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Method for rapidly preparing granular lactitol

A lactitol and granular technology, which is applied in the field of preparation of granular lactitol, can solve the problems of unseen granular lactitol, cannot use tablets, poor compressibility, etc., achieves good compressibility, improves purity and quality, and reduces production cost effect

Active Publication Date: 2015-01-28
山东绿健生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

U.S. Patent No. 5,516,763 has introduced a method of evaporating the lactitol solution to a solid content of 77-88%, cooling to a temperature range of 30-75°C, and then separating the crystalline lactitol monohydrate from the mother liquor. Humidity of 0-40% and drying with air to obtain crystallization of lactitol monohydrate, but it takes 24 hours, which lasts a long time, and has poor compressibility, so it cannot be used to prepare tablets
[0007] At present, there are no related reports on the preparation of granular lactitol and its use in the preparation of tablets and as excipients

Method used

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  • Method for rapidly preparing granular lactitol
  • Method for rapidly preparing granular lactitol

Examples

Experimental program
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Effect test

Embodiment 1

[0023] 500g of lactitol seed crystals that have been crushed and screened, the content of lactitol in the lactitol seed crystals is at least 95%, and the average particle size after screening is 20-100 μm. The crystalline water is crushed and sieved, and the screened lactose crystal seeds are placed in a DPL multifunctional granulator. The air inlet temperature is controlled at 60°C, the material temperature is 40°C, and the spray speed is 5.5ml / min. The pressure is 3bar, and the spraying time is 10min. Dissolve 60g of lactitol seed crystals in 40g of water to make a lactitol syrup with a mass concentration of 60%, concentrate it to a dry matter concentration of more than 98%, and spray the syrup at a speed of 6ml / min Spray on the lactitol seed crystals flowing in the granulator by cutting spray. Then cooled to room temperature, the lactitol content of the obtained product is 99.32%, the moisture content is 0.43%, the particle size is 60 μm, the apparent density is 0.7g / ml, th...

Embodiment 2

[0025] 500g of lactitol seed crystals that have been crushed and screened, the content of lactitol in the lactitol seed crystals is at least 95%, and the average particle size after screening is 20-100 μm. The crystalline water is crushed and sieved, and the screened lactose crystal seeds are placed in a DPL multifunctional granulator. The air inlet temperature is controlled at 70°C, the material temperature is 50°C, the spray speed is 5ml / min, and the atomizing air pressure is 3bar, spraying time is 10min, 65g lactitol seed crystals are dissolved in 35g water to make a lactitol syrup with a mass concentration of 65%, concentrated to a dry matter concentration of more than 98%, and the syrup is pressed at a speed of 8ml / min Spray by cutting spray on the lactitol seed crystals flowing in the granulator. Then cooled to room temperature, the lactitol content of the obtained product is 99.53%, the moisture content is 0.35%, the particle size is 65 μm, the apparent density is 0.72g...

Embodiment 3

[0027] 500g of lactitol seed crystals that have been crushed and screened, the content of lactitol in the lactitol seed crystals is at least 95%, and the average particle size after screening is 20-100 μm. The crystalline water is crushed and sieved, and the screened lactose crystal seeds are placed in a DPL multifunctional granulator, the air inlet temperature is controlled at 80°C, the material temperature is 60°C, the spray speed is 4ml / min, and the atomization air pressure is 3bar, spraying time is 10min, 70g lactitol seed crystals are dissolved in 30g water to make a lactitol syrup with a mass concentration of 70%, concentrated to a dry matter concentration of more than 98%, and the syrup is pressed at a speed of 10ml / min Spray by cutting spray on the lactitol seed crystals flowing in the granulator. Then cooled to room temperature, the lactitol content of the obtained product is 99.62%, the moisture content is 0.28%, the particle size is 70 μm, the apparent density is 0....

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Abstract

The invention relates to a method for rapidly preparing granular lactitol. The method specifically comprises the following steps: preparing lactitol syrup with a certain concentration, spraying onto lactitol seed crystals flowing in a fluidized bed granulator, and then cooling the granular lactitol to obtain a required material. The method has the benefits that the granular lactitol prepared by using the method disclosed by the invention is uniform in size distribution and low in time consumption, only about 2 hours is needed, crystal water is not contained, and the lactitol obtained through crystallization of common aqueous solution is monohydrate lactitol. The method disclosed by the invention is simple in technology, the purity reaches more than 99%, the production cost can be reduced, the purity and quality of the product are improved, the compressibility is good, and the granular lactitol can serve as an excipient or can be used for preparing tablets.

Description

technical field [0001] The invention relates to a method for preparing granular lactitol, in particular to a method for rapidly preparing granular lactitol. Background technique [0002] Lactitol, also known as lactitol, has a chemical name: 4-O-B-D-galactopyranosyl-D-sorbitol, and its structural formula is: [0003] [0004] It does not exist in nature. It is a product refined from lactose as raw material after reduction reaction. As a good tissue improver and sweetener, lactitol can be used in food industries such as chocolate, chewing gum, ice cream, beverages, and dairy products. Lactitol can provide foods with the fat-soluble properties and texture of sucrose, but the calories are only about 40% of sucrose. Lactitol does not affect blood sugar or insulin levels, so it is suitable for diabetics; it is a powerful growth factor for bifidobacteria in organisms, which can balance the imbalance of gastrointestinal flora, increase human immunity, and help recover from fat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H15/04C07H1/06
CPCC07H1/06C07H15/04
Inventor 信成夫景文利于丽张延秀任尚美刘建
Owner 山东绿健生物技术有限公司