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Method for grinding viscous medicine with zirconium beads

A grinding method and viscous technology, which is applied in the field of pharmaceutical grinding and dispersion, can solve the problems of affecting the grinding quality and drug stability, accelerating the wear and breaking of beads, and unsatisfactory grinding fineness, so as to be beneficial to human body absorption and reduce production costs. Low, the effect of ensuring drug safety

Active Publication Date: 2014-12-03
SHANGHAI YANAN PHARM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the commonly used drug grinding methods include high-pressure impact, homogeneous cutting, etc.; but when applied to viscous drugs, the grinding fineness is not ideal, and it also affects the stability of the drug.
When grinding with grinding beads, when the drug slurry is too thick, it is easy to cause accumulation of grinding beads and direct contact with the wear parts of the grinding machine to accelerate the wear and breakage of the beads, which in turn affects the grinding quality and the stability of the drug.

Method used

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  • Method for grinding viscous medicine with zirconium beads
  • Method for grinding viscous medicine with zirconium beads
  • Method for grinding viscous medicine with zirconium beads

Examples

Experimental program
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Effect test

Embodiment 1

[0032] This embodiment relates to the preparation of zirconium beads (yttria-stabilized zirconia microspheres with a diameter of 1.0 to 2.0 mm) used in the viscous drug zirconium bead grinding method; the method specifically includes the following steps:

[0033] a. Press Y 2 o 3 Content is the ratio of 3mol%, configuration ZrO(NO 3 ) 2 .2H 2 O and Y (NO 3 ) 3 .6H 2 O mixed solution is the mother liquor; take ZrO(NO 3 ) 2 The concentrations are 0.25mol / L, 0.75mol / L, 1.5mol / L respectively;

[0034] b. At 80°C, add chitosan and pectin, adjust the pH value to 1, age and polymerize to form a gel, and dry to obtain a precursor;

[0035] ZrO(NO 3 ) 2 The infrared spectrum of the corresponding precursor when the concentration is 0.75mol / L is as follows figure 1 As shown, the stretching vibration peak of O-H in the gel is around the wave number 3410 / cm, and the stretching vibration peak of -COOH at 1630 / cm is enhanced compared with chitosan and pectin, and at 1422cm -1 Co...

Embodiment 2

[0049] This embodiment relates to a method for grinding viscous drug zirconium beads, specifically using the yttria-stabilized zirconia microbeads with a diameter of 2mm prepared in Example 1 for grinding, specifically: putting the zirconium beads into a rotating disk In the stainless steel container, after adding the viscous drug, start the rotating disc to drive the zirconium beads to roll up and down for grinding, the grinding speed is 800-2800 rpm; the grinding time is adjusted according to the viscosity of the viscous drug.

[0050] Taking nifedipine as an example, the grinding experiment was carried out. Nifedipine belongs to poorly soluble drugs, limited by its solubility characteristics, it has the problems of low dissolution rate and low bioavailability. In order to improve the bioavailability, the particle size is reduced by grinding, the effective dissolution area of ​​the drug is increased, and the dissolution rate of the drug is increased. Grinding efficiency and...

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Abstract

The invention discloses a method for grinding a viscous medicine with zirconium beads. The method comprises the following steps: preparing circular zirconium beads with the diameter of 1.0mm-2.0mm, putting the zirconium beads into a stainless steel container with a rotating disc, adding a viscous medicine, and starting the rotating disc to drive the zirconium beads to perform up-down turning grinding at the grinding rotating speed of 800-2800 revolutions per minute, wherein the zirconium beads are yttrium oxide stabilized zirconia micro beads prepared by rolling and sintering Y2O3-ZrO2 powder. With the adoption of a corresponding technology combined with the high-hardness zirconium beads, the problem that a viscous medicine cannot be dispersed during grinding is solved, so that the medicine is superfine and stable, and the safety of the medicine is ensured.

Description

technical field [0001] The invention relates to medicine grinding and dispersing technology, in particular to a viscous medicine zirconium bead grinding method. Background technique [0002] Grinding media can be divided into glass beads, ceramic beads (including zirconia silicate beads, zirconia beads, alumina beads) etc. according to different materials. Due to the difference in chemical composition and manufacturing process, the crystal structure of the grinding beads is determined. The dense crystal structure ensures the high strength, high wear resistance and low oil absorption of the beads. The different percentages of various ingredients determine the specific gravity of the grinding beads. The high specific gravity provides a guarantee for high grinding efficiency; the chemical composition of the grinding beads will have a certain impact on the performance of the slurry during the grinding process. Therefore, in addition to considering In addition to low wear rates,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B02C17/10C04B35/48C04B35/622
Inventor 王学亮
Owner SHANGHAI YANAN PHARM
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