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Strontium calcium silicate-containing biological ceramic as well as preparation method and application thereof

A technology of calcium strontium silicate and bioceramics, which is applied in the field of biomaterials to achieve good effects of promoting bone, good biological activity and promoting proliferation

Active Publication Date: 2015-03-25
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the application of strontium-containing calcium silicate bioceramics in the field of osteoporotic bone defect repair has not been reported.

Method used

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  • Strontium calcium silicate-containing biological ceramic as well as preparation method and application thereof
  • Strontium calcium silicate-containing biological ceramic as well as preparation method and application thereof
  • Strontium calcium silicate-containing biological ceramic as well as preparation method and application thereof

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preparation example Construction

[0039] In the case that the strontium-containing calcium silicate bioceramic is strontium-containing calcium silicate bioceramic particles, the preparation method includes: using soluble calcium salt as calcium source, using soluble strontium salt as strontium source, and using soluble sodium silicate as silicon source , according to the stoichiometric ratio, the chemical co-precipitation method is used to prepare the strontium-containing calcium silicate ceramic powder; Strontium-containing calcium silicate bioceramic particles. Specifically, as an example, the following steps may be included.

[0040] (1) With soluble calcium salt as calcium source, soluble strontium salt as strontium source, and soluble sodium silicate as silicon source, according to the stoichiometric ratio (Ca 1-x Sr x SiO 3 , x=0.015~0.25) Weigh the raw materials respectively, dissolve soluble calcium salt and soluble strontium salt in water to prepare a mixed solution, so that the total concentration...

Embodiment 1

[0068] Raw materials used are as described above, get 0.45mol of Ca (NO 3 ) 2 and 0.05mol of Sr(NO 3 ) 2 Dissolved in 1000mL deionized water, 0.5mol Na 2 SiO 3 Dissolve in 1000mL deionized water. the above Na 2 SiO 3 The solution was added to the Ca(NO 3 ) 2 After the addition, continue to stir for 12 hours, filter with suction and wash with deionized water for 3 times, dry at 80°C for 12 hours to obtain a dry powder, ball mill and pass through a 100-mesh nylon mesh sieve, and then calcined at 1100°C for 3 hours to obtain the component Sr10CS of powder;

[0069] In addition, by adding 0.475 mol of Ca(NO 3 ) 2 and 0.025mol of Sr(NO 3 ) 2 Dissolve in 1000mL deionized water and mix with 1000mL Na with a concentration of 0.5mol / L 2 SiO 3The aqueous solution reacts to obtain the powder of Sr5CS. And by adding 0.4mol Ca(NO 3 ) 2 and 0.1mol of Sr(NO 3 ) 2 Dissolve in 1000mL deionized water and mix with 1000mL Na with a concentration of 0.5mol / L 2 SiO 3 Aqueous s...

Embodiment 2

[0074] The raw materials used are as described above. The CS and Sr10CS powders prepared by the precipitation method were calcined at 1150 degrees for 5 hours, and then separated by sieving to obtain 300-450 micron particles as materials for repairing osteoporotic bone defects;

[0075] The extracts of CS and Sr10CS particles were incubated with BMSCs-OVX cells to evaluate the effect of the material on bone marrow mesenchymal stem cells derived from osteoporotic bone. figure 2 The results showed that the doping of strontium significantly promoted the proliferation of BMSCs-OVX in the concentration range of 1 / 64~1 / 8 of the extract solution. It shows that strontium doping can significantly promote the proliferation ability of bone marrow mesenchymal stem cells in patients with osteoporosis. Figure 3a It is the staining pattern of the alkaline phosphatase (ALP) expression of BMSCs-OVX at the concentration of CS and Sr10CS bioceramic materials at 1 / 32 extract concentration, and...

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Abstract

The invention relates to strontium calcium silicate-containing biological ceramic as well as a preparation method and an application thereof. The general formula of chemical constitution of the strontium calcium silicate-containing biological ceramic is Ca1-xSrxSiO3, wherein x is equal to 0.015 to 0.25. The strontium calcium silicate-containing biological ceramic is ceramic particles or porous ceramic. The strontium calcium silicate-containing biological ceramic disclosed by the invention, obtained by doping strontium into calcium silicate biological ceramic, has the advantages of both calcium silicate ceramic and strontium and is good in bioactivity and degradability, and silicon ions released by degradation of the strontium calcium silicate-containing biological ceramic have good effects of promoting proliferation of bone cells and stimulating expression of osteogenesis gene. Beside, an alkaline micro-environment formed by degradation of the material can achieve the effect of neutralizing an acidic micro-environment of osteoporotic bone; the strontium ions released by degradation have good dual functions of promoting osteogenesis and inhibiting the activity of osteoclasts. Therefore, the strontium calcium silicate-containing biological ceramic has wide application prospects in the field of treatment on bone defect repair accompanied with osteoporosis.

Description

technical field [0001] The invention relates to strontium-containing calcium silicate bioceramics, a preparation method thereof, and an application as a material for repairing osteoporotic bone defects, belonging to the field of biomaterials. Background technique [0002] Due to the rapid arrival of population aging process, my country has become the country with the most osteoporosis patients in the world. According to incomplete statistics, the total number of patients has reached 7% of the total population. And the incidence rate of concurrent fracture due to osteoporosis has exceeded 9% every year, thus it has become one of the main causes of bone disease and disability in middle-aged and elderly people. In particular, osteoporosis leads to hip fractures, and the mortality rate within one year is as high as 20%, and about 25% of those who survive for more than one year lose their basic mobility. However, due to the fragility and extremely low bone mass caused by osteop...

Claims

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Application Information

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IPC IPC(8): A61L27/10A61L27/56A61L27/50A61L27/54C04B35/16C04B35/622C04B38/06
Inventor 常江林开利金晓刚
Owner SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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