Preparation method and application of laponite bioceramics

A bioceramic and hectorite technology, applied in medical science, prosthesis, etc., to achieve the effect of simple operation, good biocompatibility, and low cost of LAP

Inactive Publication Date: 2014-11-26
上海交通大学附属第一人民医院 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] However, up to now, there is no literature report on the deviceization of LAP nanomaterials by the tablet method, and the preparation of LAP bioceramics for the repair of bone tissue damage.

Method used

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  • Preparation method and application of laponite bioceramics
  • Preparation method and application of laponite bioceramics
  • Preparation method and application of laponite bioceramics

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preparation example Construction

[0049] The preparation method of laponite bioceramics provided by the present invention includes:

[0050] Step 1. Press synthetic laponite powder into tablets to obtain laponite tablets; the amount of synthetic laponite powder per laponite tablet is 0.3-0.6g; the compression pressure is 8-15 MPa; The tableting process is to compress the tablet by uniaxial compression in the mold (uniaxial compression refers to the method of pressing powder along an axial direction).

[0051] Step 2, sintering the obtained laponite flakes to obtain a laponite bioceramic; the sintering temperature is 600-800 ℃, and the sintering time is 2-6 h. The sintering process is carried out in a muffle furnace. During the process of heating up to the sintering temperature during sintering, the heating rate is 2-15 ℃ / min.

[0052] The method for preparing laponite bioceramics provided by the present invention also includes using scanning electron microscopy (SEM), X-ray diffraction (XRD), contact angle test, an...

Embodiment 1

[0075] Take 0.45 g of LAP powder, place it in a mold with a diameter of 14 mm, and compress tablets under a pressure of 10 MPa by a uniaxial compression method to obtain LAP tablets. Four LAP sheets were placed in a muffle furnace and sintered under the conditions shown in Table 1 to prepare LAP bioceramics, which were recorded as samples 2-5.

[0076] The diameter of the sample before and after sintering was measured with a micrometer, and the calculated diameter shrinkage rate is shown in Table 1. The density of all samples was measured using Archimedes' principle and divided by the original LAP powder to get the relative density change (see Table 1). The hydrophilicity of all samples was measured by contact angle. 1 μL of distilled water was dropped on the surface of the sample, and then measured with a contact angle meter. The results are shown in Table 1. The morphological changes of the LAP sheet prepared by the present invention are observed by SEM, as shown in Fig. 1. Th...

Embodiment 2

[0080] Take the LAP tablets and LAP bioceramics prepared in Example 1 respectively to test their XRD patterns (see attached figure 2 ). XRD test results show that at a lower sintering temperature (600 o C) There is no crystalline phase transformation before and after LAP sintering. And at higher sintering temperature (800 o C) The characteristic diffraction peaks of sodium mica and enstatite appear in the spectrum, indicating that the resulting LAP bioceramic contains crystal components such as LAP, sodium mica and enstatite.

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Abstract

The invention discloses a preparation method and an application of laponite (LAP) bioceramics. The method comprises a first step of tabletting LAP powder in a mold through a uniaxial pressing method to obtain LAP sheets; and a second step of sintering the LAP sheets in a muffle furnace to obtain the LAP bioceramics. The preparation method and application provided by the invention are simple in process; products are easily available; cost of LAP is relatively low; the prepared LAP bioceramics have good blood compatibility and good capacity for accelerating bone healing, and have wide application prospects in the fields of tissue engineering scaffold materials, particularly the field of bone damage repair.

Description

Technical field [0001] The invention relates to a preparation method and use of bioceramics, in particular to a preparation method of laponite bioceramics and its use in bone injury repair. Background technique [0002] With the rapid growth and aging of our population, the number of cases of bone injury caused by various traumas, bone tumors or joint surgery has also increased rapidly. The repair of these bone injuries is a huge clinical problem and has become a key factor affecting the quality of patient treatment. In clinical practice, autologous bone transplantation is the most mature technology and standard for bone defect treatment. However, autologous bone transplantation requires surgical removal of bone, and the available bone tissue is limited. At the same time, there are complications such as pain and infection at the bone removal site. With the advancement of technology, although allogeneic bone transplantation can solve the above shortcomings, there are also problem...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C04B35/16C04B35/622A61L27/10A61L27/50
Inventor 赵庆华李吉鹏张永兴王传舜王世革史向阳
Owner 上海交通大学附属第一人民医院
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