Preparation method of silver-loaded meso-porous silicon/collagen/polyvinyl acetal antimicrobial dressing

A technology of polyvinyl alcohol and mesoporous silicon, applied in medical science, absorbent pads, bandages, etc., can solve problems such as unsatisfactory tensile strength of wound dressings, insufficient mechanical strength of products, and poor resistance to wound adhesion, so as to promote wound healing , dense and uniform voids, and long release period

Inactive Publication Date: 2014-12-24
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, Chinese patent 201110427726.X discloses a preparation method of marine source composite collagen dressing; Chinese patent 201310079643.5 discloses medical collagen dressing and its preparation method and application; Chinese patent 03135277.4 discloses hydrophilic polyurethane wound dressing and its preparation method; Chinese patent 88105184.5 discloses the production method of medical polymer transparent dressing; Cheng Liping et al. Preparation of dressing and research on its sterilizing effect; Peng Rui et al [Peng Rui, Zou Yang, Liu Yong. Preparation and analysis of physical and chemical properties of gelatin and bletilla jelly-loaded biological dressings.

Method used

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  • Preparation method of silver-loaded meso-porous silicon/collagen/polyvinyl acetal antimicrobial dressing
  • Preparation method of silver-loaded meso-porous silicon/collagen/polyvinyl acetal antimicrobial dressing
  • Preparation method of silver-loaded meso-porous silicon/collagen/polyvinyl acetal antimicrobial dressing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] (1) Dissolve 0.2g of silver nitrate in 10ml of deionized water to obtain an aqueous solution of silver nitrate; ultrasonically disperse 0.1g of mesoporous silicon in 10ml of aqueous silver nitrate, and vibrate on a shaker at 45rpm for 72h to obtain a suspension; the suspension Freeze-drying for 48 hours after freezing to obtain silver-loaded mesoporous silicon;

[0028] (2) Preparation of silver-loaded mesoporous silicon / collagen / polyvinyl alcohol blend: 0.05g collagen was dissolved in 5mL 1% (wt.) acetic acid aqueous solution to obtain 1.0% (wt.) collagen solution; Heat to boiling at 90-100°C, dissolve 0.05g of polyvinyl alcohol-AH26 in 5mL of boiling deionized water, and cool to obtain a 1.0% (wt.) polyvinyl alcohol solution; ultrasonically disperse 0.05g of silver-loaded mesoporous silicon in In the collagen solution, obtain the silver-loaded mesoporous silica / collagen blend solution; mix 5mL silver-loaded mesoporous silica / collagen blend solution and 5mL polyvinyl a...

Embodiment 2

[0032] (1) Dissolve 0.1g of silver nitrate in 10ml of deionized water to obtain an aqueous solution of silver nitrate; ultrasonically disperse 0.15g of mesoporous silicon in 10ml of aqueous silver nitrate, and vibrate on a shaker at 30rpm for 24h to obtain a suspension; the suspension Freeze-drying for 72 hours after freezing to obtain silver-loaded mesoporous silicon;

[0033] (2) Preparation of silver-loaded mesoporous silicon / collagen / polyvinyl alcohol blend solution: 0.075g collagen was dissolved in 5mL 2% (wt.) acetic acid aqueous solution to obtain 1.5% (wt.) collagen solution; Heat to boiling at 90-100°C, dissolve 0.1125g polyvinyl alcohol-AH26 in 7.5mL boiling deionized water, and cool to obtain a 1.5% (wt.) polyvinyl alcohol solution; ultrasonically disperse 0.1g of silver-loaded mesoporous silicon In the collagen solution, the silver-loaded mesoporous silica / collagen blend was obtained; 5mL of the silver-loaded mesoporous silica / collagen blend was mixed with 7.5mL of...

Embodiment 3

[0037] (1) Dissolve 0.3g of silver nitrate in 10ml of deionized water to obtain an aqueous solution of silver nitrate; ultrasonically disperse 0.2g of mesoporous silicon in 10ml of aqueous silver nitrate, and vibrate on a shaker at 60rpm for 36h to obtain a suspension; the suspension Freeze-drying for 24 hours after freezing to obtain silver-loaded mesoporous silicon;

[0038] (2) Preparation of silver-loaded mesoporous silicon / collagen / polyvinyl alcohol blend: 0.025g collagen was dissolved in 5mL 3% (wt.) acetic acid aqueous solution to obtain 0.5% (wt.) collagen solution; Heat to boiling at 90-100°C, dissolve 0.3g of polyvinyl alcohol-AH26 in 60mL of boiling deionized water, and cool to obtain a 0.5% (wt.) polyvinyl alcohol solution; ultrasonically disperse 0.15g of silver-loaded mesoporous silicon in In the collagen solution, a silver-loaded mesoporous silica / collagen blend was obtained; 5 mL of the collagen solution and 6 mL of polyvinyl alcohol solution were mixed and sti...

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Abstract

The invention discloses a preparation method of a silver-loaded meso-porous silicon/collagen/polyvinyl acetal antimicrobial dressing. The method comprises the following steps: vibrating meso-porous silicon in a silver nitrate solution to obtain silver-loaded meso-porous silicon; preparing a collagen solution, and mixing the silver-loaded meso-porous silicon with the collagen solution to obtain a silver-loaded meso-porous silicon/collagen blend solution; dissolving polyvinyl alcohol into boiling water, cooling, mixing with the silver-loaded meso-porous silicon/collagen blend solution evenly, so as to obtain a silver-loaded meso-porous silicon/collagen/polyvinyl alcohol blend solution; dissolving polyvinyl alcohol, adding lauryl sodium sulfate, a formaldehyde solution and calcium carbonate, stirring, adding hydrochloric acid and stirring to obtain polyvinyl acetal; and adding a polyvinyl alcohol/silver-loaded meso-porous silicon/collagen blend solution, and solidifying to obtain the silver-loaded meso-porous silicon/collagen/polyvinyl acetal antimicrobial dressing. The medical dressing prepared by the method is long in silver ion release cycle, has effective antibacterial ability, simultaneously is capable of promoting wound healing, has good mechanical strength, air permeability, hygroscopic property and foaming ability, and can be applied to wound treatment.

Description

technical field [0001] The invention belongs to the technical field of preparation of medical dressings, and in particular relates to a preparation method of a silver-loaded mesoporous silicon / collagen / acetalized polyvinyl alcohol antibacterial dressing. Background technique [0002] The correct treatment of surgical wounds is one of the keys to the success of surgical treatment, and good wound healing is the prerequisite for the recovery of body functions after trauma. Therefore, research on accelerating wound healing is very important, and the development of wound dressings is one of the hotspots of research. one. Research on wound healing shows that the purpose of using dressings is not only to cover the wound surface, but also to promote wound healing. According to the "moist wound healing" theory, wounds heal faster in a moist environment. An ideal dressing should be able to prevent bacterial invasion, cover and protect the wound from infection. At present, antibiotic...

Claims

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Application Information

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IPC IPC(8): C08J9/00C08J3/24C08L89/00C08L29/14C08K7/24C08F16/06C08F8/28C08J9/08A61L15/32A61L15/24A61L15/18A61L15/44
Inventor 魏坤许为康
Owner SOUTH CHINA UNIV OF TECH
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