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Water emulsifier composition containing nervonic acid as well as preparation method and application thereof

An emulsion composition and a technique for nervonic acid are applied in the field of aqueous emulsifier compositions of nervonic acid, and can solve the problems of different bioavailability, poor oral absorption and availability of nervonic acid, etc.

Active Publication Date: 2015-04-08
FUZHOU QIANZHENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The adverse effect is that the oral absorption and utilization of nervonic acid is not good, about 30%, and the existence of nervonic acid greatly affects its digestion and absorption in the human body, whether it is natural nervonic acid or synthetic Neural acid compounds are absorbed in the body by passive diffusion, and their bioavailability varies significantly with different dosage forms, formulation combinations, preparation methods or ways of existence

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0110] Embodiment 1, nervous acid emulsion and preparation method thereof

[0111] The prescription quantity is calculated by weight percentage and contains:

[0112] Ingot maple seed oil (neuric acid content ≥ 5.0%) 0.03% to 2%, preferably 0.5% (based on nervous acid content),

[0113] Sucrose fatty acid ester 0.2%~1%, preferably 0.35%,

[0114] Sucralose 0~0.05%, preferably 0.01%,

[0115] Add purified water to 100%;

[0116] Preparation: (1) Ingredients: Weigh sucralose according to the formula and add it into purified water to dissolve completely. Separately weigh sucrose fatty acid ester and ingot maple oil, add them into purified water in turn, set the volume to the required production volume, stir and mix Evenly dispersed;

[0117] (2) Emulsification: Put the liquid prepared in (1) in the emulsification tank, and continuously feed 20-30L / min nitrogen or carbon dioxide from the bottom of the emulsification tank, when the liquid temperature is 45-65°C and the stirring...

Embodiment 2

[0122] Embodiment 2, compound ingot maple seed oil neural acid emulsion and preparation method thereof

[0123] The prescription quantity is calculated by weight percentage and contains:

[0124] Ingot maple seed oil (neuric acid content ≥ 5.0%) 0.03% to 2%, preferably 1% (based on nervous acid content),

[0125] DHA algae oil (DHA content ≥ 40%) 0.03% to 2%, preferably 1% (based on DHA content),

[0126] Sucrose fatty acid ester 0.2%~1%, preferably 0.5%,

[0127] Add purified water to 100%;

[0128] Preparation: (1) Ingredients: Weigh sucrose fatty acid ester, ingot maple seed oil, and DHA algae oil according to the formula, add them into purified water in sequence, set the volume to the required production volume, stir, mix and disperse evenly;

[0129] (2) Emulsification: Put the liquid prepared in (1) in the emulsification tank, and continuously feed 20-30L / min nitrogen or carbon dioxide from the bottom of the emulsification tank, when the liquid temperature is 45-65°C an...

Embodiment 3

[0134] Embodiment 3, nervonic acid linolenic acid emulsion and preparation method thereof

[0135] The prescription quantity is calculated by weight percentage and contains:

[0136] Nervous acid 0.03%~2%, preferably 1.5%,

[0137] Peony seed oil (linolenic acid content ≥ 38%) 0.5% to 10%, preferably 3% (based on linolenic acid content),

[0138] Glyceryl distearate 0.1%~3.5%, preferably 2.0%,

[0139] Add purified water to 100%;

[0140] Preparation: (1) Ingredients: Weigh according to the formula, dissolve nervous acid in peony seed oil, then add glyceryl distearate and peony seed oil with nervous acid dissolved in purified water in sequence, and dilute to the desired production volume. amount, stir to mix and disperse evenly;

[0141] (2) Emulsification: Put the liquid prepared in (1) in the emulsification tank, and continuously feed 20-30L / min nitrogen or carbon dioxide from the bottom of the emulsification tank, when the liquid temperature is 45-65°C and the stirring ...

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Abstract

The invention provides an emulsion composition containing nervonic acid, an emulsifier and water, wherein content of water in the emulsion composition is more than 70% in weight ratio, particle size of a fat globule in the emulsion composition is less than 5Mum, weight ratio of the emulsifier to the nervonic acid is 1:(0.1-6), and the emulsifier comprises one or more than one of the following substances: sucrose fatty acid ester, glyceryl monostearate, glycerol distearate, polyglycerol fatty acid ester, sodium stearoyl lactate and sorbitan fatty acid ester. The invention also provides a preparation method of the emulsion composition and application of the emulsion composition in a health product which is orally taken for supplementing the nervonic acid or unsaturated fatty acid and is used for preventing and treating diseases such as cranial nerve degenerative change, disordered brain function and the like.

Description

technical field [0001] The invention relates to a health product composition and a preparation method thereof, in particular to an aqueous emulsifier composition of nervonic acid, a preparation method and application thereof. The health product composition of the present invention includes but not limited to medicine, medical food, health food or functional food, common food and so on. Background technique [0002] Neural acid, cis-15-tetradecenoic acid, is a long-chain monounsaturated fatty acid, which is an important component of biological membranes in nervous tissue, a symbolic component of cerebroside medulla, cranial nerve fibers and nerve The core natural component of cells is also an essential nutrient for the growth, regeneration and function maintenance of nerve cells, especially brain cells, optic nerve cells, and peripheral nerves. It mainly exists in human brain tissue in the form of glycosphingolipids and sphingomyelin. It plays an important role in the biosyn...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K31/201A61K31/202A61K31/685A61K8/55A61K8/63A61K8/92A61K8/36A61K8/06A61P3/02A23L1/29A61Q19/00A61K47/26A61K47/14A61K47/34A61K31/20A23L33/00
Inventor 张耿元王保红白东跃唐湘成俞世宏
Owner FUZHOU QIANZHENG PHARMA
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