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Zinc gluconate composition freeze-dried tablets and preparation method thereof

A technology of zinc gluconate and composition, applied in the field of zinc gluconate composition freeze-dried tablet and preparation thereof, to achieve the effects of improving adhesion, high bioavailability and improving bioavailability

Inactive Publication Date: 2015-04-08
HAINAN WEI KANG PHARMA QIANSHAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Starch is the basic excipient of oral solid preparations. It is formed by the polymerization of glucose molecules. It is often used as a binder, diluent and disintegrating agent in tablets. It is cheap and easy to obtain, and is safe for the human body. However, starch is used alone as an excipient There is no report on the production of zinc gluconate freeze-dried tablets by freeze-drying process

Method used

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  • Zinc gluconate composition freeze-dried tablets and preparation method thereof
  • Zinc gluconate composition freeze-dried tablets and preparation method thereof
  • Zinc gluconate composition freeze-dried tablets and preparation method thereof

Examples

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Effect test

Embodiment 1

[0027]

[0028]

[0029] A. Weigh 100g of cornstarch, add 900ml of purified water and stir, use a pH regulator to control the pH of the solution at 5-7.5, then heat to 72°C and keep for 120 minutes to make 9% (W / V) cornstarch solution.

[0030] B. Measure 45ml of purified water, boil, add 85g of sucrose, stir, after dissolving, continue heating to 100°C, filter with refined cotton, wash the filter with an appropriate amount of hot distilled water, combine the lotion and filtrate, let cool, add Add appropriate amount of distilled water to make the whole volume into 100mL, stir well to obtain B solution.

[0031] C. Mix the solution obtained in step A with the solution obtained in step B, fully stir for 30 minutes, and then lower the solution to normal temperature to obtain a corn-sucrose solution.

[0032] D. Weigh 35g of zinc gluconate, add it into 1L corn-sucrose solution, and stir for 30 minutes.

[0033] E. After measuring the zinc gluconate content of the medicinal...

Embodiment 2

[0036]

[0037] A. Weigh 130g of cornstarch, add 900ml of purified water and stir, use a pH regulator to control the pH of the solution at 5-7.5, then heat to 72°C and keep for 120 minutes to make 13% (W / V) cornstarch solution.

[0038] B. Measure 45ml of purified water, boil, add 85g of sucrose, stir, after dissolving, continue heating to 100°C, filter with refined cotton, wash the filter with an appropriate amount of hot distilled water, combine the lotion and filtrate, let cool, add Add appropriate amount of distilled water to make the whole volume into 100mL, stir well to obtain B solution.

[0039] C. Mix the solution obtained in step A with the solution obtained in step B, fully stir for 30 minutes, and then lower the solution to normal temperature to obtain a corn-sucrose solution.

[0040] D, take by weighing 35 grams of zinc gluconate (calculated by 1000 tablets), add 1L corn-sucrose solution, and stir for 30 minutes.

[0041] E. After measuring the zinc gluconat...

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Abstract

The invention provides zinc gluconate composition freeze-dried tablets and a preparation method thereof, relating to the technical field of medicine and medicine production. The zinc gluconate composition freeze-dried tablets comprise zinc gluconate, starch and sucrose; the starch and sucrose are used as accessories, common corn starch is processed by a heating process, the bonding and disintegration effects of the starch in the tablets can be improved, the formability of the tablets is increased, and only two accessories, namely starch and sucrose, are needed in the zinc gluconate composition freeze-dried tablets. A freeze-drying process of two-time reduction and two-time increase is adopted for the zinc gluconate composition freeze-dried tablets, the formability of the tablets is better through two-time reduction and two-time increase of temperature, and the dissolubility of the tablets is improved so as to improve the bioavailability of the tablets; the tablets overcome the shortcomings of common zinc gluconate tablets, and the types and amount of accessories in the zinc gluconate tablets are reduced; and moreover, the dissolubility and bioavailability of the tablets are high, and the curative effect and safety of clinical medication are guaranteed.

Description

technical field [0001] The invention relates to the technical field of medicine and medicine production, in particular to a zinc gluconate composition freeze-dried tablet and a preparation method thereof. Background technique [0002] Zinc gluconate is a zinc supplement drug, mainly used for infants and the elderly, pregnant women who suffer from growth retardation, malnutrition, anorexia, recurrent oral ulcers, skin acne and other diseases caused by zinc deficiency. [0003] structural formula [0004] Molecular weight: 455.68 [0005] Ordinary zinc gluconate tablets contain many types and quantities of excipients. Generally, fillers, lubricants, disintegrants, binders, flavoring agents, etc. are used. Zinc tablet quality standard, the dissolution rate of zinc gluconate tablet reaches more than 75% in 30 minutes is qualified, and more and more studies have shown the toxic and side effects of the excipient itself, the incompatibility of the excipient and the main drug, i...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/315A61K47/36A61K47/26A61P3/02
Inventor 程学文石金友汪金灿郝结兵吴函峰
Owner HAINAN WEI KANG PHARMA QIANSHAN