Enteric-coated vegetable cellulose hard hollow capsule and preparation method thereof

Abstract

The invention relates to enteric-coated plant cellulose hard empty capsules and a preparation method thereof. The hard empty capsules are prepared by mixing and processing the following raw materials in percentage by weight: 20-28 percent of plant cellulose derivatives, 10-16 percent of pectin, 0.2-0.25 percent of surfactant, 0.1-5 percent of coagulant aids, 0-0.05 percent of coloring agent, 0-5 percent of titanium dioxide, 0.1-0.5 percent of plasticizer and the balance of water, wherein the surfactant is selected from lauryl sodium sulfate or Tween 80; the plasticizer is selected from glycerin or polyethylene glycol; the coagulant aids are selected from any one or several out of sodium alga acid, agar, carrageenan and cooling gel; and the coloring agent refers to any one out of a synthetic coloring agent, a natural coloring agent and a plant coloring agent. The enteric-coated plant cellulose hard empty capsules disclosed by the invention comprise the main raw materials such as plant cellulose derivatives and pure natural plant polysaccharide pectin, the pectin serving as a main ingredient is uniformly distributed in the hard empty capsules, and the prepared hard empty capsules do not need outer coatings, so that gastric acid resistance can be realized, the hard empty capsules do not disintegrate in the stomach, the hard empty capsules and the contained drugs are not subjected to a cross-linking reaction, and thus the safety is high.

Description

technical field [0001] The invention relates to an enteric-coated plant cellulose hard hollow capsule and a preparation method thereof, belonging to the technical field of pharmaceutical excipients. Background technique [0002] The hard hollow capsule shell is the main outer packaging material for filling medicine and health food, and it is taken into the body together with the endocytosis, which reduces the trouble of entrance and increases the curative effect. Traditional gelatin capsules use gelatin hydrolyzed from animal skin and bone as the main raw material. Although gelatin has good properties in the preparation of hollow capsules, the source is limited, and with the frequent occurrence of mad cow disease, foot-and-mouth disease, bird flu and other diseases It was discovered that the quality problems of gelatin capsules themselves caused consumers to question and worry. [0003] At present, the following problems are prone to occur in the production process of plant...

AI Technical Summary

Problems solved by technology

Traditional gelatin capsules use gelatin hydrolyzed from animal skin and bone as the main raw material. Although gelatin has good properties in the preparation of hollow capsules, the source is limited, and with the frequent occurrence of mad cow disease, foot-and-mouth disease, bird flu and other diseases The quality problems of gelatin capsules have caused consumers to question and worry

[0003] At present, the following problems are prone to occur in the production process of plant-based hollow capsules: if the raw material of the product has low water content (more solids), the raw material will have poor fluidity and poor homogeneity. If the water content of raw materials is increased and the fluidity of raw materials is improved, the drying and molding process of the product will be longer, and the power consumption will increase. Moreover, due to the loss of water, the uncertainty of product molding will increase. Affect the pass rate of finished products. The empty capsules prepared by the existing production process have the disadvantages of different wall thicknesses, large differences in water content, low pass rate, and high energy consumption, and the traditional gelatin empty capsules disintegrate within 10 minutes in gastric acid , released, but some of the contents in the capsule are irritating to the stomach, or unstable in case of acid, and need to be disintegrated in the intestine to exert curative effect