Florfenicol supermolecule preparation and preparation method thereof

Abstract

The invention discloses a florfenicol supermolecule preparation and a preparation method thereof. The preparation is prepared from the following raw materials in parts by weight: 5-10 parts of florfenicol, 5-20 parts of soybean protein isolate, 5-20 parts of maltodextrin, 10-40 parts of ethyl alcohol-purified water with the mass ratio of 1 to 1, and 20-80 parts of one or several of glucose, cane sugar with particle diameter of 80 meshes, or HPMC (Hydroxypropyl Methylcellulose). The preparation technology comprises the steps as follows: firstly, the soybean protein isolate and the maltodextrin are mixed into graft polymer of the soybean protein isolate and the maltodextrin as a supermolecule object; secondly, obtained florfenicol emulsion is put into a reaction kettle so as to be subjected to ultrasound for 30-60 minutes, and supermolecule micro emulsion is formed with florfenicol molecules being embedded in the graft polymer object of the soybean protein isolate and the maltodextrin, and dried; thirdly, after the drying, auxiliary materials are put in additionally for obtaining the preparation. The florfenicol supermolecule preparation obtained through the method provided by the invention is high in bioavailability, simple, convenient and economic in technology, high in production efficiency, safe and environmental-friendly, and good in reproducibility; moreover, the obtained products can be mixed with feeds or be mixed with drinks, and the preparation is convenient for pharmacy, and can be mixed with feeds or water, thereby receiving welcome from the majorities of farmers deeply.

Description

technical field [0001] The invention relates to a veterinary drug production process preparation, in particular to a florfenicol supramolecular preparation and a preparation method thereof. Background technique [0002] Florfenicol (Florfenicol) Chinese name: fluprofen, florfenicol or florfenicol, is a new veterinary-specific broad-spectrum antibacterial drug of chloramphenicol successfully developed in the late 1980s. It was first launched in Japan in 1990. In 1993, Norway approved the drug to treat salmon furunculosis. In 1995, France, the United Kingdom, Austria, Mexico and Spain approved it to treat bovine respiratory system bacterial diseases. In Japan and Mexico, it is also approved as a feed additive for pigs to prevent and treat bacterial diseases in pigs (Qiu Yinsheng et al., 1996). The production process of florfenicol powder is simple, and it is only prepared by simple mixing with auxiliary materials. However, it is time-consuming and laborious to mix with feed d...

AI Technical Summary

Problems solved by technology

The production process of florfenicol powder is simple, and it is only prepared by simple mixing with auxiliary materials. However, it is time-consuming and laborious to mix with feed during use, which is likely to cause disadvantages such as uneven mixing and inaccurate dosage of mixed feeding. The bioavailability lower

Among the retrieved prior art: the Chinese invention patent with the application number 201210138126 discloses a florfenicol soluble powder and its preparation method, which can be made into a soluble powder, which is convenient and feasible for laboratory preparation, but its preparation process Complicated, not conducive to industrial promotion

The application number is 201010160013, which discloses a water-soluble micropowder containing florfenicol and its preparation method. It is only a simple physical mixing, and its palatability is poor and its water-soluble effect is not good.

The recently published patent: the Chinese invention patent with the application number 201310099557 discloses a production method for preparing florfenicol microcrystals, which contains organic solvents and consumes a large amount, and has relatively large toxicity and irritation, which is clinically applicable. Unsafe at times, great damage to animal organisms, and high cost of organic solvents

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