permeability of the target stratum corneum;

[0033] (3) It has super photolysis resistance, and can also increase the efficacy of avermectin through synergistic effects (the different effects of different components a...

Embodiment 1

[0044] Step 1: Add 1mol initiator 6-heptynol into the reactor, and at the same time add potassium hydroxide with a weight ratio of 3‰ as a catalyst, stir, heat up to 60-80°C and vacuumize to remove moisture, and then heat up to 80°C -100°C, slowly add 15mol ethylene oxide in batches, heat preservation and aging for 30min after adding, then add 15mol propylene oxide in batches, heat preservation and aging for 30min after the reaction is completed, adjust the pH value to 6-7 after cooling down, and obtain 6- Heptynol polyether;

[0045] Step 2: Feed the obtained 6-heptynol polyether and fulvic acid into the reactor at a molar ratio of 3:1, and use p-toluenesulfonic acid with a weight ratio of 3‰ as a catalyst to reflux through the solvent toluene method, nitrogen is introduced for protection, the esterification temperature is controlled at 120-135°C, and the preferred temperature is 125-130°C to obtain 6-heptynol polyether and esterified products; the solvent toluene reflux meth...

Embodiment 2

[0049] Step 1: Add 1mol initiator 6-heptynol into the reaction kettle, and at the same time add potassium hydroxide catalyst with a weight ratio of 3‰, stir, heat up to 60-80°C and vacuumize to remove moisture, then heat up to 80-100°C ℃, slowly add 10mol ethylene oxide in batches, keep warm for 30 minutes after adding, then add 20mol propylene oxide in batches, keep warm for 30 minutes after the reaction is completed, and adjust the pH value to 6-7 after cooling down;

[0050] Step 2: Feed the obtained 6-heptynol polyether and humic acid into the reactor at a molar ratio of 6:1, and in the presence of the catalyst p-toluenesulfonic acid with a weight ratio of 3‰, through the solvent toluene reflux method, Under nitrogen protection, the esterification temperature is controlled at 120-135°C, preferably at 125-130°C, to obtain 6-heptynol polyether ester;

[0051] Step 3: At the same time, in the reaction kettle equipped with agitator, thermometer and condenser, 10mol of the 6-he...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to an avermectin auxiliary agent, which is characterized by having a structural formula A or B, wherein M equals to 5-20, n equals to 10-30, and m / n equals to 1-2; M represents humic acid or hydrogen; R1 and R2 represent phenol or hydrogen; if R1 represents phenol, then R2 is hydrogen; and if R1 represents hydrogen, R2 represents phenol. The invention also relates to the preparation of the abamectin auxiliary agent. The avermectin auxiliary agent provided by the invention has the strong emulsifying property, so as to anchor on pesticide particles, also has super high target cuticle permeability and superstrong photolysis resistance, can enhance the efficacy of avermectin through synergistic effect; and compared with a compound antioxidant, the avermectin auxiliary agent has the advantages of rain washing resistance.

Description

technical field [0001] The invention relates to the field of pesticide adjuvants, in particular to an abamectin adjuvant with anti-photolysis and high penetration and a preparation method. Background technique [0002] Avermectins are a class of sixteen-membered macrocyclic lactone compounds with insecticidal, acaricidal and nematicidal activities. They have the characteristics of wide insecticidal spectrum, high efficiency, safety, low residue and good environmental compatibility. . In the late 1980s, my country began to introduce abamectin strains. At present, there are quite a few registered abamectin products, but their promotion area in Daejeon is still small. Apart from its relatively high price, the reason why abamectin is limited in field promotion has a lot to do with the rapid decomposition of abamectin when exposed to light. The photodegradation half-life of abamectin in water is 12h, and under simulated sunlight, the half-life of abamectin is less than 10h. A...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A01N25/22A01N25/30A01N61/00A01P7/04A01P7/02C08G81/00A01N43/90
Inventor 倪素美
Owner 威尔(福建)生物有限公司