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Etodolac capsule and preparation method thereof

A technology of etodolac and capsules, which is applied in the field of medicine, can solve the problems that the capsule shell is difficult to disintegrate and the drug cannot be released, and achieves the effects of simple preparation process, fewer types of excipients, and less dosage

Active Publication Date: 2015-01-07
SHANDONG NEWTIME PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, etodolac is mainly in capsules on the market, but due to the strong acidity of etodolac, it is easy to cross-link with the gelatin in the capsule shell during the long-term storage of the capsule, which makes the capsule shell difficult to disintegrate. unable to release

Method used

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  • Etodolac capsule and preparation method thereof
  • Etodolac capsule and preparation method thereof
  • Etodolac capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] etodolac 200g

[0019] Phosphate buffer saline

[0020] Magnesium Stearate 1g

[0021] Preparation Process:

[0022] Pass etodolac through 100 sieves, weigh the prescription amount, and set aside; prepare potassium dihydrogen phosphate and potassium hydroxide buffer solution, adjust the pH to 6.5, use the buffer solution as a binder, granulate etodolac raw materials, and dry at 60°C , through a 20-mesh sieve, then mixed with magnesium stearate, and filled into capsules.

Embodiment 2

[0024] etodolac 200g

[0025] Phosphate buffer saline

[0026] Talc powder 1g

[0027] Preparation Process:

[0028] Pass etodolac through 120 sieves, weigh the prescription amount, and set aside; prepare potassium dihydrogen phosphate and potassium hydroxide buffer solution, adjust the pH to 8.5, use the buffer solution as a binder, granulate etodolac raw materials, and dry at 50°C , through a 18-mesh sieve, mixed with magnesium stearate, and filled into capsules.

Embodiment 3

[0030] etodolac 200g

[0031] Phosphate buffer saline

[0032] Talc powder 1g

[0033] Preparation Process:

[0034] Pass etodolac through 120 sieves, weigh the prescription amount, and set aside; prepare potassium dihydrogen phosphate and potassium hydroxide buffer solution, adjust the pH to 7.5, use the buffer solution as a binder, granulate etodolac raw materials, and dry at 60°C , through a 18-mesh sieve, mixed with magnesium stearate, and filled into capsules.

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Abstract

The invention discloses an etodolac capsule and a preparation method thereof. The etodolac capsule consists of etodolac acid, monopotassium phosphate, potassium hydroxide and a lubricant. Compared with the prior art, the etodolac capsule is simple in preparation process and suitable for industrial production, and has the advantages that the crosslinking of the etodolac acid and gelatin is avoided, the drug digestion is not remarkably changed after long-time and accelerated observation and the accessory type and dosage are less.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to an etodolac capsule and a preparation method thereof. Background technique [0002] Rheumatoid arthritis is a common chronic inflammatory joint disease. Clinical studies have shown that the onset of rheumatoid arthritis is approximately diurnal. The patient's symptoms such as pain, morning stiffness, inflammation, etc. are aggravated in the morning and relieved in the afternoon and night. [0003] Anti-inflammatory drugs are divided into two categories: steroidal and non-steroidal. Among them, non-steroidal anti-inflammatory drugs are widely used and have significant curative effects. They mainly inhibit the synthesis of prostaglandins by inhibiting cyclooxygenase, thereby exerting anti-inflammatory effects. , Analgesic and antipyretic effects. Among them, cyclooxygenase has two isomers, namely cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2). COX-1 is an ess...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K31/407A61K47/02A61K47/12A61K47/04
Inventor 赵志全郝贵周曹淑忠张瑜
Owner SHANDONG NEWTIME PHARMA
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