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Chitosan-iodine composite biomedical membrane and preparation method thereof

A biomedical and shell iodine technology, which is applied in the field of medical materials, can solve the problems such as the introduction of biological dressings that have not yet been discovered, and achieve superior hemostatic function, protect the wound surface, and improve the effect of the microenvironment

Active Publication Date: 2014-12-10
ZHEJIANG SANCHUANG BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, many manufacturers at home and abroad have launched silver-containing dressings, but no functional biological dressings containing shell iodine have been found.

Method used

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  • Chitosan-iodine composite biomedical membrane and preparation method thereof
  • Chitosan-iodine composite biomedical membrane and preparation method thereof
  • Chitosan-iodine composite biomedical membrane and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0070] 1. The chitosan polyvinyl alcohol foam layer is composed of gelatin, chitosan and polyvinyl alcohol, and is prepared according to the following steps:

[0071] Ⅰ. Prepare a 1.0wt% gelatin solution, and heat it in a water bath at 50°C until it is completely dissolved;

[0072] Ⅱ. Add 1.0wt% polyvinyl alcohol to the above solution, and heat in a water bath at 90°C until completely dissolved;

[0073] Ⅲ. Add 0.6wt% chitosan, heat until completely dissolved

[0074] Ⅳ. Add 1.0wt% foaming agent and stir for 1 hour at a speed above 1000r / min;

[0075] Ⅴ. Add 0.8wt% glycerol and mix thoroughly;

[0076] Ⅵ. Add 0.01wt% glutaraldehyde and mix thoroughly;

[0077] Ⅶ. Gained chitosan polyvinyl alcohol foam is spread flat on a tetrafluoroethylene plate, and vacuum freeze-dried;

[0078] Ⅷ. Vacuum freeze-drying to obtain a molded foam, wash off unreacted glutaraldehyde, vacuum freeze-drying again, and obtain chitosan polyvinyl alcohol foam after drying;

[0079] Shell iodine, p...

Embodiment 2

[0095] 1. The chitosan polyvinyl alcohol foam layer is made up of gelatin, chitosan and polyvinyl alcohol, and is prepared as follows:

[0096] Ⅰ. Prepare a 3.0wt% gelatin solution, and heat it in a water bath at 50°C until it is completely dissolved;

[0097] Ⅱ. Add 5.0wt% polyvinyl alcohol to the above solution, and heat in a water bath at 90°C until completely dissolved;

[0098] Ⅲ. Add 0.8wt% chitosan, heat until completely dissolved

[0099] Ⅳ. Add 3.0wt% foaming agent and stir for 1 hour at a speed above 1000r / min;

[0100] Ⅴ. Add 2.0wt% glycerin and mix well;

[0101] Ⅵ. Add 0.1wt% glutaraldehyde and mix well;

[0102] Ⅶ. spread the obtained chitosan polyvinyl alcohol foam 0.3mm thick on the tetrafluoroethylene plate, vacuum freeze-drying;

[0103] Ⅷ. Vacuum freeze-drying to obtain a molded foam, wash off unreacted glutaraldehyde, vacuum freeze-drying again, and obtain chitosan polyvinyl alcohol foam after drying;

[0104] Shell iodine, polyvinyl alcohol and carbox...

Embodiment 3

[0120] The shell iodine composite biomedical film (i.e. shell iodine polyvinyl alcohol-polyvinyl alcohol-chitosan polyvinyl alcohol foam-polyglutamic acid reticular gel composite material) will be obtained, and the experimental group of 30 cases of the General Hospital of Chengdu Military Command The clinical trial with 30 cases of control groups proves that the shell iodine composite biomedical film with the shell iodine polyvinyl alcohol layer and the gel layer as the matrix provided by the present invention is used for wound dressings such as trauma wounds, surgical wounds, and burn wounds. Compared with the product prepared with application number 201310010441.5, it has more functions of protecting wound surface, absorbing exudate, stopping bleeding, preventing and controlling wound infection, and promoting wound healing, etc. It is safe and effective in clinical use.

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Abstract

The invention provides a chitosan-iodine composite biomedical membrane. The chitosan-iodine composite biomedical membrane is formed by compounding a chitosan-iodine polyvinyl alcohol layer, a polyvinyl alcohol layer, a chitosan polyvinyl alcohol foam layer and a hydrophilic reticular polyglutamic acid gel layer; the chitosan polyvinyl alcohol foam layer is compounded between the polyvinyl alcohol layer and the hydrophilic reticular polyglutamic acid gel layer. The four layers take different effects, wherein the chitosan-iodine polyvinyl alcohol layer has the effects of resisting bacteria, moisturizing and promoting healing, the polyvinyl alcohol layer has the effects of moisturizing and promoting healing, the chitosan polyvinyl alcohol foam layer has the effects of dewatering, absorbing seepage and moisturizing, and the hydrophilic reticular polyglutamic acid gel layer has the effects of stopping bleeding, adsorbing wounds and absorbing seepage and transferring the seepage to the chitosan polyvinyl alcohol foam layer. The chitosan-iodine composite biomedical membrane is characterized in that the chitosan-iodine polyvinyl alcohol layer and the polyvinyl alcohol layer are heated by microwave so that a polar medium can be heated quickly to reach a reaction temperature rapidly and the reaction time can be shortened, and the chitosan polyvinyl alcohol foam layer is dewatered by use of a vacuum freeze-drying method.

Description

[0001] This application is a divisional application based on the original application with an application date of July 2, 2013, an application number of 201310278304.X, and an invention titled "Shell Iodine Composite Biomedical Film and Its Preparation Method". technical field [0002] The invention belongs to the field of medical materials, and relates to an iodine-shell (antibacterial) wet biocomposite functional dressing, in particular to an improved product of the second part of an iodine-shell composite biomedical film (paste) and a preparation method thereof. Background technique [0003] As a covering for wounds, medical dressings can replace damaged skin to act as a temporary barrier during wound healing, avoid or control wound infection, and provide an environment conducive to wound healing. With the aging of the population and the increase of chronic ulcer wounds, the biomaterials closely related to wound repair involve various dressings and coverings on the wound s...

Claims

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Application Information

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IPC IPC(8): A61L15/24A61L15/28A61L15/26A61L15/32A61L15/44C08J5/18
Inventor 杨玉民
Owner ZHEJIANG SANCHUANG BIOTECH
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