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A method for preparing liquid crystal molecularly imprinted monolithic columns with chiral molecules as dopants

A technology of chiral molecules and liquid crystal molecules, applied in chemical instruments and methods, other chemical processes, etc., can solve the problems of inability to chromatographic stationary phase, difficult to resist high pressure of HPLC, etc., and achieve the effect of high imprinting effect

Inactive Publication Date: 2016-03-30
TIANJIN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the liquid crystal MIPs directly prepared by using liquid crystal monomers are difficult to resist the high pressure of HPLC due to their elasticity, so they cannot be directly used as chromatographic stationary phases.

Method used

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  • A method for preparing liquid crystal molecularly imprinted monolithic columns with chiral molecules as dopants
  • A method for preparing liquid crystal molecularly imprinted monolithic columns with chiral molecules as dopants
  • A method for preparing liquid crystal molecularly imprinted monolithic columns with chiral molecules as dopants

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Preparation of liquid crystal low cross-linked amlodipine molecularly imprinted monolithic column induced by chiral dopant L-naproxen and evaluation of its imprinting effect.

[0034] A chiral dopant-induced liquid crystal low cross-linked amlodipine molecularly imprinted monolithic column was synthesized by surface imprinting method, and its retention performance was evaluated by connecting it to high performance liquid chromatography under appropriate chromatographic conditions. Synthetic reaction conditions and processing method are as follows:

[0035] Preparation of amlodipine as template molecularly imprinted monolithic column by surface imprinting method:

[0036]a. The initiator azobisisobutyronitrile with a mass fraction of 0.50% is dissolved in the porogen toluene with a mass fraction of 18.17% and dodecyl alcohol with a mass fraction of 51.70%, and then added trimethylol with a mass fraction of 29.63% propane trimethacrylate, ultrasonic 10min, pour the mixtu...

Embodiment 2

[0041] Preparation of liquid crystal low cross-linked amlodipine molecularly imprinted monolithic column induced by chiral dopant levoibuprofen and evaluation of its imprinting effect.

[0042] In order to demonstrate that the effect of chiral dopants on the overall imprinting effect of low-crosslinked amlodipine liquid crystal molecules is universal, we synthesized the addition of different chiral dopants (levo-ibuprofen) and the corresponding racemization Molecularly imprinted monolithic column of amlodipine with molecule as dopant. The specific operation steps are as follows:

[0043] a. The initiator azobisisobutyronitrile with a mass fraction of 0.50% is dissolved in the porogen toluene with a mass fraction of 18.17% and dodecyl alcohol with a mass fraction of 51.70%, and then added trimethylol with a mass fraction of 29.63% propane trimethacrylate, ultrasonic 10min, pour the mixture into a stainless steel column (1004.6mmI.D.), seal it up and let it stand vertically in ...

Embodiment 3

[0048] Preparation of monolithic columns for molecular imprinting of liquid crystals with low cross-linking amlodipine induced by chiral dopant levofloxacin and evaluation of their imprinting effects.

[0049] In order to further demonstrate the generality of the effect of chiral dopants on the imprinting effect of low-crosslinked amlodipine liquid crystal molecular monolithic imprinted columns, we also synthesized amlodipine molecularly imprinted monolithic columns added with levofloxacin dopant. The specific operation steps are as follows:

[0050] a. The initiator azobisisobutyronitrile with a mass fraction of 0.50% is dissolved in the porogen toluene with a mass fraction of 18.17% and dodecanol with a mass fraction of 51.7%, and then added trimethylol with a mass fraction of 29.63% propane trimethacrylate, ultrasonic 10min, pour the mixture into a stainless steel column (1004.6mmI.D.), seal it up and let it stand vertically in a constant temperature water bath at 48°C for ...

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Abstract

The invention relates to a method for preparing a monolithic liquid crystal molecular imprinting column by using chiral molecules as a doping agent. A synthesis method is a surface imprinting method. The method comprises the following steps: adding a liquid crystal monomer and a chiral molecule doping agent into a polymerization system, and injecting a pre-polymerization mixed solution in a monolithic polymer framework material column synthesized in advance for polymerization to obtain a low-crosslinking molecular imprinting polymer (MIP) which has a fixed hole size and shape and has functions of determining arrangement of functional groups and identifying template molecules, wherein with the added chiral doping agent, the liquid crystal monomer MPDE (Methyl Phenyl Dicyclohexyl Ethylene) can be converted into a cholesteric phase from a nematic phase, and the imprinting identifying effect is enhanced by adopting an identifying hole generated by a helix and a hole generated by imprinting. The monolithic liquid crystal molecular imprinting column prepared by adopting the method has a good imprinting effect, an imprinting factor reaches up to 22.3, meanwhile, the defect that the applied liquid crystal monomer does not resist high pressure is overcome, and the permeability is high.

Description

technical field [0001] The invention relates to the preparation of a molecularly imprinted monolithic column, specifically a method for preparing a liquid crystal molecularly imprinted monolithic column with chiral molecules as a dopant, which can be applied to the field of molecular recognition. Background technique [0002] Molecular imprinting technique (MIT), also known as molecular imprinting, is a technique developed on the basis of simulating the interaction of enzyme-substrate and receptor-antibody in nature to synthesize a preselective stationary phase. In this method, the force between the template and the functional monomer is used for pre-assembly to form a stable complex. This force and the shape of template molecules can be fixed in the formed molecularly imprinted polymers (MIPs) through polymerization and cross-linking. After the template is removed by elution, the cavity of the template is left, and the template molecule can be recognized. The polymer prepa...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J20/285B01J20/29B01J20/30C08F220/06C08F222/14C08F122/14C08J9/26
CPCB01J20/285B01J20/29B01J20/3085B01J2220/4812B01J2220/52C08F122/14C08F220/06C08J9/26C08J2333/02C08F222/14
Inventor 刘照胜张静黄艳萍
Owner TIANJIN MEDICAL UNIV
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