A kind of preparation method of absorbable suture

A suture and casing technology, applied in the field of suture, can solve the problems of suture quality influence, mechanical strength decline, material hydrolysis deterioration, etc., to achieve the effect of accelerating wound healing, stabilizing absorption period and avoiding infection

Active Publication Date: 2017-09-19
SHANDONG BODA MEDICAL PROD CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, chemical line raw materials are less and are controlled by foreign companies, so it is extremely difficult to obtain, and the cost increases a lot
In addition, if the moisture content of the chemical thread is too high, the material will be hydrolyzed and deteriorated, the mechanical strength will be reduced, and the quality of the suture will be seriously affected.
Therefore, the raw materials of the chemical line rely heavily on imports, the procurement cycle is long, and the storage requirements are high

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] The present invention is used to prepare a kind of absorbable suture, and its preparation method comprises the following steps:

[0022] (1) Isolate protein chorion: select fresh goat casing, wash the inner wall of the casing, and scrape the intestinal chorion, mucous membrane, serosa, etc. in the casing to make it fall off;

[0023] (2) Purification of collagen fibers: After cleaning the above-mentioned sheep casings, put them in 0.9% sodium chloride solution and soak for 30 minutes. After taking them out, put them directly in 30% sodium chloride solution and soak them for 10 minutes, and then separate and remove them. The fat in the collagen fibers, resulting in relatively pure collagen fibers;

[0024] (3) Degreasing and degreasing: the above-mentioned purified collagen fibers are added to a 0.5% sodium hydroxide solution at a temperature of 40 degrees Celsius and soaked for 15 minutes. The solution is also added with 1% by weight of dodecyl sulfate. Sodium, so that...

Embodiment 2

[0032] The present invention is used to prepare a kind of absorbable suture, and its preparation method comprises the following steps:

[0033] (1) Isolate protein chorion: select fresh goat casing, wash the inner wall of the casing, and scrape the intestinal chorion, mucous membrane, serosa, etc. in the casing to make it fall off;

[0034] (2) Purification of collagen fibers: After cleaning the above-mentioned sheep casings, put them in 0.9% sodium chloride solution and soak for 30 minutes. After taking them out, put them directly in 30% sodium chloride solution and soak them for 10 minutes, and then separate and remove them. The fat in the collagen fibers, resulting in relatively pure collagen fibers;

[0035] (3) Degreasing and degreasing: The above-mentioned purified collagen fibers are added to a 2% sodium hydroxide solution at a temperature of 60 degrees Celsius and soaked for 10 minutes. The solution is also added with 0.5% by weight of dodecylbenzene. Sodium sulfonate...

Embodiment 3

[0043] The present invention is used to prepare a kind of absorbable suture, and its preparation method comprises the following steps:

[0044] (1) Isolate protein chorion: select fresh goat casing, wash the inner wall of the casing, and scrape the intestinal chorion, mucous membrane, serosa, etc. in the casing to make it fall off;

[0045] (2) Purification of collagen fibers: After cleaning the above-mentioned sheep casings, put them in 0.9% sodium chloride solution and soak for 30 minutes. After taking them out, put them directly in 30% sodium chloride solution and soak them for 10 minutes, and then separate and remove them. The fat in the collagen fibers, resulting in relatively pure collagen fibers;

[0046] (3) Degreasing and degreasing: the above-mentioned purified collagen fibers are added to a 1.5% sodium hydroxide solution with a temperature of 55 degrees Celsius and soaked for 12 minutes. The solution is also added with 0.8% sodium stearate by weight. So that the oi...

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PUM

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Abstract

The invention relates to a suture, in particular to a preparation method of an absorbable suture. The preparation method of the absorbable suture of the present invention comprises the following steps: (1) separating protein chorion; (2) purifying collagen fibers; (3) degreasing and degreasing; (4) virus inactivation; (5) chrome tanning; 6) Cross-linking and dehydration; (7) Polishing; (8) Chitosan atomization; (9) Packaging. The retractable suture thread prepared by the method of the invention has the characteristics of high tensile strength, firm knotting, good biocompatibility, thread body can be absorbed by the body, and small toxic and side effects. The thread body of the present invention is completely absorbed, has no absorption reaction, does not need to be removed, has good tissue compatibility, and has no adverse reaction regardless of the length of time in the human body; the surface is smooth, is not easy to be contaminated with bacteria, and can avoid infection.

Description

(1) Technical field [0001] The present invention relates to a suture, in particular to a preparation method of an absorbable suture. (2) Background technology [0002] Medical sutures belong to the category of medical devices, and sutures are divided into two categories in the same industry: one is non-absorbable sutures: silk, polypropylene, nylon, etc.; the other is absorbable sutures: respectively For chemical lines and biological lines. At present, PGA chemically absorbable sutures are widely used in my country. However, the raw materials of chemical lines are few and controlled by foreign companies, so it is extremely difficult to obtain and the cost increases a lot. In addition, the high moisture content of the chemical thread will lead to the degradation of the material by hydrolysis, the decrease of the mechanical strength, and the quality of the suture thread will be seriously affected. Therefore, the raw materials of the chemical line rely heavily on imports, th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L17/08
Inventor 张玉福高宏宇张硕黄绍青
Owner SHANDONG BODA MEDICAL PROD CO LTD
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