Hydrogel eye drop carrier containing polymer micelle and preparation method of hydrogel eye drop carrier

A polymer glue and polymer technology, which can be used in pharmaceutical formulations, medical preparations with non-active ingredients, and non-active ingredients of polymer compounds. The effect of oxygen permeability, great social benefit and economic benefit

Active Publication Date: 2015-02-25
普润德百目通(北京)科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, polymer micelles usually exist in the form of solutions, lackin

Method used

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  • Hydrogel eye drop carrier containing polymer micelle and preparation method of hydrogel eye drop carrier
  • Hydrogel eye drop carrier containing polymer micelle and preparation method of hydrogel eye drop carrier
  • Hydrogel eye drop carrier containing polymer micelle and preparation method of hydrogel eye drop carrier

Examples

Experimental program
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Example Embodiment

[0062] Example 1

[0063] Dissolve 57.6mg β-CD in 10ml ultrapure water, then add 10ml 0.72% W / V PAA (number average molecular weight 100,000, the same below) aqueous solution and 10ml 0.44% W / V PEG (number average molecular weight 6000, below Same) Aqueous solution. The resulting mixture was stirred at room temperature for 24 hours and then allowed to stand overnight. The solution containing polymer micelles was dialyzed against a dialysis bag with a molecular weight cut-off of 3000 for 3 days, and the water was changed every 4 hours to remove free β-CD in the mixed solution to obtain a polymer micelle solution. The light transmittance of polymer micelles is greater than 90%, such as figure 1 M-0.1-50. The particle size is 64nm, the zeta potential is -20.1±0.8, the loading of ofloxacin in the polymer micelle is 3.26μg / ml, and the loading of puerarin in the polymer micelle is 6.17μg / ml. HEMA monomer (the volume ratio of water in the total system is 2:1) and 2wt% MPC monomer (0...

Example Embodiment

[0064] Example 2

[0065] Dissolve 5.8 mg of β-CD in 10 ml of ultrapure water, and then add 10 ml of 0.072% W / V PAA aqueous solution and 10 ml of 0.044% W / V PEG aqueous solution. The resulting mixture was stirred at room temperature for 24 hours and then allowed to stand overnight. The solution containing polymer micelles was dialyzed against a dialysis bag with a molecular weight cut-off of 3000 for 3 days, and the water was changed every 4 hours to remove free β-CD in the mixed solution to obtain a polymer micelle solution. The light transmittance of polymer micelles is greater than 95%, such as figure 1 M-0.01-50. The particle size is 39nm, the zeta potential is -29.7±0.9, and the loading of puerarin in the polymer micelles is 1.15μg / ml. HEMA monomer (the volume ratio of water in the total system is 2:1) and 2% MPC monomer (0.5% of the total mass of micellar liquid and monomer) are mixed, and then 35% polymer micelle aqueous solution (by mixing After the total mass of the ...

Example Embodiment

[0066] Example 3

[0067] Dissolve 28.8 mg of β-CD in 10 ml of ultrapure water, and then add 10 ml of 0.36% W / V PAA aqueous solution and 10 ml of 0.22% W / V PEG aqueous solution. The resulting mixture was stirred at room temperature for 24 hours and then allowed to stand overnight. The solution containing polymer micelles was dialyzed against a dialysis bag with a molecular weight cut-off of 3000 for 3 days, and the water was changed every 4 hours to remove free β-CD in the mixed solution to obtain a polymer micelle solution. The light transmittance of polymer micelles is greater than 95%, such as figure 1 The M-0.05-50. The particle size is 53nm, the zeta potential is -23.3±0.9, the loading of ofloxacin in polymer micelles is 1.94μg / ml, and the loading of puerarin in polymer micelles is 3.85μg / ml. HEMA monomer (the volume ratio of water in the total system is 2:1) and 2% MPC monomer (0.5% of the total mass of micellar liquid and monomer) are mixed, and then 35% polymer micelle...

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Abstract

The invention discloses a hydrogel eye drop carrier containing polymer micelle and a preparation method of the hydrogel eye drop carrier. The carrier is prepared by mixing polymer micelle liquid which consists of polyethylene glycol, polyacrylic acid and cyclodextrin with monomer hydroxyethyl methylacrylate and choline phosphate and then performing polymerization. The preparation method comprises the following steps: mixing and stirring a cyclodextrin aqueous solution, a polyethylene glycol aqueous solution and a polyacrylic acid aqueous solution, standing, then performing dialysis to obtain the polymer micelle liquid, mixing monomer hydroxyethyl methylacrylate and choline phosphate with the polymer micelle liquid, and then performing polymerization and demolding to obtain the hydrogel eye drop carrier. The novel hydrogel provided by the invention has good oxygen permeability and drug controlled release capability, the performance of the hydrogel meets requirements of a corneal contact lens, and the hydrogel can be used for controlling release of an eye drop, and has great social and economic benefits.

Description

technical field [0001] The invention belongs to the technical field of new materials, and specifically relates to the preparation of polymer micelles, the synthesis of composite hydrogels, and the loading and release of drugs in the hydrogels. Background technique [0002] The treatment of eye diseases is mainly done by drugs at present. In this process, too low drug concentration cannot play a therapeutic role; too high drug concentration will cause side effects and even damage normal tissues and organs. In addition, the therapeutic effect also depends on whether the drug can remain in the affected area for a sufficient time. Among the currently used ophthalmic preparations, more than 90% are eye drops or eye ointments, which stay in the eyes for only about 2 minutes, and only 1-7% of the drugs can be effectively used. Most of the drugs are discharged through the nasolacrimal duct or passed through The nasal cavity enters the blood system, causing disadvantages such as in...

Claims

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Application Information

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IPC IPC(8): A61K47/40A61K47/34A61K47/14A61K47/24A61P27/02
Inventor 胡小红王昕陈频张新燕马小涵董岩
Owner 普润德百目通(北京)科技有限公司
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