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Method for preparing high-aqueous-dispersion astaxanthin ester microspheres

A technology of astaxanthin ester and microspheres, which is applied in the field of preparation of highly water-dispersible astaxanthin ester microspheres, can solve the problems of easy oxidation and degradation, poor water solubility of astaxanthin ester, etc., achieve high water dispersibility, and facilitate industrialization Promote and improve the effect of stability

Active Publication Date: 2015-04-01
OCEAN UNIV OF CHINA
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The object of the present invention is to provide a preparation method of astaxanthin ester microspheres, by mixing astaxanthin ester, carrier oil, emulsifier, co-emulsifier and water phase under specific process conditions, astaxanthin is prepared Ester self-microemulsion, and then mix the prepared astaxanthin ester self-microemulsion with the polymer compound carrier solution, and prepare high water-dispersible astaxanthin ester microspheres by ion gelation method, and the prepared high water Dispersed astaxanthin ester microspheres are integrated from the advantages of microemulsions and solid preparations, thereby overcoming the problems of poor water solubility and easy oxidative degradation of astaxanthin esters, thus making up for the shortcomings of the existing technology

Method used

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  • Method for preparing high-aqueous-dispersion astaxanthin ester microspheres
  • Method for preparing high-aqueous-dispersion astaxanthin ester microspheres
  • Method for preparing high-aqueous-dispersion astaxanthin ester microspheres

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preparation example Construction

[0023] 1) Preparation of astaxanthin ester self-microemulsion

[0024] Dissolve astaxanthin ester in the oil phase at 10°C-80°C to make an oil solution of astaxanthin ester; agent and / or co-emulsifier, after homogenization, add the water phase, after homogenization, evaporate and remove the solvent under low temperature and low pressure conditions to prepare astaxanthin ester self-microemulsion;

[0025] 2) Preparation of high water dispersion astaxanthin ester microspheres

[0026] Add water to the polymer compound carrier to prepare a polymer compound carrier solution, then add the astaxanthin ester self-microemulsion prepared in step 1) at a volume ratio of 1:0.5-10, stir and mix well, and add the mixed liquid dropwise at a concentration of 0.2 ~3.0mol / L calcium chloride solution, stand at 2℃~10℃ for 10min~150min, let it coagulate and solidify, collect gel beads, wash and dry to make high water dispersible astaxanthin ester microspheres .

Embodiment 1

[0029] (1) Preparation of astaxanthin ester self-microemulsion

[0030] Weigh 1 kg of astaxanthin ester crude extract, and dissolve it with 3L ethyl acetate at room temperature to obtain astaxanthin ester-ethyl acetate solution; Solution 12L Tween 80 / absolute ethanol (2:1) mixture, stir or homogenize to make the system uniform; then add 10L water to the system, homogenize until the system is uniform, and then concentrate to the solid solvent with a rotary evaporator Flow out to obtain astaxanthin ester self-microemulsion.

[0031] (2) Preparation of highly water-dispersible astaxanthin ester microspheres

[0032] Prepare a sodium alginate solution with a concentration of 30g / L, and stir it at a temperature of 30°C to fully dissolve it to obtain a sodium alginate solution; then the astaxanthin ester obtained in step (1) is self-microemulsion and sodium alginate Mix the solution according to the volume ratio of 1:1, stir and mix well, drop the above mixed solution into 1mol / L ...

Embodiment 2

[0035] (1) Preparation of astaxanthin ester self-microemulsion

[0036] Weigh 1 kg of astaxanthin ester crude extract, and dissolve it with 3L ethyl oleate at room temperature to obtain astaxanthin ester-ethyl oleate solution; Ethyl acetate solution 12L Tween 80 / absolute ethanol (2:1) mixture, stir or homogenize to make the system uniform; then add 5L water to the system, homogenize until the system is uniform, and then concentrate with a rotary evaporator The solvent of the final product flows out to obtain astaxanthin ester self-microemulsion.

[0037] (2) Preparation of highly water-dispersible astaxanthin ester microspheres

[0038] Prepare a sodium alginate solution with a concentration of 30g / L, and stir it at a temperature of 30°C to fully dissolve it to obtain a sodium alginate solution; then the astaxanthin ester obtained in step (1) is self-microemulsion and sodium alginate Mix the solution according to the volume ratio of 1:0.8, stir and mix evenly, drop the above...

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Abstract

The invention discloses a method for preparing high-aqueous-dispersion astaxanthin ester microspheres. The method comprises the following steps: mixing astaxanthin ester, carrier oil, an emulsifier, a co-emulsifier and an aqueous phase under particular process conditions according to a certain proportion to prepare astaxanthin ester self-microemulsion, uniformly mixing the prepared astaxanthin ester self-microemulsion with a high-molecular compound carrier solution, and preparing the high aqueous dispersion astaxanthin ester microspheres by means of an ionic gelation method. The astaxanthin ester microspheres provided by the invention is capable of greatly improving the water dispersibility of the astaxanthin ester, relieving the oxidative degradation of the astaxanthin ester, improving the stability of the astaxanthin ester and expanding the application field of the astaxanthin ester. The method is simple in preparation process, mild in conditions, low in production cost and is convenient for industrialized promotion.

Description

technical field [0001] The invention belongs to the technical field of preparation of active substance preparations, and in particular relates to a preparation method of highly water-dispersible astaxanthin ester microspheres. Background technique [0002] Astaxanthin, also known as astaxanthin and lobster shell pigment, has a chemical name of 3,3'-dihydroxy-β,β-carotene-4,4'-dione, and its molecular formula is C 40 h 52 o 4 The relative molecular mass is 596.86, widely present in marine animals and plants. Because astaxanthin has various biological functions such as anti-oxidation, anti-inflammation, coloring, light protection, and promotion of reproduction, it has attracted much attention from food, medicine, cosmetics, aquaculture and other industries at home and abroad in recent years. Studies have found that in nature, more than 90% of astaxanthin exists in the form of esterification, and esterified astaxanthin is more stable than free astaxanthin; As the degree of ...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K9/107A61K31/215A61K8/37A61K8/02A23L1/29A23L1/272A23L5/41A23L33/00
Inventor 薛长湖周庆新王静凤徐杰薛勇张婷王彦超唐庆娟
Owner OCEAN UNIV OF CHINA
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