Milbemycin oxime nano suspension for treating dog parasitic diseases and preparation method thereof

A nano-suspension, mirbe oxime technology, applied in the directions of liquid delivery, emulsion delivery, drug combination, etc., can solve the problems of mirbe oxime insolubility in water, limited application, etc., and achieves improved bioavailability, convenient operation, Effects with few side effects

Inactive Publication Date: 2014-12-17
ZHENGZHOU HOUYI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a kind of milbexime nanosuspension for treating canine parasitic disease, solve the problem that limits its application because milbexime is insoluble in water

Method used

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  • Milbemycin oxime nano suspension for treating dog parasitic diseases and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] The milbexime nanosuspension used for the treatment of canine parasitic diseases in this embodiment contains milbexime 2g, polysorbate 800.1ml, glycerol 2.0g, sodium carboxymethylcellulose in every 100ml suspension 1.0g, sodium citrate 1.0g, and the balance is purified water.

[0027] The preparation method of the milbexime nanosuspension for the treatment of canine parasitic diseases of the present embodiment comprises the following steps:

[0028] 1) Take 2g of dried milbexime, grind it into a fine powder in a mortar, add 0.1ml of polysorbate 80, 2.0g of glycerol, mix evenly, and then mix with fully swollen sodium carboxymethylcellulose glue (Add 1.0g sodium carboxymethylcellulose to 10ml purified water to make glue) and mix to obtain mixture A;

[0029] 2) Dissolve 1.0 g of sodium citrate in purified water to obtain mixture B;

[0030] 3) After mixing mixture A and mixture B, add purified water to the full amount to obtain mixture C;

[0031] 4) Repeat the homogen...

Embodiment 2

[0033] The milbexime nanosuspension used for the treatment of canine parasitic diseases of the present embodiment contains milbexime 3g, polysorbate 800.4ml, glycerol 2.0g, sodium carboxymethylcellulose in every 100ml suspension 2.5g, sodium tartrate 1.5g, and the balance is water for injection.

[0034] The preparation method of the milbexime nanosuspension for the treatment of canine parasitic diseases of the present embodiment comprises the following steps:

[0035] 1) Take 3g of dried milbexime, grind it into a fine powder in a mortar, add 0.4ml of polysorbate 80, 2.0g of glycerol, mix evenly, and then mix it with fully swollen sodium carboxymethylcellulose mucilage (Add 2.5g sodium carboxymethylcellulose to 10ml water for injection to make glue) and mix to obtain mixture A;

[0036] 2) Add 1.5 g of sodium tartrate into water for injection and dissolve to obtain mixture B;

[0037] 3) After mixing mixture A and mixture B, add water for injection to the full amount to obt...

Embodiment 3

[0040] The milbexime nanosuspension used for the treatment of canine parasitic diseases of the present embodiment contains milbexime 4g, polysorbate 800.4ml, glycerol 2.0g, methylcellulose 2.5g in every 100ml suspension 1. Sodium citrate 2.0g, and the balance is water for injection.

[0041] The preparation method of the milbexime nanosuspension for the treatment of canine parasitic diseases of the present embodiment comprises the following steps:

[0042] 1) Take 4g of dried milbexime, grind it into a fine powder in a mortar, add 0.4ml of polysorbate 80, 2.0g of glycerin and mix evenly, and then mix it with fully swollen methyl cellulose mortar (the Add 2.5g of methylcellulose to 10ml of purified water to make a glue) and mix to obtain mixture A;

[0043] 2) Dissolve 2.0g of sodium citrate in purified water to obtain mixture B;

[0044] 3) After mixing mixture A and mixture B, add purified water to the full amount to obtain mixture C;

[0045] 4) Repeat the homogenization ...

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Abstract

The invention discloses a milbemycin oxime nano suspension for treating dog parasitic diseases and a preparation method thereof. Each 100 mL of suspension contains 2 to 5 grams of milbemycin oxime, 0.1 to 0.4 mL of wetting agent, 3.0 to 5.5 grams of suspending agent, 1.0 to 2.0 grams of flocculating agent, and the balance being purified water or injection water. The provided milbemycin oxime nano suspension is mainly made of milbemycin oxime, and at the same time, a wetting agent, a suspending agent, and a flocculating agent are added, so the milbemycin oxime nano suspension has a stable property and can be used to prepare oral or injection drugs. The detention time of the drugs in human body is prolonged, thus the drugs can be fully absorbed by human body, and the biological utilization degree is improved. The milbemycin oxime nano suspension is used to treat dog in-vitro/in-vivo parasitic diseases in clinic and has the advantages of safety, good curative effect, little side effect, and user-friendliness.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicine, and in particular relates to a milbexime nanosuspension for treating canine parasitic diseases, and also relates to a preparation method of the milbexime nanosuspension for treating canine parasitic diseases . Background technique [0002] Parasitic disease is a kind of disease that pets are relatively easy to get. Usually, parasites cause mechanical damage to pets by consuming nutrients in pets, causing pets to suffer from slow growth, stagnation, emaciation, anemia, and emaciation due to lack of nutrition; or miscarriage, stillbirth, loss of fertility; or rough skin , dermatitis, itching, hair loss, frailty, decreased immunity, disease resistance, prone to diseases, infectious diseases, etc. After pets suffer from parasitic diseases, due to frequent contact with humans, most of the parasites can be transmitted to humans through pets, resulting in stunted children, mental retardati...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/10A61K31/365A61P33/00
Inventor 王丽景陈建晖李建正
Owner ZHENGZHOU HOUYI PHARMA
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