Strontium calcium silicate-containing biological ceramic as well as preparation method and application thereof
A technology of calcium strontium silicate and bioceramics, which is applied in the field of biomaterials to achieve good effects of promoting bone, good biological activity and promoting proliferation
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 In the case that the strontium-containing calcium silicate bioceramic is strontium-containing calcium silicate bioceramic particles, the preparation method includes: using soluble calcium salt as calcium source, using soluble strontium salt as strontium source, and using soluble sodium silicate as silicon source , according to the stoichiometric ratio, the chemical co-precipitation method is used to prepare the strontium-containing calcium silicate ceramic powder; Strontium-containing calcium silicate bioceramic particles. Specifically, as an example, the following steps may be included.
 (1) With soluble calcium salt as calcium source, soluble strontium salt as strontium source, and soluble sodium silicate as silicon source, according to the stoichiometric ratio (Ca 1-x Sr x SiO 3 , x=0.015~0.25) Weigh the raw materials respectively, dissolve soluble calcium salt and soluble strontium salt in water to prepare a mixed solution, so that the total concentration...
 Raw materials used are as described above, get 0.45mol of Ca (NO 3 ) 2 and 0.05mol of Sr(NO 3 ) 2 Dissolved in 1000mL deionized water, 0.5mol Na 2 SiO 3 Dissolve in 1000mL deionized water. the above Na 2 SiO 3 The solution was added to the Ca(NO 3 ) 2 After the addition, continue to stir for 12 hours, filter with suction and wash with deionized water for 3 times, dry at 80°C for 12 hours to obtain a dry powder, ball mill and pass through a 100-mesh nylon mesh sieve, and then calcined at 1100°C for 3 hours to obtain the component Sr10CS of powder;
 In addition, by adding 0.475 mol of Ca(NO 3 ) 2 and 0.025mol of Sr(NO 3 ) 2 Dissolve in 1000mL deionized water and mix with 1000mL Na with a concentration of 0.5mol / L 2 SiO 3The aqueous solution reacts to obtain the powder of Sr5CS. And by adding 0.4mol Ca(NO 3 ) 2 and 0.1mol of Sr(NO 3 ) 2 Dissolve in 1000mL deionized water and mix with 1000mL Na with a concentration of 0.5mol / L 2 SiO 3 Aqueous s...
 The raw materials used are as described above. The CS and Sr10CS powders prepared by the precipitation method were calcined at 1150 degrees for 5 hours, and then separated by sieving to obtain 300-450 micron particles as materials for repairing osteoporotic bone defects;
 The extracts of CS and Sr10CS particles were incubated with BMSCs-OVX cells to evaluate the effect of the material on bone marrow mesenchymal stem cells derived from osteoporotic bone. figure 2 The results showed that the doping of strontium significantly promoted the proliferation of BMSCs-OVX in the concentration range of 1 / 64~1 / 8 of the extract solution. It shows that strontium doping can significantly promote the proliferation ability of bone marrow mesenchymal stem cells in patients with osteoporosis. Figure 3a It is the staining pattern of the alkaline phosphatase (ALP) expression of BMSCs-OVX at the concentration of CS and Sr10CS bioceramic materials at 1 / 32 extract concentration, and...
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