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Biomedical degradable metal capable of treating rheumatoid arthritis, and applications thereof

A biomedical and arthritis technology, applied in medical science, prosthesis, coating, etc., can solve the problems of biocompatibility of rare earth elements, excessive corrosion and degradation, neurotoxicity and other problems, and achieve the treatment of rheumatoid joints Inflammation, satisfactory corrosion resistance, and the effect of promoting osteoblast bone formation

Active Publication Date: 2015-04-15
SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Magnesium and magnesium alloys have been used as bone implant materials for more than 70 years. Although it has been clinically proven that magnesium and magnesium alloys have good biocompatibility, they corrode and degrade too quickly in the human body and produce hydrogen gas, which has become one of their clinical applications. big obstacle
At the same time, magnesium alloys often contain impurities, such as A1 elements and rare earth elements, etc. A1 elements are not essential trace elements for the human body, and are neurotoxic. The biocompatibility of rare earth elements is controversial, and the accumulation shows toxic effects

Method used

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  • Biomedical degradable metal capable of treating rheumatoid arthritis, and applications thereof
  • Biomedical degradable metal capable of treating rheumatoid arthritis, and applications thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0033] This embodiment provides a Mg-Zn-Mn-Se-Cu alloy, the content of Zn is 3.5wt%, the content of Mn is 0.5wt%, the content of Se is 0.4wt%, the content of Cu is 0.2wt%, and the balance of Mg. Manufactured through high-purity raw materials and high-cleanness smelting technology. After heat treatment and deformation processing, it can be made into the desired shape and shape, and further made into various orthopedic implants for clinical treatment.

[0034] After testing, the tensile strength of the Mg-Zn-Mn-Se-Cu alloy provided in this example is 200 MPa, and the elongation is 12%. Biological evaluation was carried out according to the experimental method described in GB / T16886. The experimental results show that the Mg-Zn-Mn-Se-Cu alloy provided in this example has no obvious cytotoxicity and coagulation on chondrocytes, osteoblasts and bone marrow mesenchymal stem cells, and has no obvious sensitization, stimulation and genotoxicity .

[0035] The Mg-Zn-Mn-Se-Cu alloy p...

Embodiment 2

[0037]This embodiment provides a Mg-Zn-Mn-Sr-Cu alloy, the content of Zn is 2.5wt%, the content of Mn is 0.5wt%, the content of Sr is 2wt%, the content of Cu is 0.9wt%, and the balance of Mg. Manufactured through high-purity raw materials and high-cleanness smelting technology. After heat treatment and deformation processing, it can be made into the desired shape and shape, and further made into various orthopedic implants for clinical treatment.

[0038] After testing, the tensile strength of the Mg-Zn-Mn-Sr-Cu alloy provided in this embodiment is 220Mpa, and the elongation is 11%. Biological evaluation was carried out according to the experimental method described in GB / T16886. The experimental results show that the Mg-Zn-Mn-Sr-Cu alloy provided in this example has no obvious cytotoxicity and coagulation on chondrocytes, osteoblasts and bone marrow mesenchymal stem cells, and has no obvious sensitization, stimulation and genotoxicity .

[0039] The Mg-Zn-Mn-Sr-Cu alloy pr...

Embodiment 3

[0041] This embodiment provides a Mg-Mn-Se-Sr-Cu alloy, the content of Mn is 0.6wt%, the content of Se is 1.4wt%, the content of Sr is 1.8wt%, the content of Cu is 0.5wt%, and the balance of Mg. Manufactured through high-purity raw materials and high-cleanness smelting technology. After heat treatment and deformation processing, it can be made into the desired shape and shape, and further made into various orthopedic implants for clinical treatment.

[0042] After testing, the tensile strength of the Mg-Mn-Se-Sr-Cu alloy provided in the embodiment is 210Mpa, and the elongation is 11%. Biological evaluation was carried out according to the experimental method described in GB / T16886. The experimental results show that the Mg-Mn-Se-Sr-Cu alloy provided in this example has no obvious cytotoxicity and coagulation to chondrocytes, osteoblasts and bone marrow mesenchymal stem cells, and has no obvious sensitization, stimulation and genotoxicity .

[0043] The Mg-Mn-Se-Sr-Cu alloy ...

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Abstract

The present invention provides a biomedical degradable metal capable of treating rheumatoid arthritis. The biomedical degradable metal is a magnesium alloy and contains magnesium and a second component, wherein the second component is one or a plurality of materials selected from zinc, manganese, selenium, strontium and calcium, the content of the second component is less than or equal to 10 wt%, and the balance is magnesium. According to the present invention, the magnesium alloy has characteristics of good biocompatibility, satisfactory corrosion resistance and no significant cytotoxicity, can be degraded and absorbed in biological body fluids or bloods, has application values in medical fields of endovascular interventional therapy, endosseous implant and the like, and especially releases beneficial elements through in vivo degradation so as to inhibit activation of macrophages and other inflammatory cells, promote osteoblast bone formation, and inhibit osteoclast bone resorption, such that the biomedical degradable metal has the potential effects of rheumatoid arthritis treating and the like.

Description

technical field [0001] The invention relates to an alloy material, in particular to a biodegradable and absorbable magnesium alloy with good biocompatibility which can be used as a medical implant material and its application. Background technique [0002] Biodegradable absorbent materials have great potential application prospects. At present, there are two main types of biodegradable absorbing materials in vivo, namely polymer materials and ceramic materials, but both have disadvantages such as low mechanical properties or poor plasticity and toughness. However, metal materials have good comprehensive properties. Therefore, metal-based biodegradable absorbing materials have important medical application value. [0003] Magnesium ion is the second most abundant cation in human cells. It is an indispensable and important nutritional element for the human body. It participates in a series of metabolic processes in the human body, including promoting the formation of osteobla...

Claims

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Application Information

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IPC IPC(8): A61L27/04A61L27/34A61L27/32A61L27/58
Inventor 曲新华戴尅戎翟赞京秦安
Owner SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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