Preparation method of silver-loaded meso-porous silicon/collagen/polyvinyl acetal antimicrobial dressing

Abstract

The invention discloses a preparation method of a silver-loaded meso-porous silicon / collagen / polyvinyl acetal antimicrobial dressing. The method comprises the following steps: vibrating meso-porous silicon in a silver nitrate solution to obtain silver-loaded meso-porous silicon; preparing a collagen solution, and mixing the silver-loaded meso-porous silicon with the collagen solution to obtain a silver-loaded meso-porous silicon / collagen blend solution; dissolving polyvinyl alcohol into boiling water, cooling, mixing with the silver-loaded meso-porous silicon / collagen blend solution evenly, so as to obtain a silver-loaded meso-porous silicon / collagen / polyvinyl alcohol blend solution; dissolving polyvinyl alcohol, adding lauryl sodium sulfate, a formaldehyde solution and calcium carbonate, stirring, adding hydrochloric acid and stirring to obtain polyvinyl acetal; and adding a polyvinyl alcohol / silver-loaded meso-porous silicon / collagen blend solution, and solidifying to obtain the silver-loaded meso-porous silicon / collagen / polyvinyl acetal antimicrobial dressing. The medical dressing prepared by the method is long in silver ion release cycle, has effective antibacterial ability, simultaneously is capable of promoting wound healing, has good mechanical strength, air permeability, hygroscopic property and foaming ability, and can be applied to wound treatment.

Description

technical field [0001] The invention belongs to the technical field of preparation of medical dressings, and in particular relates to a preparation method of a silver-loaded mesoporous silicon / collagen / acetalized polyvinyl alcohol antibacterial dressing. Background technique [0002] The correct treatment of surgical wounds is one of the keys to the success of surgical treatment, and good wound healing is the prerequisite for the recovery of body functions after trauma. Therefore, research on accelerating wound healing is very important, and the development of wound dressings is one of the hotspots of research. one. Research on wound healing shows that the purpose of using dressings is not only to cover the wound surface, but also to promote wound healing. According to the "moist wound healing" theory, wounds heal faster in a moist environment. An ideal dressing should be able to prevent bacterial invasion, cover and protect the wound from infection. At present, antibiotic...

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Problems solved by technology

For example, Chinese patent 201110427726.X discloses a preparation method of marine source composite collagen dressing; Chinese patent 201310079643.5 discloses medical collagen dressing and its preparation method and application; Chinese patent 03135277.4 discloses hydrophilic polyurethane wound dressing and its preparation method; Chinese patent 88105184.5 discloses the production method of medical polymer transparent dressing; Cheng Liping et al. Preparation of dressing and research on its sterilizing effect; Peng Rui et al [Peng Rui, Zou Yang, Liu Yong. Preparation and analysis of physical and chemical properties of gelatin and bletilla jelly-loaded biological dressings. Journal of Clinical and Experimental Medicine. 2007.6.142-143 ] also analyzed the preparation and physical and chemical properties of gelatin and bletilla jelly drug-loaded biological dressings; Combined method, the preparation process is complicated, the mechanical strength of the product is not enough, and it is easy to be damaged; Ye Chunting et al. 606] reported the performance of polyvinyl alcohol-collagen wound dressings, but the tensile strength of the prepared wound dressings was not ideal

However, domestic medical sponges currently available on the market also generally have shortcomings such as low strength, poor resistance to wound adhesion, and easy inflammation.

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